1887

Abstract

Apoptosis induced by H-1 parvovirus infection was investigated in C6 rat glioblastoma cells and in newborn rats. Apoptotic changes, such as chromatin condensation, the appearance of apoptotic nuclear bodies and oligonucleosomal DNA ladders, were observed in infected C6 cells 2 days after infection. Inhibitor assay results suggest that a caspase-3-dependent apoptosis activation pathway is induced by H-1 virus infection in C6 cells. Observations made revealed that the number of apoptotic cells increased in the infected cerebellum, coinciding with known virus infection sites.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-79-12-3067
1998-12-01
2022-05-23
Loading full text...

Full text loading...

/deliver/fulltext/jgv/79/12/9880023.html?itemId=/content/journal/jgv/10.1099/0022-1317-79-12-3067&mimeType=html&fmt=ahah

References

  1. Asai A., Miyagi Y., Hashimoto H., Lee S. H., Mishima K., Sugiyama A., Tanaka H., Mochizuki T., Yasuda T., Kuchino Y., Kuchino Y. 1994a; Negative effects of wild-type p53 and s-Myc on cellular growth and tumorigenicity of glioma cells. Implication of the tumor suppressor genes for gene therapy. Journal of Neuro-Oncology 19:259–268
    [Google Scholar]
  2. Asai A., Miyagi Y., Sugiyama A., Gamanuma M., Hong S. H., Takamoto S., Nomura K., Matsutani M., Takakura K., Kuchino Y. 1994b; Negative effects of wild-type p53 and s-Myc on cellular growth and tumorigenicity of glioma cells. Implication of the tumor suppressor genes for gene therapy. Journal of Neuro-Oncology 19:259–268
    [Google Scholar]
  3. Caillet-Fauquet P., Perros M., Brandenburger A., Spegelaere P., Rommelaere J. 1990; Programmed killing of human cells by means of an inducible clone of parvoviral genes encoding non-structural proteins. EMBO Journal 9:2989–2995
    [Google Scholar]
  4. Doerig C., McMaster G., Sogo J., Bruggmann H., Beard P. 1986; Nucleoprotein complexes of minute virus of mice have a distinct structure different from that of chromatin. Journal of Virology 58:817–824
    [Google Scholar]
  5. Gaertner D. J., Jacoby R. O., Johnson E. A., Paturzo F. X., Smith A. L., Brandsma J. L. 1993; Characterization of acute rat parvovirus infection by in situ hybridization. Virus Research 28:1–18
    [Google Scholar]
  6. Gavrieli Y., Sherman Y., Ben-Sasson S. A. 1992; Identification of programmed cell death in situ via specific labelling of nuclear DNA fragmentation. Journal of Cell Biology 119:493–501
    [Google Scholar]
  7. Hirt B. 1967; Selective extraction of polyoma DNA from infected mouse cell culture. Journal of Molecular Biology 26:365–369
    [Google Scholar]
  8. Kagaya S., Kitanaka C., Noguchi K., Mochizuki T., Sugiyama A., Asai A., Yasuhara N., Eguchi Y., Tsujimoto Y., Kuchino Y. 1997; A functional role for death proteases in s-Myc- and c-Myc-mediated apoptosis. Molecular and Cellular Biology 17:6736–6745
    [Google Scholar]
  9. Kilham L., Margolis G. 1975; Problems of human concern arising from animal models of intrauterine and neonatal infections due to viruses : a review. I. Introduction and virologic studies. Progress in Medical Virology 20:113–143
    [Google Scholar]
  10. Koyama A. H., Adachi A. 1997; Induction of apoptosis by herpes simplex virus type 1. Journal of General Virology 78:2909–2912
    [Google Scholar]
  11. Legrand C., Mousset S., Salomé N., Rommelaere J. 1992; Cooperation of oncogenes in cell transformation and sensitization to killing by the parvovirus minute virus of mice. Journal of General Virology 73:2003–2009
    [Google Scholar]
  12. Levine B., Huang Q., Issacs J. T., Reed J. C., Griffin D. F., Hardwick J. M. 1993; Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene. Nature 361:739–742
    [Google Scholar]
  13. Lo Y. -M. D., Mehal W. Z., Fleming K. A. 1988; Rapid production of vector-free biotinylated probes using the polymerase chain reaction. Nucleic Acids Research 16:8719
    [Google Scholar]
