The large T antigen of simian virus 40 binds and inactivates p53 but not p73.

References

1. Bian J., Sun Y. 1997; p53CP, a putative p53 competing protein that specifically binds to the consensus p53 DNA binding sites: a third member of the p53 family?. Proceedings of the National Academy of Sciences, USA 94:14753–14758
   [Google Scholar]
2. Bollag B., Chuke W. F., Frisque R. J. 1989; Hybrid genomes of the polyomaviruses JC virus, BK virus, and simian virus 40 : identification of sequences important for efficient transformation. Journal of Virology 63:863–872
   [Google Scholar]
3. Carbone M., Rizzo P., Grimley P. M., Procopio A., Mew D. J., Shridhar V., de Bartolomeis A., Esposito V., Giuliano M. T., Steinberg S. M., Levine A. S., Giordano A., Pass H. I. 1997; Simian virus-40 large-T antigen binds p53 in human mesotheliomas. Nature Medicine 3:908–912
   [Google Scholar]
4. DeLuca A., Baldi A., Esposito V., Howard C. M., Bagella L., Rizzo P., Caputi M., Pass H. I., Giordano G. G., Baldi F., Carbone M., Giordano A. 1997; The retinoblastoma gene family pRb/p105, p107, pRb2/p130 and simian virus-40 large T antigen in human mesotheliomas. Nature Medicine 3:913–916
   [Google Scholar]
5. Dobbelstein M., Arthur A. K., Dehde S., vanZee K., Dickmanns A., Fanning E. 1992; Intracistronic complementation reveals a new function of SV40 T antigen that co-operates with Rb and p53 binding to stimulate DNA synthesis in quiescent cells. Oncogene 7:837–847
   [Google Scholar]
6. Jiang D., Srinivasan A., Lozano G., Robbins P. D. 1993; SV40 T antigen abrogates p53-mediated transcriptional activity. Oncogene 8:2805–2812
   [Google Scholar]
7. Jost C. A., Marin M. C., Kaelin W. G. Jr 1997; P73 isa human p53- related protein that can induce apoptosis. Nature 389:191–194
   [Google Scholar]
8. Kaelin W. G. Jr 1998; Another p53 Doppelganger?. Science 281:57–58
   [Google Scholar]
9. Kaghad M., Bonnet H., Yang A., Creancier L., Biscan J. C., Valent A., Minty A., Chalon P., Lelias J. M., Dumont X., Ferrara P., McKeon F., Caput D. 1997; Monoallelically expressed gene related to p53 at 1p36, a region frequently deleted in neuroblastoma and other human cancers. Cell 90:809–819
   [Google Scholar]
10. Kalderon D., Richardson W. D., Markham A. F., Smith A. E. 1984a; Sequence requirements for nuclear location ofsimian virus 40 large-T antigen. Nature 311:33–38
    [Google Scholar]
11. Kalderon D., Roberts B. L., Richardson W. D., Smith A. E. 1984b; A short amino acid sequence able to specify nuclear location. Cell 39:499–509
    [Google Scholar]
12. Lane D. P. 1992; p53, guardian of the genome. Nature 358:15–16
    [Google Scholar]
13. Levine A. J. 1997; p53, the cellular gatekeeper for growth and division. Cell 88:323–331
    [Google Scholar]
14. Li B., Fields S. 1993; Identification of mutations in p53 that affect its binding to SV40 large T antigen by using the yeast two-hybrid system. FASEB Journal 7:957–963
    [Google Scholar]
15. McCormick F., Clark R., Harlow E., Tjian R. 1981; SV40 T antigen binds specifically to a cellular 53 K protein in vitro. Nature 292:63–65
    [Google Scholar]
16. Mai M., Yokomizo A., Qian C., Yang P., Tindall D. J., Smith D. I., Liu W. 1988; Activation of p73 silent allele in lung cancer. Cancer Research 58:2347–2349
    [Google Scholar]
17. Mietz J. A., Unger T., Huibregtse J. M., Howley P. M. 1992; The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T antigen and by HPV-16 E6 oncoprotein. EMBO Journal 11:5013–5020
    [Google Scholar]
