Mithramycin inhibited RNA synthesis in chick embryo cells in culture almost as efficiently as actinomycin D, although inhibition was considerably delayed. There was no direct effect on cellular protein synthesis. Mithramycin interfered with the multiplication of fowl plague virus (influenza A) but had little effect on the multiplication of Newcastle disease virus (parainfluenza). Ten µg./ml. of mithramycin, when added immediately after infection, preferentially inhibited the synthesis of fowl plague minus strand RNA in culture, but it had only a slight effect on the production of plus strand RNA. The synthesis of virus RNA-dependent RNA polymerase and RNP-antigen was only slightly inhibited, while the production of haemagglutinin and neuraminidase was strongly affected.


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