  14. Margolis G., Kilham L. 1975; Problems of human concern arising from animal models of intrauterine and neonatal infections due to viruses: a review. II. Pathologic studies. Progress in Medical Virology 20:144–179
    [Google Scholar]
  15. Meyaard L., Otto S. A., Jonker R. R., Munster M. J., Keet R. P. M., Miedema F. 1992; Programmed death of T cells in HIV-1 infection. Science 257:217–219
    [Google Scholar]
  16. Miura M., Zhu H., Rottelo R., Hartweig E. A., Yuan J. 1993; Induction of apoptosis in fibroblasts by IL-1 beta-converting enzyme, a mammalian homolog of theC. eleganscell death gene ced-3. Cell 75:653–660
    [Google Scholar]
  17. Momoeda M., Wong S., Kawase M., Young N. S., Kajigaya S. 1994; A putative nucleoside triphosphate-binding domain in the nonstructural protein of B19 parvovirus is required for cytotoxicity. Journal of Virology 68:8443–8446
    [Google Scholar]
  18. Mousset S., Ouadrhiri Y., Caillet-Fauquet P., Rommelaere J. 1994; The cytotoxicity of the autonomous parvovirus minute virus of mice nonstructural proteins in FR3T3 rat cells depends on oncogene expression. Journal of Virology 68:6446–6453
    [Google Scholar]
  19. Nicholson D. W., Ali A., Thornberry N. A., Vaillancourt J. P., Ding C. K., Gareau Y., Gallant M., Griffin P. R., Labelle M., Lazebnik Y. A., Munday N. A., Raju S. M., Smulson M. E., Yamin T. T., Yu V. L., Miller D. K. 1995; Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376:37–43
    [Google Scholar]
  20. Noteborn M. H., Todd D., Verschueren C. A., deGauw H. W., Curran W. L., Veldkamp S., Douglas A. J., McNulty M. S., vanderEb A. J., Koch G. 1994; A single chicken anemia virus protein induces apoptosis. Journal of Virology 68:346–351
    [Google Scholar]
  21. Op De Beeck A., Caillet-Fauquet P. 1997; The NS1 protein of the autonomous parvovirus minute virus of mice blocks cellular DNA replication: a consequence of lesions to the chromatin?. Journal of Virology 71:5323–5329
    [Google Scholar]
  22. Resnicoff M., Burgaud J. -L., Rotman H. L., Abraham D., Baserga R. 1995; Correlation between apoptosis, tumorigenesis, and levels of insulin-like growth factor 1 receptors. Cancer Research 55:3739–3741
    [Google Scholar]
  23. Rommelaere J., Cornelis J. J. 1991; Antineoplastic activity of parvoviruses. Journal of Virological Methods 33:233–251
    [Google Scholar]
  24. Rommelaere J., Tattersall P. 1990; Oncosuppression by parvoviruses. In Handbook of Parvoviruses 2 pp 41–57 Tijssen P. Edited by Boca Raton, FL: CRC Press;
    [Google Scholar]
  25. Takizawa T., Matsukawa S., Higuchi Y., Nakamura S., Nakanishi Y., Fukuda R. 1993; Induction ofprogrammed cell death (apoptosis) by influenza virus infection in tissue culture cells. Journal of General Virology 74:2347–2355
    [Google Scholar]
  26. Telerman A., Tuynder M., Dupressoir T., Robaye B., Sigaux F., Shaulian E., Oren M., Rommelaere J., Amson R. 1993; A model for tumor suppression using H-1 parvovirus. Proceedings of the National Academy of Sciences, USA 90:8702–8706
    [Google Scholar]
  27. Toolan H. W. 1978; Maternal role in susceptibility of embryonic and newborn hamsters to H-1 parvovirus. In Replication of Mammalian Parvoviruses, pp 161–176 Ward D. C., Tattersall P. Edited by Cold Spring Harbor, NY: Cold Spring Harbor Laboratory;
    [Google Scholar]
  28. VanPachterbeke C., Tuynder M., Cosyn J. P., Lespagnard L., Larsimont D., Rommelaere J. 1993; Parvovirus H-1 inhibits growth of short-term tumor-derived but not normal mammary tissue cultures. International Journal of Cancer 55:672–677
    [Google Scholar]
  29. Yin D., Kondo S., Barnett G. H., Morimura T., Takeuchi J. 1995; Tumor necrosis factor-a induces p53-dependent apoptosis in rat glioma cells. Neurosurgery 37:758–763
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-79-12-3067
Loading
/content/journal/jgv/10.1099/0022-1317-79-12-3067
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error