A recombinant measles virus expressing biologically active human interleukin-12.

References

1. Addae M. M., Komada Y., Zhang X. L., Sakurai M. 1995; Immunological unresponsiveness and apoptotic cell death of T cells in measles virus infection. Acta Paediatrica Japonica 37:308–314
   [Google Scholar]
2. Anderson R., Macdonald I., Corbet T., Hacking G., Lowdell M. W., Prentice H. G. 1997; Construction and biological characterization of an interleukin-12 fusion protein (Flexi-12) – delivery to acute myeloid leukemic blasts using adeno-associated virus. Human Gene Therapy 8:1125–1135
   [Google Scholar]
3. Atkins M. B., Robertson M. J., Gordon M., Lotze M. T., DeCoste M., DuBois J. S., Ritz J., Sandler A. B., Edington H. B., Garzone P. D., Mier J. W., Canning C. M., Battiato L., Tahara H., Sherman M. L. 1997; Phase I evaluation of intravenous recombinant human interleukin 12 in patients with advanced malignancies. Clinical Cancer Research 3:409–417
   [Google Scholar]
4. Auwaerter P. G., Kaneshima H., McCune J. M., Wiegand G., Griffin D. E. 1996; Measles virus infection of thymic epithelium in the SCID-hu mouse leads to thymocyte apoptosis. Journal of Virology 70:3734–3740
   [Google Scholar]
5. Bartz R., Brinckmann U., Dunster L., Rima B., Ter Meulen V., Schneider-Schaulies J. 1996; Mapping amino acids of the measles virus hemagglutinin responsible for receptor (CD46) downregulation. Virology 224:334–337
   [Google Scholar]
6. Brunda M. J., Luistro L., Rumennik L., Wright R. B., Dvorozniak M., Aglione A., Wigginton J. M., Wiltrout R. H., Hendrzak J. A., Palleroni A. V. 1996; Antitumor activity of interleukin 12 in preclinical models. Cancer Chemotherapy and Pharmacology 38:S16–21
   [Google Scholar]
7. Cattaneo R., Rebmann G., Baczko K., ter Meulen V., Billeter M. A. 1987; Altered ratios of measles virus transcripts in diseased human brains. Virology 160:523–526
   [Google Scholar]
8. Cavanaugh V. J., Guidotti L. G., Chisari F. V. 1997; Interleukin-12 inhibits hepatitis B virus replication in transgenic mice. Journal of Virology 71:3236–3243
   [Google Scholar]
9. Esolen L.M., Park S.W., Hardwick J.M., Griffin D. E. 1995; Apoptosis as a cause of death in measles virus-infected cells. Journal of Virology 69:3955–3958
   [Google Scholar]
10. Fugier-Vivier I., Servet-Delprat C., Rivailler P., Rissoan M. C., Liu Y. J., Rabourdin-Combe C. 1997; Measles virus suppresses cell-mediated immunity by interfering with the survival and functions of dendritic and T cells. Journal of Experimental Medicine 186:813–823
    [Google Scholar]
11. Griffin D. E., Bellini W. J. 1996; Measles virus. In Fields Virology pp 1267–1312 Edited by Fields B. N., Knipe D. M., Howley P. M. Philadelphia: Lippincott-Raven;
    [Google Scholar]
12. Griffin D. E., Ward B. J. 1993; Differential CD4 T cell activation in measles. Journal of Infectious Diseases 168:275–281
    [Google Scholar]
13. Grosjean I., Caux C., Bella C., Berger I., Wild F., Banchereau J., Kaiserlian D. 1997; Measles virus infects human dendritic cells and blocks their allostimulatory properties for CD4 + T cells. Journal of Experimental Medicine 186:801–812
    [Google Scholar]
14. Hemmi S., Geertsen R., Mezzacasa A., Peter I., Dummer R. 1998; The presence of HCAR (human coxsackievirus and adenovirus receptor) is associated with efficient adenovirus-mediated transgene expression in human melanoma cells. Human Gene Therapy (in press)
    [Google Scholar]
15. Hirsch R. L., Griffin D. E., Johnson R. T., Cooper S. J., Lindo de Soriano I., Roedenbeck S., Vaisberg A. 1984; Cellular immune responses during complicated and uncomplicated measles virus infections of man. Clinical Immunology and Immunopathology 31:1–12
    [Google Scholar]
16. Hoffman S. L., Crutcher J. M., Puri S. K., Ansari A. A., Villinger F., Franke E. D., Singh P. P., Finkelman F., Gately M. L., Dutta G. P., Sedegah M. 1997; Sterile protection of monkeys against malaria after administration of interleukin-12. Nature Medicine 3:80–83
    [Google Scholar]
17. Hussey G. D., Goddard E. A., Hughes J., Ryon J. J., Kerran M., Carelse E., Strebel P. M., Markowitz L. E., Moodie J., Barron P., Latief Z., Sayed R., Beatty D., Griffin D. E. 1996; The effect of Edmonston–Zagreb and Schwarz measles vaccines on immune response in infants. Journal of Infectious Diseases 173:1320–1326
    [Google Scholar]
18. Joseph B. S., Lampert P. W., Oldstone M. B. 1975; Replication and persistence of measles virus in defined subpopulations of human leukocytes. Journal of Virology 16:1638–1649
