1887

Abstract

In small RNA viruses, arm-like segments located at the N or C termini have been suggested as mediators in the assembly of the capsid proteins. In many cases the arms of several subunits converge at a common point (the symmetry axis). Recent advances in studies of the hepatitis B virus (HBV) core protein attest the convergence of the segments preceding the protamine region, around the symmetry axis, where five or six HBc protein subunits converge. We report a mutation study of the region that we have suggested forms an armlike structure, which reveals that a single mutation, Pro →138 Gly, prevents the full-length HBV core protein self-assembling into particles.

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/content/journal/jgv/10.1099/0022-1317-79-3-587
1998-03-01
2021-10-18
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