1887

Abstract

We have previously reported that tick-borne encephalitis (TBE) is endemic in a specific area of Hokkaido, Japan. In Oshima, the southern part of Hokkaido, TBE virus was isolated from sentinel dogs, ticks and rodents in 1995 and 1996. To identify when these TBE viruses emerged in Hokkaido, the times of divergence of TBE virus strains isolated in Oshima and far-eastern Russia were estimated. TBE virus was isolated in Khabarovsk in 1998 and the nucleotide sequences of viral envelope protein genes of isolates from Oshima and Khabarovsk were compared. From the synonymous substitution rate of these virus strains, the lineage divergence time of these TBE virus strains was predicted phylogenetically to be about 260–430 years ago. Furthermore, the virulence of TBE virus isolates from Oshima and Khabarovsk were compared in a mouse model. The results showed that the isolates possessed very similar virulence in mice. This report provides evidence that the Oshima strains of TBE virus in Hokkaido emerged from far-eastern Russia a few hundred years ago and this explains why these strains possess virulence similar to the TBE viruses isolated in Russia.

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1999-12-01
2019-12-08
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References

  1. Calisher, C. H., Karabatsos, N., Dalrymple, J. M., Shope, R. E., Porterfield, J. S., Westaway, E. G. & Brandt, W. E. ( 1989; ). Antigenic relationships between flaviviruses as determined by cross-neutralization tests with polyclonal antisera. Journal of General Virology 70, 37-43.[CrossRef]
    [Google Scholar]
  2. Chiba, N., Iwasaki, T., Mizutani, T., Kariwa, H., Kurata, T. & Takashima, I. ( 1999; ). Pathogenicity of tick-borne encephalitis virus isolated in Hokkaido, Japan in mouse model. Vaccine 17, 779-787.[CrossRef]
    [Google Scholar]
  3. De Madrid, A. T. & Porterfield, J. S. ( 1974; ). The flaviviruses (group B arboviruses): a cross-neutralization study. Journal of General Virology 23, 91-96.[CrossRef]
    [Google Scholar]
  4. Ecker, M., Allison, S. L., Meixner, T. & Heinz, F. X. ( 1999; ). Sequence analysis and genetic classification of tick-borne encephalitis viruses from Europe and Asia. Journal of General Virology 80, 179-185.
    [Google Scholar]
  5. Felsenstein, J. ( 1985; ). Confidence limits on phylogenies: an approach using the bootstrap. Evolution 39, 783-791.[CrossRef]
    [Google Scholar]
  6. Gojobori, T., Moriyama, E. N. & Kimura, M. ( 1990; ). Molecular clock of viral evolution, and the neutral theory. Proceedings of the National Academy of Sciences, USA 87, 10015-10018.[CrossRef]
    [Google Scholar]
  7. Gould, E. A., Zanotto, P. M. de A. & Holmes, E. C. ( 1997; ). The genetic evolution of flaviviruses. In Factors in the Emergence of Arbovirus Diseases, pp. 51-63. Edited by J. F. Saluzzo & B. Dodet. Amsterdam: Elsevier.
  8. Guirakhoo, F., Heinz, F. X. & Kunz, C. ( 1989; ). Epitope model of tick-borne encephalitis virus envelope glycoprotein E: analysis of structural properties, role of carbohydrate side chain, and conformational changes occurring at acidic pH. Virology 169, 90-99.[CrossRef]
    [Google Scholar]
  9. Holzmann, H., Heinz, F. X., Mandl, C. W., Guirakhoo, F. & Kunz, C. ( 1990; ). A single amino acid substitution in envelope protein E of tick-borne encephalitis virus leads to attenuation in the mouse model. Journal of Virology 64, 5156-5159.
    [Google Scholar]
  10. Holzmann, H., Vorobyova, M. S., Ladyzhenskaya, I. P., Ferenczi, E., Kundi, M., Kunz, C. & Heinz, F. X. ( 1992; ). Molecular epidemiology of tick-borne encephalitis virus: cross-protection between European and Far Eastern subtypes. Vaccine 10, 345-349.[CrossRef]
    [Google Scholar]
  11. Holzmann, H., Stiasny, K., Ecker, M., Kunz, C. & Heinz, F. X. ( 1997; ). Characterization of monoclonal antibody-escape mutants of tick-borne encephalitis virus with reduced neuroinvasiveness in mice. Journal of General Virology 78, 31-37.
    [Google Scholar]
  12. Ina, Y., Mizokami, M., Ohba, K. & Gojobori, T. ( 1994; ). Reduction of synonymous substitutions in the core protein gene of hepatitis C virus. Journal of Molecular Evolution 38, 50-56.
    [Google Scholar]
