1887

Abstract

Fowl adenovirus (FAdV) type 1, CELO strain has no homologies to mastadenovirus E1A, E1B, E3 and E4, which regulate virus gene expression, DNA replication and virus-host interaction. Similarly, the right 5 kb and left 15 kb ends of CELO virus DNA are non-homologousto mastadenoviruses. To compare CELO virus with another FAdV, 7·5 kb of the left and 17 kb of the right ends of FAdV type 8 (strain A-2A) were sequenced and nine and 17 open reading frames (ORFs), respectively, were found. This FAdV- 8 genome was similar to CELO virus in that (1) the central region contained the major structural protein genes including the fibre, pVIII, 100K, late 33K and pIVa2 genes, which were in the same order as in mastadenoviruses, (2) no homologues of mast adenovirus E1A, E1B, E3 and E4 were found in the ends, and (3) the left 6 kb and the right 13 kb ends showed no homology to mastadenoviruses. Several genomic features were unique to FAdV-8 compared to CELO virus. FAdV-8 contained one fibre gene in contrast to two in CELO virus. Three of eight unassigned ORFs in the left and five of 13 unassigned ORFs in the right ends were unique compared to CELO virus. Two sets of tandem repeats, one with five identical 33 bp repeats and the other with more than ten identical 135 bp repeats, mapped between 4·5 and 7·5 kb from the right terminus. No virus-associated RNA gene was found. Fifteen of 16 unique FAdV-8 ORFs tested were, as determined by RT-PCR, transcribed early.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-79-10-2507
1998-10-01
2024-03-28
Loading full text...

Full text loading...

/deliver/fulltext/jgv/79/10/9780058.html?itemId=/content/journal/jgv/10.1099/0022-1317-79-10-2507&mimeType=html&fmt=ahah

