1887

Abstract

HPRS-103, the prototype of avian leukosis virus (ALV) subgroup J, was isolated in 1989 from meat-type chickens from commercial flocks where it induces myelocytic myeloid leukosis (ML). The HPRS-103 gene differs considerably from other ALV subgroups but shows high identity (75–97%) to -like sequences of the different members of the EAV family of endogenous avian retroviruses. Recently, we have isolated several viruses related to HPRS-103 from cases of ML. Although these isolates showed properties of ALV subgroup J, the majority of them resisted neutralization by HPRS-103-specific serum, suggesting antigenic variation. The nucleotide sequence of the gene of the variant viruses showed several substitutions resulting in amino acid changes especially clustered in the variable regions and . Analysis of the data suggests that selection pressure, probably from the immune response, is driving the antigenic variation among the isolates. Phylogenetic analysis of the sequences showed the evolutionary relationships of the isolates with HPRS-103 and the EAV family of endogenous avian retroviruses. The epidemiological significance of the antigenic variation and the emergence of variant viruses are discussed.

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1998-04-01
2022-05-21
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References

  1. Arendrup M., Sonnerborg A., Svennerholm B., Akerblom L., Nielsen C., Clausen H., Olofsson S., Nielsen J. O., Hansen J. E. 1993; Neutralizing antibody response during human immunodeficiency virus type 1 infection: type and group specificity and viral escape. Journal of General Virology 74:855–863
    [Google Scholar]
  2. Arshad S. S., Howes K., Barron G. S., Smith L. M., Russel P. H., Payne L. N. 1997; Tissue tropism of the HPRS-103 strain of J subgroup avian leukosis virus and of a derivative acutely transforming virus. Veterinary Pathology 34:127–137
    [Google Scholar]
  3. Bai J., Howes K., Payne L. N., Skinner M. A. 1995a; Sequence of host range determinants in the env gene of a full-length infectious proviral clone of exogenous avian leukosis virus HPRS-103 confirms that it represents a new subgroup (designated J). Journal of General Virology 76:181–187
    [Google Scholar]
  4. Bai J., Payne L. N., Skinner M. A. 1995b; HPRS-103 (exogenous avian leukosis virus subgroup J) has env gene related to those of endogenous elements EAV-0 and E51 and an E element found previously only in sarcoma viruses. Journal of Virology 69:779–784
    [Google Scholar]
  5. Bonhoeffer S., Holmes E. C., Nowak M. A. 1995; Causes of HIV diversity. Nature 376:125
    [Google Scholar]
  6. Bova C. A., Manfredi J. P., Swanstrom R. 1986; Env genes of avian retroviruses : nucleotide sequence and molecular recombinants define host range determinants. Virology 152:343–354
    [Google Scholar]
  7. Bova C. A., Olsen J. C., Swanstrom R. 1988; The avian retrovirus env gene family : molecular analysis of host range and antigenic variants. Journal of Virology 62:75–83
    [Google Scholar]
  8. Bova-Hill C., Olsen J. C., Swanstrom R. 1991; Genetic analysis of the Rous sarcoma virus subgroup D env gene: mammal tropism correlates with the temperature sensitivity of gp85. Journal of Virology 65:2073–2080
    [Google Scholar]
  9. Crittenden L. B., Eagen D. A., Gulvas F. A. 1979; Assays for endogenous and exogenous lymphoid leukosis viruses and chick helper factor with RSV(-) cell lines. Infection and Immunity 24:379–384
    [Google Scholar]
  10. Domingo E., Diez J., Martinez M. A., Hernandez J., Holguin A., Borrego B., Mateu M. G. 1993; New observation on antigenic diversification of RNA viruses. Antigenic variation is not dependent on immune selection. Journal of General Virology 74:2039–2045
    [Google Scholar]
  11. Dorner A. J., Coffin J. M. 1986; Determinants for receptor interaction and cell killing on the avian retrovirus glycoprotein gp85. Cell 45:365–374
    [Google Scholar]
  12. Duarte E. A., Novella I. S., Weaver S. C., Domingo E., Wain-Hobson S., Clarke D. K., Moya A., Elena S. F., de la Torre J. C., Holland J. 1994; RNA virus quasispecies : significance for viral disease and epidemiology. Infectious Agents and Disease 3:201–214
    [Google Scholar]
