1887

Abstract

The nucleotide sequences of the nucleocapsid protein (NP) gene, the intergenic regions in the nucleocapsid protein (NP)-phosphoprotein (P), P-matrix protein (M) and M-fusion glycoprotein gene junctions and the trailer region of a virulent Newcastle disease virus (NDV) strain Beaudette C were determined. The NP gene is 1747 nt long and encodes a protein of 489 amino acids. Each of the intergenic sequences determined is 1 nt long and, including the previously published intergenic sequences, the gene junction sequences varied in length from 1– 47 nt and lacked any sequence identity. The 5′ trailer region is 113 nt in length. Comparison of the sequences of the terminal leader and trailer regions of Beaudette C strain with those of nonvirulent strain B1 showed a high level of conservation, indicating the likelihood of these elements not being a factor in virulence. Together with previously published data, this report completes the sequence of the 15 186 nt genomic RNA of NDV strain Beaudette C.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-79-10-2419
1998-10-01
2022-08-13
Loading full text...

Full text loading...

/deliver/fulltext/jgv/79/10/9780047.html?itemId=/content/journal/jgv/10.1099/0022-1317-79-10-2419&mimeType=html&fmt=ahah

References

  1. Alexander D. J. 1996; Paramyxoviridae. In Poultry Diseases, 4th edn. pp 139–155 Jordan F. T. W., Pattison M. Edited by London: W. B. Saunders;
    [Google Scholar]
  2. Baron M. D., Barrett T. 1995; Sequencing and analysis of the nucleocapsid (N) and polymerase (L) genes and the terminal extragenic domains of the vaccine strain of rinderpest virus. Journal of General Virology 76:593–602
    [Google Scholar]
  3. Blumberg B. M., Crowley J. C., Silverman J. I., Menonna J., Cook S. D., Dowling P. C. 1988; Measles virus L protein evidences elements of ancestral RNA polymerase. Virology 164:487–497
    [Google Scholar]
  4. Calain P., Roux L. 1993; The rule of six, a basic feature for efficient replication of Sendai virus defective interfering RNA. Journal of Virology 67:4822–4830
    [Google Scholar]
  5. Chambers P., Millar N. S., Bingham R. W., Emmerson P. T. 1986a; Molecular cloning of complementary DNA to Newcastle disease virus, and nucleotide sequence analysis of the junction between the genes encoding the haemagglutinin-neuraminidase and the large protein. Journal of General Virology 67:475–486
    [Google Scholar]
  6. Chambers P., Millar N. S., Emmerson P. T. 1986b; Nucleotide sequence of the gene encoding the fusion glycoprotein of Newcastle disease virus. Journal of General Virology 67:2685–2694
    [Google Scholar]
  7. Chambers P., Millar N. S., Platt S. G., Emmerson P. T. 1986c; Nucleotide sequence of the gene encoding the matrix protein of Newcastle disease virus. Nucleic Acids Research 14:9051–9061
    [Google Scholar]
  8. Collins P. L., Dickens L. E., Buckler-White A., Olmsted R. A., Spriggs M. K., Camargo E., Coelingh K. V. 1986; Nucleotide sequences for the gene junctions of human respiratory syncytial virus reveal distinctive features of intergenic structure and gene order. Proceedings of the National Academy of Sciences, USA 83:4594–4598
    [Google Scholar]
  9. Crowley J. C., Dowling P. C., Menonna J., Silverman J. I., Schuback D., Cook S. D., Blumberg B. M. 1988; Sequence variability and function of measles virus 3ʹ and 5ʹ and intercistronic regions. Virology 164:498–506
    [Google Scholar]
  10. Daskalakis S., Menke J., Stripp B., Stone H. 1992; Nucleotide sequence of the phosphoprotein gene of Newcastle disease virus (strain Beaudette C). Nucleic Acids Research 20:616
    [Google Scholar]
  11. Dorit R. L. 1995; cDNA amplification using one-sided PCR. In Current Protocols in Molecular Biology 2 pp 15.6.1–15.6.10 Ausubel F. M., Brent R., Kingston R. E., Moore D. D., Seidman J. G., Smith J. A., Struhl K. Edited by New York: John Wiley & Sons;