References

  1. Aleström P., Stenlund A., Li P., Bellett A., Pettersson U. 1982; Sequence homology between avian and human adenoviruses. Journal of Virology 42:306–310
    [Google Scholar]
  2. Alexander H. S., Huber P., Cao J. X., Krell P. J., Nagy É. 1998; Growth characteristics of fowl adenovirus type 8 on a chicken hepatoma cell line. Journal of Virological Methods in press
    [Google Scholar]
  3. Altschul S. F., Gish W., Miller W., Myers E. W., Lipman D. J. 1990; Basic local alignment search tool. Journal of Molecular Biology 215:403–410
    [Google Scholar]
  4. Baroudy B. M., Moss B. 1982; Sequence homologies of diverse length tandem repetitions near ends of vaccinia virus genome suggest unequal crossing over. Nucleic Acids Research 10:5673–5679
    [Google Scholar]
  5. Baroudy B. M., Venkatesan S., Moss B. 1982; Incompletely base- paired flip-flop terminal loops link the two DNA strands of the vaccinia virus genome into one uninterrupted polynucleotide chain. Cell 28:315–324
    [Google Scholar]
  6. Berns K. I. 1996; Parvoviridae: the viruses and their replication. In Fields Virology, 3rd edn. pp 2173–2197 Fields B. N., Knipe D. M., Howley P. M. Edited by Philadelphia: Lippincott-Raven;
    [Google Scholar]
  7. Bett A. J., Prevec L., Graham F. L. 1993; Packaging capability and stability of human adenovirus type 5 vector. Journal of Virology 67:5911–5921
    [Google Scholar]
  8. Challberg M. D., Rawlins D. R. 1984; Template requirements for the initiation of adenovirus DNA replication. Proceedings of the National Academy of Sciences, USA 81:100–104
    [Google Scholar]
  9. Chen M., Mermod N., Horwitz M. S. 1990; Protein-protein interactions between adenovirus DNA polymerase and nuclear factor-I mediate formation of the DNA replication preinitiation complex. Journal of Biological Chemistry 265:18634–18642
    [Google Scholar]
  10. Chiocca S., Kurzbauer R., Schaffner G., Baker A., Mautner V., Cotten M. 1996; The complete DNA sequence and genomic organization of the avian adenovirus CELO. Journal of Virology 70:2939–2949
    [Google Scholar]
  11. Chiocca S., Baker A., Cotten M. 1997; Identification of a novel antiapoptotic protein, GAM-1, encoded by the CELO adenovirus. Journal of Virology 71:3168–3177
    [Google Scholar]
  12. Clavijo A., Krell P. J., Nagy É. 1996; Molecular cloning and restriction enzyme mapping of avian adenovirus type 8 DNA. Virus Research 45:93–99
    [Google Scholar]
  13. Devereux J., Haeberli P., Smithies O. 1984; A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Research 12:387–395
    [Google Scholar]
  14. Gelderblom H., Maichle-Lauppe I. 1982; The fibers of fowl adenovirus. Archives of Virology 72:289–298
    [Google Scholar]
  15. Gooding L. R. 1992; Virus proteins that counteract host immune defenses. Cell 71:5–7
    [Google Scholar]
  16. Gräble M., Hearing P. 1990; Adenovirus type 5 packaging domain is composed of a repeated element that is functionally redundant. Journal of Virology 64:2047–2056
    [Google Scholar]
  17. Gräble M., Hearing P. 1992; Cis and trans requirements for the selective packaging of adenovirus type 5 DNA. Journal of Virology 66:723–731
    [Google Scholar]
  18. Hess M., Cuzange A., Ruigrok R. W. H., Chroboczek J., Jacrot B. 1995; The avian adenovirus penton: two fibers and one base. Journal of Molecular Biology 252:379–385
    [Google Scholar]
  19. Hess M., Blocker H., Brandt P. 1997; The complete nucleotide sequence of the egg drop syndrome virus : an intermediate between mastadenoviruses and aviadenoviruses. Virology 238:145–156
    [Google Scholar]
  20. Johnson G. P., Goebel S. J., Paoletti E. 1993; An update on the vaccinia virus genome. Virology 196:381–401
    [Google Scholar]
  21. Lally C., Dörper T., Gröger W., Antoine G., Winnacker E.-L. 1984; A size analysis of the adenovirus replicon. EMBO Journal 3:333–341
    [Google Scholar]
  22. Laver W. G., Younghusband H. B., Wrigley N. G. 1971; Purification and properties of chick embryo lethal orphan virus (an avian adenovirus). Virology 45:598–614
    [Google Scholar]
  23. Lichtenstein D. L., Rushlow K. E., Cook R. F., Raabe M. L., Swardson C. J., Kociba G. J., Issel C. J., Montelaro R. C. 1995; Replication in vitro and in vivo of an equine infectious anaemia virus mutant deficient in dUTPase activity. Journal of Virology 69:2881–2888
    [Google Scholar]
  24. McCracken R. M., Adair B. M. 1993; Avian adenovirus. In Virus Infection of Birds pp 123–144 McFerran J. B., McNulty M. S. Edited by Amsterdam: Elsevier;
    [Google Scholar]
  25. McFerran J. B., Adair B. M. 1977; Avian adenovirus - a review. Avian Pathology 6:189–217
    [Google Scholar]