18. Nomoto S., Haruki N., Kondo M., Konishi H., Takahashi T. 1998; Search for mutations and examination of allelic expression imbalance of the p73 gene at 1p36. 33 in human lung cancers. Cancer Research 58:1380–1383
    [Google Scholar]
19. Osada M., Ohba M., Kawahara C., Ishioka C., Kanamaru R., Katoh I., Ikawa Y., Nimura Y., Nakagawara A., Obinata M., Ikawa S. 1998; Cloning and functional analysis of human p51, which structurally and functionally resembles p53. Nature Medicine 4:839–843
    [Google Scholar]
20. Paucha E., Kalderon D., Richardson W. D., Harvey R. W., Smith A. E. 1985; The abnormal location of cytoplasmic SV40 large T is not caused by failure to bind to DNA or to p53. EMBO Journal 4:3235–3240
    [Google Scholar]
21. Prabhu N. S., Somasundaram K., Satyamoorthy K., Herlyn M., El-Deiry W. S. 1998; p73, unlike p53, suppresses growth and induces apoptosis of human papillomavirus E6-expressing cancer cells. International Journal of Oncology 13:5–9
    [Google Scholar]
22. Sarnow P., Ho Y. S., Williams J., Levine A. J. 1982; Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells. Cell 28:387–394
    [Google Scholar]
23. Schmale H., Bamberger C. 1997; A novel protein with strong homology to the tumor suppressor p53. Oncogene 15:1363–1367
    [Google Scholar]
24. Staib C., Pesch J., Gerwig R., Gerber J. K., Brehm U., Stangl A., Grummt F. 1996; p53 inhibits JC virus DNA replication in vivo and interacts with JC virus large T antigen. Virology 219:237–246
    [Google Scholar]
25. Sunahara M., Ichimiya S., Nimura Y., Takada N., Sakiyama S., Sato Y., Todo S., Adachi W., Amano J., Nakagawara A. 1998; Mutational analysis of the p73 gene localized at chromosome 1p36. 3 in colorectal carcinomas. International Journal of Oncology 13:319–323
    [Google Scholar]
26. Takahashi H., Ichimiya S., Nimura Y., Watanabe M., Furusato M., Wakui S., Yatani R., Aizawa S., Nakagawara A. 1998; Mutation, allelotyping, and transcription analyses of the p73 gene in prostatic carcinoma. Cancer Research 58:2076–2077
    [Google Scholar]
27. Tan T. H., Wallis J., Levine A. J. 1986; Identification of the p53 protein domain involved in formation of the simian virus 40 large T antigen-p53 protein complex. Journal of Virology 59:574–583
    [Google Scholar]
28. Trink B., Okami K., Wu L., Sriuranpong V., Jen J., Sidransky D. 1998; A new human p53 homologue. Nature Medicine 4:747–748
    [Google Scholar]
29. Walker K. K., Levine A. J. 1996; Identification of a novel p53 functional domain that is necessary for efficient growth suppression. Proceedings of the National Academy of Sciences, USA 93:15335–15340
    [Google Scholar]
30. Wang X. W., Yeh H., Schaeffer L., Roy R., Moncollin V., Egly J. M., Wang Z., Freidberg E. C., Evans M. K., Taffe B. G. others 1995; p53 modulation of TFIIH-associated nucleotide excision repair activity. Nature Genetics 10:188–195
    [Google Scholar]
31. Wang X. W., Vermeulen W., Coursen J. D., Gibson M., Lupold S. E., Forrester K., Xu G., Elmore L., Yeh H., Hoeijmakers J. H., Harris C. C. 1996; The XPB and XPD DNA helicases are components of the p53-mediated apoptosis pathway. Genes & Development 10:1219–1232
    [Google Scholar]
32. Werness B. A., Levine A. J., Howley P. M. 1990; Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248:76–79
    [Google Scholar]
33. Yew P. R., Berk A. J. 1992; Inhibition of p53 transactivation required for transformation by adenovirus early 1B protein. Nature 357:82–5
    [Google Scholar]
34. Zeng X., Levine A. J., Lu H. 1998; Non-p53 p53RE binding protein, a human transcription factor functionally analogous to p53. Proceedings of the National Academy of Sciences, USA 95:6681–6686
    [Google Scholar]