  13. Kariwa, H., Yoshizumi, S., Arikawa, J., Yoshimatsu, K., Takahashi, K., Takashima, I. & Hashimoto, N. ( 1995; ). Evidence for the existence of Puumula-related virus among Clethrionomys rufocanus in Hokkaido, Japan. American Journal of Tropical Medicine and Hygiene 53, 222-227.
    [Google Scholar]
  14. Korenberg, E. I. ( 1976; ). Some contemporary aspects of natural focality and epidemiology of tick-borne encephalitis. Folia Parasitologica 23, 357-366.
    [Google Scholar]
  15. Korenberg, E. I., Horakova, M., Kovalevsky, J. V., Hubalek, Z. & Karavanov, A. S. ( 1992; ). Probability models of the rate of infection with tick-borne encephalitis virus in Ixodes persulcatus ticks. Folia Parasitologica 39, 85-92.
    [Google Scholar]
  16. Li, W. H., Tanimura, M. & Sharp, P. M. ( 1988; ). Rates and dates of divergence between AIDS virus nucleotide sequences. Molecular Biology and Evolution 5, 313-330.
    [Google Scholar]
  17. McGuire, K., Holmes, E. C., Gao, G. F., Reid, H. W. & Gould, E. A. ( 1998; ). Tracing the origins of louping ill virus by molecular phylogenetic analysis. Journal of General Virology 79, 981-988.
    [Google Scholar]
  18. McMinn, P. C. ( 1997; ). The molecular basis of virulence of the encephalitogenic flaviviruses. Journal of General Virology 78, 2711-2722.
    [Google Scholar]
  19. Miyamoto, K., Nakao, M., Fujita, H. & Sato, H. ( 1993; ). The ixodid ticks on migratory birds in Japan and isolation of Lyme disease spirochetes from bird-feeding ticks. Japanese Journal of Sanitary Zoology 44, 315-326.
    [Google Scholar]
  20. Nei, M. & Gojobori, T. ( 1986; ). Simple methods for estimating the numbers of synonymous and nonsynonymous nucleotide substitutions. Molecular Biology and Evolution 3, 418-426.
    [Google Scholar]
  21. Pletnev, A. G., Yamshchikov, V. F. & Blinov, V. M. ( 1990; ). Nucleotide sequence of the genome and complete amino acid sequence of the polyprotein of tick-borne encephalitis virus. Virology 174, 250-263.[CrossRef]
    [Google Scholar]
  22. Rey, F. A., Heinz, F. X., Mandl, C., Kunz, C. & Harrison, S. C. ( 1995; ). The envelope glycoprotein from tick-borne encephalitis virus at 2 Å resolution. Nature 375, 291-298.[CrossRef]
    [Google Scholar]
  23. Saitou, N. & Nei, M. ( 1987; ). The neighbor-joining method: a new method for reconstructing phylogenetic trees. Molecular Biology and Evolution 4, 406-425.
    [Google Scholar]
  24. Shope, R. E. ( 1980; ). Medical significance of togaviruses: an overview of diseases caused by togaviruses in man and domestic and wild vertebrate animals. In The Togaviruses, pp. 47-82. Edited by R. W. Schlesinger. New York: Academic Press.
  25. Takashima, I., Morita, K., Chiba, M., Hayasaka, D., Sato, T., Takezawa, C., Igarashi, A., Kariwa, H., Yoshimatsu, K., Arikawa, J. & Hashimoto, N. ( 1997; ). A case of tick-borne encephalitis in Japan and isolation of the virus. Journal of Clinical Microbiology 35, 1943-1947.
    [Google Scholar]
  26. Takeda, T., Ito, T., Chiba, M., Takahashi, K., Niioka, T. & Takashima, I. ( 1998; ). Isolation of tick-borne encephalitis virus from Ixodes ovatus (Acari: Ixodidae) in Japan. Journal of Medical Entomology 35, 227-231.[CrossRef]
    [Google Scholar]
  27. Takeda, T., Ito, T., Osada, M., Takahashi, K. & Takashima, I. ( 1999; ). Isolation of tick-borne encephalitis virus from wild rodents and a seroepizootiologic survey in Hokkaido, Japan. American Journal of Tropical Medicine and Hygiene 60, 287-291.
    [Google Scholar]
  28. Wallner, G., Mandl, C. W., Ecker, M., Holzmann, H., Stiasny, K., Kunz, C. & Heinz, F. X. ( 1996; ). Characterization and complete genome sequences of high- and low-virulence variants of tick-borne encephalitis virus. Journal of General Virology 77, 1035-1042.[CrossRef]
    [Google Scholar]
  29. Zanotto, P. M., Gao, G. F., Gritsun, T., Marin, M. S., Jiang, W. R., Venugopal, K., Reid, H. W. & Gould, E. A. ( 1995; ). An arbovirus cline across the northern hemisphere. Virology 210, 152-159.[CrossRef]
    [Google Scholar]
  30. Zanotto, P. M., Gould, E. A., Gao, G. F., Harvey, P. H. & Holmes, E. C. ( 1996; ). Population dynamics of flaviviruses revealed by molecular phylogenies. Proceedings of the National Academy of Sciences, USA 93, 548-553.[CrossRef]
    [Google Scholar]
  31. Zilber, L. A. & Soloviev, V. D. (1946). Far Eastern tick-borne spring-summer (spring) encephalitis. American Review of Soviet Medicine Special, 1–80.
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