1887

Abstract

Goats are susceptible to experimental challenge with bovine spongiform encephalopathy (BSE). This study set out to investigate whether the transmission of BSE could occur in goats following the transfer of embryos from experimentally infected donor females into uninfected recipient females. The results showed no evidence of transmissible spongiform encephalopathy disease in any of the offspring which developed from embryos from infected donors, nor indeed in any of the recipient females used as surrogate dams. In addition, there was no indication of experimental BSE spreading as either a venereal infection to males used in mating or by maternal transmission to offspring born naturally to experimentally infected donors, although numbers were small.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-80-2-517
1999-02-01
2024-04-20
Loading full text...

Full text loading...

/deliver/fulltext/jgv/80/2/0800517a.html?itemId=/content/journal/jgv/10.1099/0022-1317-80-2-517&mimeType=html&fmt=ahah

References

  1. Brotherston J. G. , Renwick C. C. , Stamp J. T. , Zlotnik I. , Pattison I. H. . 1968; Spread of scrapie by contact to goats and sheep. Journal of Comparative Pathology 78:9–17
    [Google Scholar]
  2. Dickinson A. G. , Stamp J. T. , Renwick C. C. . 1974; Maternal and lateral transmission of scrapie in sheep. Journal of Comparative Pathology 84:19–25
    [Google Scholar]
  3. Foote W. C. , Clark W. , Maciulis A. , Call J. W. , Hourrigan J. , Evans R. C. , Marshall M. R. , de Camp M. . 1993; Prevention of scrapie transmission in sheep, using embryo transfer. American Journal of Veterinary Research 54:1863–1868
    [Google Scholar]
  4. Foster J. D. , Dickinson A. G. . 1988; The unusual properties of CH1641, a sheep-passaged isolate of scrapie. Veterinary Record 123:5–8
    [Google Scholar]
  5. Foster J. D. , McKelvey W. A. C. , Mylne M. J. A. , Williams A. , Hunter N. , Hope J. , Fraser H. . 1992; Studies on maternal transmission of scrapie in sheep by embryo transfer. Veterinary Record 130:341–343
    [Google Scholar]
  6. Foster J. D. , Hope J. , Fraser H. . 1993; Transmission of bovine spongiform encephalopathy in sheep and goats. Veterinary Record 133:339–341
    [Google Scholar]
  7. Foster J. D. , Hunter N. , Williams A. , Mylne M. J. A. , McKelvey W. A. C. , Hope J. , Fraser H. , Bostock C. . 1996; Observations on the transmission of scrapie in experiments using embryo transfer. Veterinary Record 138:559–562
    [Google Scholar]
  8. Fraser H. . 1976; The pathology of natural and experimental scrapie. In Slow Virus Diseases of Animals and Man pp 267–305 Edited by Kimberlin R. H. . Amsterdam: Elsevier;
    [Google Scholar]
  9. Fraser H. , Foster J. . 1994 Transmission to mice, sheep and goats and bioassay of bovine tissues. Proceedings of a consultation on BSE with the Scientific Veterinary Committee of the Commission of the European Communities (CEE) (Brussels, 1993) pp 145–159 Edited by Bradley R. , Savey M. , Marchant B. . Dordrecht: Kluwer Academic;
    [Google Scholar]
  10. Goldmann W. , Martin T. , Foster J. , Hughes S. , Smith G. , Hughes K. , Dawson M. , Hunter N. . 1996; Novel polymorphisms in the caprine PrP gene: a codon 142 mutation associated with scrapie incubation period. Journal of General Virology 77:2885–2891
    [Google Scholar]
  11. Goldmann W. , Chong A. , Foster J. , Hope J. , Hunter N. . 1998; The shortest known prion protein gene allele occurs in goats, has only three octapeptide repeats and is non-pathogenic. Journal of General Virology 79:3173–3176
    [Google Scholar]
  12. Greig J. R. . 1950; Scrapie in sheep. Journal of Comparative Pathology 60:263–266
    [Google Scholar]
  13. Hadlow W. J. , Eklund C. M. , Kennedy R. C. , Jackson T. A. , Whitford H.W. , Boyle C.C. . 1974; Course of experimental scrapie virus infection in the goat. Journal of Infectious Diseases 129:559–567
    [Google Scholar]
  14. Hadlow W. J. , Prusiner S. B. , Kennedy R. C. , Race R. E. . 1980; Brain tissue from persons dying of Creutzfeldt–Jakob disease causes scrapie-like encephalopathy in goats. Annals of Neurology 8:628–631
    [Google Scholar]
  15. Hope J. , Morton L. J. D. , Farquhar C. F. , Multhaup G. , Beyreuther K. , Kimberlin R. H. . 1986; The major protein of scrapie-associated fibrils (SAF) has the same size, charge distribution and N-terminal protein sequence as predicted for the normal brain protein (PrP). EMBO Journal 5:2591–2597
    [Google Scholar]
  16. Hourrigan J. L. , Klingsporn A. L. , Clark W. W. , de Camp M. . 1979; Epidemiology of scrapie in the United States. In Slow Transmissible Diseases of the Nervous System vol 1 pp 331–355 Edited by Prusiner S. B. , Hadlow W. J. . New York: Academic Press;
    [Google Scholar]
  17. Outram G. W. , Dickinson A. G. , Fraser H. . 1973; Developmental maturation of susceptibility to scrapie in mice. Nature 241:536–537
    [Google Scholar]
  18. Pattison I. H. , Millson G. C. . 1960; Further observations on the experimental production of scrapie in goats and sheep. Journal of Comparative Pathology 70:182–193
    [Google Scholar]
  19. Pattison I. H. , Millson G. C. . 1961; Experimental transmission of scrapie to goats and sheep by the oral route. Journal of Comparative Pathology 71:171–176
    [Google Scholar]
  20. Wilesmith J. W. , Wells G. A. H. , Ryan J. B. M. , Gavier-Widen D. , Simmons M. M. . 1997; A cohort study to examine maternally-associated risk factors for bovine spongiform encephalopathy. Veterinary Record 141:239–243
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-80-2-517
Loading
/content/journal/jgv/10.1099/0022-1317-80-2-517
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error