  26. Massung R. F., Liu L.-I., Qi J., Knight J. C., Yuran T. E., Kerlavage A. R., Parsons J. M., Venter J. C., Esposito J. J. 1994; Analysis of the complete genome of smallpox variola major virus strain Bangladesh- 1975. Virology 201:215–240
    [Google Scholar]
  27. Moss B. 1996; Poxviridae : the viruses and their replication. In Fields Virology, 3rd edn. pp 2637–2671 Fields B. N., Knipe D. M., Howley P. M. Edited by Philadelphia: Lippincott-Raven;
    [Google Scholar]
  28. Mul Y. M., van der Vliet P. C. 1992; Nuclear factor I enhances adenovirus DNA replication by increasing the stability of a preinitiation complex. EMBO Journal 11:751–760
    [Google Scholar]
  29. Pallister J., Wright P. J., Sheppard M. 1996; A single gene encoding the fiber is responsible for variation in virulence in the fowl adenoviruses. Journal of Virology 70:5115–5122
    [Google Scholar]
  30. Parsons B. L., Pickup D. J. 1987; Tandemly repeated sequences are present at the ends of the DNA of raccoonpox virus. Virology 161:45–53
    [Google Scholar]
  31. Perkus M. E., Goebel S., Davis S., Johnson G. P., Norton E., Paoletti E. 1991; Deletion of fifty five open reading frames from the termini of vaccinia virus. Virology 180:406–410
    [Google Scholar]
  32. Pettersson U., Roberts R. J. 1986; Adenovirus gene expression and replication: a historical review. Cancer Cells 4:37–57
    [Google Scholar]
  33. Pickup D. J., Bastia D., Stone H. O., Joklik W. J. 1982; Sequence of terminal regions of cowpox virus DNA: arrangement of repeated and unique sequence elements. Proceedings of the National Academy of Sciences, USA 79:7112–7116
    [Google Scholar]
  34. Pyles R. B., Sawtell N. M., Thompson R. L. 1992; Herpes simplex virus type-1 dUTPase mutants are attenuated for neurovirulence, neuroinvasiveness, and reactivation from latency. Journal of Virology 66:6706–6713
    [Google Scholar]
  35. Roseman N. A., Slabaugh M. B. 1990; The vaccinia virus HindlII F fragment: nucleotide sequence of the left 6·2 kb. Virology 178:410–418
    [Google Scholar]
  36. Schmid S., Hearing P. 1997; Bipartite structure and functional independence of adenovirus type 5 packaging elements. Journal of Virology 71:3375–3384
    [Google Scholar]
  37. Scholz E., Welniak E., Nyholm T., Guo P. 1993; An avian hepatoma cell line for the cultivation of infectious laryngotracheitis virus and for expression of foreign genes with a mammalian promoter. Journal of Virological Methods 43:273–286
    [Google Scholar]
  38. Shenk T. 1996; Adenoviridae : the viruses and their replication. In Fields Virology, 3rd edn. pp 2111–2148 Fields B. N., Knipe D. M., Howley P. M. Edited by Philadelphia: Lippincott-Raven;
    [Google Scholar]
  39. Smith C. W. J., Patton J. G., Nadal-Ginard B. 1989; Alternative splicing in the control of gene expression. Annual Review of Genetics 23:527–577
    [Google Scholar]
  40. Tamanoi F. B., Stillman W. 1983; Initiation of adenovirus DNA replication in vitro requires a specific DNA sequence. Proceedings of the National Academy of Sciences, USA 80:6446–6450
    [Google Scholar]
  41. Temperley S. M., Hay R. T. 1992; Recognition of the adenovirus type 2 origin of DNA replication by the virally encoded DNA polymerase and preterminal proteins. EMBO Journal 11:761–768
    [Google Scholar]
  42. Threadgill D. S., Steagall W. K., Flaherty M. T., Fuller F. J., Perry S. T., Rushlow K. E., LeGrice S. F., Payne S. L. 1993; Charac-terization of equine infectious anaemia virus dUTPase : growth properties of a dUTPase-deficient mutant. Journal of Virology 67:2592–2600
    [Google Scholar]
  43. Turelli P., Pétursson G., Guiguen F., Mornex J. F., Vigne R., Quérat G. 1996; Replication properties of dUTPase-deficient mutants of caprine and ovine lentiviruses. Journal of Virology 70:1213–1217
    [Google Scholar]
  44. van Bergeen B. G. M., van der Ley P. A., van Driel W., van Mansfield A. D. M., van der Vliet P. C. 1983; Replication of origin containing adenovirus DNA fragments that do not carry the terminal protein. Nucleic Acids Research 11:1975–1989
    [Google Scholar]
  45. Weiss R. S., Lee S. S., Venkataram Prasad B. V. V., Javier R. T. 1997; Human adenovirus early region 4 open reading frame 1 genes encode growth-transforming proteins that may be distantly related to dUTPase pyrophosphatase enzymes. Journal of Virology 71:1857–1870
    [Google Scholar]
  46. Wittek R., Moss B. 1980; Tandem repeats within the inverted terminal repetition of vaccinia virus DNA. Cell 21:277–284
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-79-10-2507
Loading
/content/journal/jgv/10.1099/0022-1317-79-10-2507
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error