1887

Abstract

Adult thymectomized C57 BL/6J mice were depleted of T cell subsets by MAb treatment either prior to, or after, respiratory challenge with murine gammaherpesvirus-68. Protection against acute infection was maintained when either the CD4+ or the CD8+ T cell population was greatly diminished, whereas the concurrent removal of both T cell subsets proved invariably fatal. The same depletions had little effect on mice with established infection. The results indicate firstly that both CD4+ and CD8+ T cells play a significant part in dealing with the acute infection, and secondly that virus-specific antibody contributes to controlling persistent infection with this gammaherpesvirus.

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/content/journal/jgv/10.1099/0022-1317-80-2-477
1999-02-01
2022-08-10
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References

  1. Cardin R. C., Brooks J. W., Sarawar S. R., Doherty P. C. 1996; Progressive loss of CD8+ T cell-mediated control of a γ-herpesvirus in the absence of CD4+ T cells. Journal of Experimental Medicine 184:863–871
    [Google Scholar]
  2. Efstathiou S., Ho Y. M., Hall S., Styles C. J., Scott S. D., Gompels U.A. 1990; Murine herpesvirus 68 is genetically related to the gammaherpesviruses Epstein–Barr virus and herpesvirus saimiri. Journal of General Virology 71:1365–1372
    [Google Scholar]
  3. Ehtisham S., Sunil-Chandra N. P., Nash A. A. 1993; Pathogenesis of murine gammaherpesvirus infection in mice deficient in CD4 and CD8 T cells. Journal of Virology 67:5147–5252
    [Google Scholar]
  4. Grusby M. J., Johnson R. S., Papaioannou V. E., Glimcher L. E. 1991; Depletion of CD4+ T cells in major histocompatibility complex class II-deficient mice. Science 253:1417–1420
    [Google Scholar]
  5. Jonjic S., Pavic I., Lucin P., Rukavina D., Koszinowski U. H. 1990; Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes. Journal of Virology 64:5457–5464
    [Google Scholar]
  6. Jonjic S., Pavic I., Polic B., Crnkovic I., Lucin P., Koszinowski U. H. 1994; Antibodies are not essential for the resolution of primary cytomegalovirus infection but limit dissemination of recurrent virus. Journal of Experimental Medicine 179:1713–1717
    [Google Scholar]
  7. Kagi D., Ledermann B., Burki K., Seiler P., Odermatt B., Olsen K. J., Podack E. R., Zinkernagel R. M., Hengartner H. 1994; Cytotoxicity mediated by T cells and natural killer cells is greatly impaired in perforin-deficient mice. Nature 369:31–37
    [Google Scholar]
  8. Raulet D. H. 1994; MHC class I-deficient mice. Advances in Immunology 55:381–421
    [Google Scholar]
  9. Rickinson A. B., Kieff E. 1996; Epstein-Barr Virus. In Fields Virology 3rd edn, pp 2397–2446 Edited by Fields B. N., Knipe D. M., Howley P. M. Philadelphia: Lippincott–Raven;
    [Google Scholar]
  10. Stevenson P. G., Doherty P. C. 1998; Kinetic analysis of the host immune response to a murine gammaherpesvirus. Journal of Virology 72:943–949
    [Google Scholar]
  11. Stewart J. P., Usherwood E. J., Ross A. J., Allen H., Nash A. A. 1998; Lung epithelial cells are a major site of murine gammaherpesvirus persistence. Journal of Experimental Medicine 187:1941–1995
    [Google Scholar]
  12. Sunil-Chandra N. P., Efstathiou S., Nash A. A. 1992; Murine gammaherpesvirus 68 establishes a latent infection in mouse B lymphocytes in vivo . Journal of Virology 73:3275–3279
    [Google Scholar]
  13. Sunil-Chandra N. P., Arno J., Fazakerley J., Nash A. A. 1994; Lymphoproliferative disease in mice infected with murine gammaherpesvirus 68. Journal of Pathology 8:18–826
    [Google Scholar]
  14. Usherwood E. J., Ross A. J., Allen D. J., Nash A. A. 1996; Murine gammaherpesvirus-induced splenomegaly: a critical role for CD4 T cells. Journal of General Virology 77:627–630
    [Google Scholar]
  15. Usherwood E. J., Brooks J. W., Sarawar S. R., Cardin R. D., Young W. D., Allen D. J., Doherty P. C., Nash A. A. 1997; Immunological control of murine gammaherpesvirus infection is independent of perforin. Journal of General Virology 78:2025–2030
    [Google Scholar]
  16. Virgin H. W. IV, Latrielle P., Wamsley P., Hallsworth K., Weck K. E., Dal Canto A. J., Speck S. J. 1997; Complete sequence and genomic analysis of murine gammaherpesvirus 68. Journal of Virology 71:5894–5904
    [Google Scholar]
  17. Weck K. E., Barkon M. L., Yoo L. I., Speck S. H., Virgin H. W. 1996; Mature B cells are required for acute splenic infection but not for establishment of latency by murine gammaherpesvirus 68. Journal of Virology 70:6775–6780
    [Google Scholar]
  18. Weck K. E., Dal Canto A. J., Gould J. D., O’Guin A. K., Roth K. A., Saffitz J. E., Speck S. H., Virgin H. W. 1997; 68 causes severe large-vessel arteritis in mice lacking interferon-y responsiveness: a new model for virus-induced vascular disease. Nature Medicine 3:1346–1353
    [Google Scholar]
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