1887

Abstract

Bushpigs and warthogs are natural reservoir hosts of African swine fever virus (ASFV) in the wild, showing no clinical signs of disease when infected with the same highly virulent isolates of ASFV that induce rapid, haemorrhagic death in domestic pigs. In contrast to domestic pigs, infection of bushpigs with Malawi isolate results in low levels of virus replication and lymphocyte apoptosis within the spleen, and a relatively low spread of virus to other lymphoid tissues. However, at 10 days post-infection, a high degree of apoptosis was seen in B lymphocytes of the B cell follicles in bushpig lymph nodes. Virus infected cells were present amongst the apoptotic B cells of these follicles, suggesting that indirect factors released from ASFV infected macrophages signal surrounding lymphocytes to enter apoptosis. The susceptibility/resistance of domestic pigs/bushpigs to ASFV may serve as a unique veterinary model for the recently emerging haemorrhagic disease of man.

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/content/journal/jgv/10.1099/0022-1317-79-6-1439
1998-06-01
2024-11-09
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References

  1. Anderson E. C., Hutchings G., Mukarati N., Wilkinson P. J. 1998; African swine fever virus infection of the bushpig (Potamchoerus porous) and their significance in the epidemiology of the disease. Veterinary Microbiology in press
    [Google Scholar]
  2. Carrasco L., Chacon M., de Lara F., Martin de las Mulas J., Gomez-Villamandos J. C., Perez J., Wilkinson P. J., Sierra M. A. 1996; Apoptosis in lymph nodes in acute African swine fever. Journal of Comparative Pathology 115:415–428
    [Google Scholar]
  3. Cobbold C., Whittle J. T., Wileman T. 1996; Involvement of the endoplasmic reticulum in the assembly and envelopment of African swine fever virus. Journal of Virology 70:8382–8390
    [Google Scholar]
  4. DeTray D. E. 1963; African swine fever. Advances in Veterinary Science 8:299–333
    [Google Scholar]
  5. Haresnape J. M., Wilkinson P. J., Mellor P. S. 1984; Isolation of African swine fever virus from ticks of the Ornithodorus moubata complex (Ixodoidae: Argasidae) collected within the African swine fever enzootic area of Malawi. Epidemiology and Infection 101:173–185
    [Google Scholar]
  6. Montgomery R. E. 1921; On a form of swine fever occurring in British East Africa (Kenya colony). Journal of Comparative Pathology 34:243–262
    [Google Scholar]
  7. Oura C. A. L., Powell P. P., Parkhouse R. M. E. 1998a; African swine fever: a disease characterized by apoptosis. Journal of General Virology 79:1427–1438
    [Google Scholar]
  8. Oura C. A. L., Powell P. P., Parkhouse R. M. E. 1998b; Detection of African swine fever virus in infected pig tissues by immuno- cytochemistry and in situ hybridisation. Journal of Virological Methods in press
    [Google Scholar]
  9. Plowright W. 1977; Vector transmission of African swine fever virus. In Hog Cholera/Classical Swine Fever and African Swine Fever EEC Publication EUR 5904 EN pp. 575–587 Liess B. Edited by Luxembourg: Office for Official Publications of the European Communities;
    [Google Scholar]
  10. Saalmuller A. 1996; Characterisation of swine leukocyte differentiation antigens. Immunology Today 17:352–354
    [Google Scholar]
  11. Thomson G. R. 1985; The epidemiology of ASF: the role of free-living hosts in Africa. Onderstepoort Journal of Veterinary Research 52:201
    [Google Scholar]
  12. Thomson G. R., Gainaru M. D., Van Dellen A. F. 1980; Experimental infection of warthog (Phacochoerus aethiopicus) with ASFV. Onderstepoort Journal of Veterinary Research 47:19–22
    [Google Scholar]
  13. Wilkinson P. J., Donaldson A. I., Greig A., Bruce W. 1977; Transmission studies with African swine fever virus. Infection of pigs by airborne virus. Journal of Comparative Pathology 87:487–495
    [Google Scholar]
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