  13. Fadly A. M. 1989; Leukosis and sarcomas. In A Laboratory Manual for the Isolation and Identification of Avian Pathogens pp. 135–142 Purchase H. G., Arp L. H., Domermuth C. H., Pearson J. E. Edited by Dubuque, Iowa: American Association of Avian Pathologists-Kendall/Hunt;
    [Google Scholar]
  14. Ishizaki R., Vogt P. K. 1966; Immunological relationships among envelope antigens of avian tumour viruses. Virology 30:375–379
    [Google Scholar]
  15. Leamnson R. N., Halpern M. S. 1976; Subunit structure of the glycoprotein complex of avian tumor virus. Journal of Virology 18:956–968
    [Google Scholar]
  16. Nichol S. 1996; RNA viruses. Life on the edge of catastrophe. Nature 384:218–219
    [Google Scholar]
  17. Osborne R., Rigby M., Siebelink K., Neil J. C., Jarret O. 1994; Virus neutralization reveals antigenic variation among feline immunodeficiency virus isolates. Journal of General Virology 75:3641–3645
    [Google Scholar]
  18. Payne L. N., Holmes A., Howes K., Pattison M., Walters D. E. 1979; Studies on the associations between natural infection of hens, cocks and their progeny with lymphoid leukosis virus. Avian Pathology 8:411–424
    [Google Scholar]
  19. Payne L. N., Howes K., Adene D. F. 1985; A modified feather pulp culture method for determining the genetic susceptibility of adult chickens to leukosis-sarcoma viruses. Avian Pathology 14:261–267
    [Google Scholar]
  20. Payne L. N., Brown S. R., Bumstead N., Howes K., Frazier J. A., Thouless M. E. 1991a; A novel subgroup of exogenous avian leukosis virus in chickens. Journal of General Virology 72:801–807
    [Google Scholar]
  21. Payne L. N., Howes K., Gillespie A. M., Smith L. M. 1991b; Host range of Rous sarcoma virus pseudotype RSV (HPRS-103) in 12 avian species : support for a new avian retrovirus envelope subgroup, designated J. Journal of General Virology 73:2995–2997
    [Google Scholar]
  22. Payne L. N., Gillespie A. M., Howes K. 1992; Myeloid leukaemo-genicity and transmission of HPRS-103 strain of avian leukosis virus. Leukaemia 6:1167–1176
    [Google Scholar]
  23. Price D. A., Goulder P. J. R., Klenerman P., Sewell A. K., Easterbrook P. J., Troop M., Bangham C. R. M., Phillips R. E. 1997; Positive selection of HIV-1 cytotoxic T lymphocyte escape variants during primary infection. Proceedings of the National Academy of Sciences, USA 94:1890–1895
    [Google Scholar]
  24. Rong L., Edinger A., Bates B. 1997; Role of basic residues in the subgroup-determining region of the subgroup A avian sarcoma and leukosis virus envelope in receptor binding and infection. Journal of Virology 71:3458–3465
    [Google Scholar]
  25. Shpaer E. G., Mullins J. I. 1993; Rates of amino acid change in the envelope protein correlate with the pathogenicity of primate lentiviruses. Journal of Molecular Evolution 37:57–65
    [Google Scholar]
  26. Spencer J. L. 1984; Progress towards eradication of lymphoid leukosis viruses-a Review. Avian Pathology 13:599–607
    [Google Scholar]
  27. Spencer J. L. 1987; Laboratory diagnostic procedures for detecting avian leukosis virus infections. In Avian Leukosis pp. 213–235 De Boer G. F. Edited by Boston: Martinus Nijhoff;
    [Google Scholar]
  28. Valesia-Wittmann S., Drynda A., Deleage G., Aumailley M., Heard J. M., Danos O., Verdier G., Cosset F. 1994; Modifications in the binding domain of avian retrovirus envelope protein to redirect host range of retroviral vectors. Journal of Virology 68:4609–4619
    [Google Scholar]
  29. Venugopal K., Howes K., Barron G. S., Payne L. N. 1997; Recombinant env-gp85 of HPRS-103 (subgroup J) avian leukosisvirus : antigenic characteristics and usefulness as a diagnostic reagent. Avian Diseases 41:283–288
    [Google Scholar]
  30. Wolinsky S. M., Korber B. T., Neumann A. U., Daniels M., Kunstman K. J., Whetsell A. J., Furtado M. R., Cao Y., Ho D. D., Safrit J. T. 1996; Adapt ive evolution of human immunodeficiency virus-type 1 during the natural course of infection. Science 272:537–542
    [Google Scholar]
  31. Zhang Z., Du Tremblay D., Lang B. F., Martineau D. 1996; Phylogenetic and epidemiologic analysis of the walleye dermal sarcoma virus. Virology 225:406–412
    [Google Scholar]
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