RT Journal Article SR Electronic(1) A1 Kjellberg, Lennart A1 Wang, Zhaohui A1 Wiklund, Fredrik A1 Edlund, Karin A1 Ångström, Tord A1 Lenner, Per A1 Sjöberg, Inga A1 Hallmans, Göran A1 Wallin, Keng-Ling A1 Sapp, Martin A1 Schiller, John A1 Wadell, Göran A1 Mählck, Carl-Gustav A1 Dillner, JoakimYR 1999 T1 Sexual behaviour and papillomavirus exposure in cervical intraepithelial neoplasia: a population-based case-control study JF Journal of General Virology, VO 80 IS 2 SP 391 OP 398 DO https://doi.org/10.1099/0022-1317-80-2-391 PB Microbiology Society, SN 1465-2099, AB Sexual history is an established risk determinant for cervical neoplasia. It is not clear if human papillomavirus (HPV) exposure entirely explains the sexual behaviour-related risk or if other sexually transmitted agents may act as cofactors for HPV in carcinogenesis. The aim of this study was to elucidate whether HPV exposure or HPV persistence explains the sexual history-related risk of high-grade cervical intraepithelial neoplasia (CIN) using a population-based case-control study of most of the 254 women referred to colposcopy in the Vasterbotten county in Sweden because of an abnormal cervical smear during October 1993 to December 1995 and 320 age-matched women from the general population. The women were interviewed for sexual history and tested for presence of serum antibodies to HPV-16, -18 and -33 as well as for presence of HPV DNA in cervical brush samples. HPV-16, -18 and -33 seropositivity was specific for the corresponding type of HPV DNA, dependent on the lifetime sexual history and associated with a two- to threefold increased risk of CIN 3. There was no sexual history-related risk of CIN among HPV-seropositive women and adjustment for HPV DNA presence explained the sexual history-related risk of CIN. In conclusion, HPV exposure appeared to explain the sexual history-related risk of high-grade CIN., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-80-2-391