@article{mbs:/content/journal/jgv/10.1099/0022-1317-80-2-441, author = "Buck, M. and Cross, S. and Krauer, K. and Kienzle, N. and Sculley, T. B.", title = "A-type and B-type Epstein-Barr virus differ in their ability to spontaneously enter the lytic cycle", journal= "Journal of General Virology", year = "1999", volume = "80", number = "2", pages = "441-445", doi = "https://doi.org/10.1099/0022-1317-80-2-441", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-80-2-441", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "In this study replication of A-type and B-type Epstein-Barr virus (EBV) strains has been assessed. A-type and B-type type lymphoblastoid cell lines (LCLs) were established by infecting B lymphocytes, isolated from five EBV-seropositive donors, with different A-type and B-type virus isolates. The presence of viral capsid antigens (VCA) in these LCLs was determined by immunofluoresence assay and by immunoblotting. All of the B-type EBV strains were capable of spontaneously generating virus regardless of the origin of the donor cells. In contrast the A-type strains, other than strain IARC-BL36, did not readily produce VCA in any of the different donor lymphocytes used. This study demonstrates another biological difference between the two virus types: their ability to spontaneously enter the lytic cycle.", }