    [Google Scholar]
19. Karp C. L., Wysocka M., Wahl L. M., Ahearn J. M., Cuomo P. J., Sherry B., Trinchieri G., Griffin D. E. 1996; Mechanism of suppression of cell-mediated immunity by measles virus. Science 273:228–231
    [Google Scholar]
20. Lecouturier V., Fayolle J., Caballero M., Carabana J., Celma M., Fernandez-Munoz R., Wild T., Buckland R. 1996; Identification of two amino acids in the hemagglutinin glycoprotein of measles virus (MV) that govern hemadsorption, HeLa cell fusion, and CD46 downregulation: phenotypic markers that differentiate vaccine and wild-type MV strains. Journal of Virology 70:4200–4204
    [Google Scholar]
21. Macatonia S. E., Hosken N. A., Litton M., Vieira P., Hsieh C. S., Culpepper J. A., Wysocka M., Trinchieri G., Murphy K. M., O’Garra A. 1995; Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells. Journal of Immunology 154:5071–5079
    [Google Scholar]
22. McChesney M. B., Kehrl J. H., Valsamakis A., Fauci A. S., Oldstone M. B. 1987; Measles virus infection of B lymphocytes permits cellular activation but blocks progression through the cell cycle. Journal of Virology 61:3441–3447
    [Google Scholar]
23. McChesney M. B., Altman A., Oldstone M. B. 1988; Suppression of T lymphocyte function by measles virus is due to cell cycle arrest in G1. Journal of Immunology 140:1269–1273
    [Google Scholar]
24. Moss B., Elroy-Stein O., Mizukami T., Alexander W. A., Fuerst T. R. 1990; Product review: new mammalian expression vectors. Nature 348:91–92
    [Google Scholar]
25. Murakami Y., Seya T., Kurita M., Fukui A., Ueda S., Nagasawa S. 1998; Molecular cloning of membrane cofactor protein (MCP; CD46) on B95a cell, an Epstein–Barr virus-transformed marmoset B cell line: B95a-MCP is susceptible to infection by the CAM, but not the Nagahata strain of the measles virus. Biochemical Journal 330:1351–1359
    [Google Scholar]
26. Niewiesk S., Eisenhuth I., Fooks A., Clegg J. C., Schnorr J. J., Schneider-Schaulies S., ter Meulen V. 1997; Measles virus-induced immune suppression in the cotton rat (Sigmodon hispidus) model depends on viral glycoproteins. Journal of Virology 71:7214–7219
    [Google Scholar]
27. Radecke F., Spielhofer P., Schneider H., Kaelin K., Christiansen G., Huber M., Dotsch C., Billeter M. A. 1995; Rescue of infectious measles viruses from cloned DNA. EMBO Journal 14:5773–5784
    [Google Scholar]
28. Ryffel B. 1997; Interleukin-12-role of interferon-gamma in IL-12 adverse effects. Clinical Immunology and Immunopathology 83:18–20
    [Google Scholar]
29. Schlender J., Schnorr J. J., Spielhofer P., Cathomen T., Cattaneo R., Billeter M. A., Ter Meulen V., Schneider-Schaulies S. 1996; Interaction of measles virus glycoproteins with the surface of uninfected peripheral blood lymphocytes induces immunosuppression in vitro. Proceedings of the National Academy of Sciences, USA 93:13194–13199
    [Google Scholar]
30. Schmid A., Spielhofer P., Cattaneo R., Baczko K., Ter Meulen V., Billeter M. A. 1992; Subacute sclerosing panencephalitis is typically characterized by alterations in the fusion protein cytoplasmic domain of the persisting measles virus. Virology 188:910–915
    [Google Scholar]
31. Schnorr J. J., Xanthakos S., Keikavoussi P., Kampgen E., ter Meulen V., Schneider-Schaulies S. 1997; Induction of maturation of human blood dendritic cell precursors by measles virus is associated with immunosuppression. Proceedings of the National Academy of Sciences, USA 94:5326–5331
    [Google Scholar]
32. Starr S., Berkovitch S. 1964; Effect of measles, gammaglobulin-modified measles and vaccine measles on the tuberculin test. New England Journal of Medicine 270:386–391
    [Google Scholar]
33. Tamashiro V. G., Perez H. H., Griffin D. E. 1987; Prospective study of the magnitude and duration of changes in tuberculin reactivity during uncomplicated and complicated measles. Pediatric Infectious Disease Journal 6:451–454
    [Google Scholar]
34. Trinchieri G. 1998; Proinflammatory and immunoregulatory functions of interleukin-12. International Reviews of Immunology 16:365–396
    [Google Scholar]
35. Ward B. J., Johnson R. T., Vaisberg A., Jauregui E., Griffin D. E. 1991; Cytokine production in vitro and the lymphoproliferative defect of natural measles virus infection. Clinical Immunology and Immunopathology 61:236–248
    [Google Scholar]
36. Whittle H. C., Dossetor J., Oduloju A., Bryceson A. D., Greenwood B. M. 1978; Cell-mediated immunity during natural measles infection. Journal of Clinical Investigation 62:678–684
    [Google Scholar]