1887

Abstract

To investigate the transferability of macrophage (Mϕ)-tropism among primate lentiviruses, we constructed recombinants of human immunodeficiency virus type 1 (HIV-1), simian immunodeficiency virus strain mac (SIVmac) and chimeric HIV-1/SIVmac (SHIV) having region Mϕ-tropic determinants. A recombinant HIV-1 having partially derived from a Mϕ-tropic HIV-1 strain (JR-FL) replicated in human macrophages but not in monkey macrophages. Conversely, a recombinant SIVmac having from a Mϕ-tropic strain (SIVmac316) replicated in monkey macrophages but not in human macrophages. A new SHIV (designated NM-3rN/JRFL) carrying the LTR and and of SIVmac and and of HIV-1 with partially replaced by that of JR-FL was replication-competent in human macrophages but not in monkey macrophages. These results suggest that the Mϕ-tropic determinant is specific to each host species and that the mechanism of Mϕ-tropism is different between HIV and SIV.

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1998-04-01
2022-09-29
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