@article{mbs:/content/journal/jgv/10.1099/0022-1317-80-12-3159, author = "Kim, Yoon Ki and Jang, Sung Key", title = "La protein is required for efficient translation driven by encephalomyocarditis virus internal ribosomal entry site", journal= "Journal of General Virology", year = "1999", volume = "80", number = "12", pages = "3159-3166", doi = "https://doi.org/10.1099/0022-1317-80-12-3159", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-80-12-3159", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Translation of internal ribosomal entry site (IRES)-dependent mRNAs is mediated by RNA-binding proteins as well as canonical translation factors. In order to elucidate the roles of RNA-binding proteins in IRES-dependent translation, the role of polypyrimidine tract-binding protein (PTB) and La protein in encephalomyocarditis virus (EMCV) IRES-dependent translation was investigated. PTB was required for efficient EMCV IRES-driven translation but, intriguingly, an excess of PTB suppressed it. Such a translational suppression by surplus PTB was relieved by addition of La protein. A possible role for La protein in IRES-dependent translation is discussed.", }