    [Google Scholar]
  12. Durbin A. P., Siew J. W., Murphy B. R., Collins P. L. 1997; Minimum protein requirements for transcription and RNA replication of a minigenome of human parainfluenza virus type 3 and evaluation of the rule of six. Virology 234:74–83
    [Google Scholar]
  13. Elango N., Varsanyi T. M., Kövamees J., Norrby E. 1988; Molecular cloning and characterization of six genes, determination of gene order and intergenic sequences and leader sequence of mumps virus. Journal of General Virology 69:2893–2900
    [Google Scholar]
  14. Galinski M. S., Mink M. A., Pons M. W. 1988; Molecular cloning and sequence analysis of the human parainfluenza virus 3 virus gene encoding the L protein. Virology 165:499–510
    [Google Scholar]
  15. Gupta K. C., Kingsbury D. W. 1984; Complete sequences of the intergenic and mRNA start signals in the Sendai virus genome : homologies with the genome of vesicular stomatitis virus. Nucleic Acids Research 12:3829–3841
    [Google Scholar]
  16. Ishida N., Taira H., Omata T., Mizumoto K., Hattori S., Iwasaki K., Kawakita M. 1986; Sequence of 2617 nucleotides from the 3ʹ end of Newcastle disease virus genome RNA and the predicted amino acid sequence of viral NP protein. Nucleic Acids Research 14:6551–6564
    [Google Scholar]
  17. Kawano M., Okamoto K., Bando H., Kondo K., Tsurudome M., Komada H., Nishio M., Ito Y. 1991; Characterization of the human parainfluenza type 2 virus gene encoding the L protein and the intergenic sequences. Nucleic Acids Research 19:2739–2746
    [Google Scholar]
  18. Kingsbury D. W. 1966; Newcastle disease virus RNA. I. Isolation and preliminary characterization of RNA from virus particles. Journal of Molecular Biology 18:195–203
    [Google Scholar]
  19. Kurilla M. G., Stone H. O., Keene J. D. 1985; RNA sequence and transcriptional properties of the 3ʹ end of the Newcastle disease virus genome. Virology 145:203–212
    [Google Scholar]
  20. Lamb R. A., Kolakofsky D. 1996; Paramyxoviridae: the viruses and their replication. In Fields Virology, 3rd edn. pp 1177–1203 Fields B. N., Knipe D. M., Howley P. M. Edited by Philadelphia: Lippincott-Raven;
    [Google Scholar]
  21. Millar N. S., Chambers P., Emmerson P. T. 1986; Nucleotide sequence analysis of the haemagglutinin-neuraminidase gene of Newcastle disease virus. Journal of General Virology 67:1917–1927
    [Google Scholar]
  22. Mink M. A., Stec D. S., Collins P. L. 1991; Nucleotide sequences of the 3ʹ leader and 5ʹ trailer regions of human respiratory syncytial virus genomic RNA. Virology 185:615–624
    [Google Scholar]
  23. Murphy F. A., Fauquet C. M., Bishop D. H. L., Ghabrial S. A., Jarvis A. W., Martelli G. P., Mayo M. A., Summers M. D. editors 1995 Virus Taxonomy. Sixth Report of the International Committee on Taxonomy of Viruses Vienna & New York: Springer-Verlag;
    [Google Scholar]
  24. Okazaki K., Tanabayashi K., Takeuchi K., Hishiyama M., Okazaki K., Yamada A. 1992; Molecular cloning and sequence analysis of the mumps virus gene encoding the L protein and the trailer sequence. Virology 188:926–930
    [Google Scholar]
  25. Parks G. D., Ward C. D., Lamb R. A. 1992; Molecular cloning of the NP and L genes of simian virus 5: identification of highly conserved domains in paramyxovirus NP and L protein. Virus Research 22:259–279
    [Google Scholar]
  26. Peeples M. E. 1988; Newcastle disease virus replication. In Newcastle Disease pp 45–78 Alexander D. J. Edited by Dordrecht: Kluwer Academic;
    [Google Scholar]
  27. Rozenblatt S., Eizenberg O., Ben-Levy R., Lavie V., Bellini W. J. 1985; Sequence homology within morbilliviruses. Journal of Virology 53:684–690
    [Google Scholar]
  28. Samal S. K., Collins P. L. 1996; RNA replication by a minigenome of respiratory syncytial virus (RSV) does not obey the ‘rule of six’ described for other paramyxoviruses. Journal of Virology 70:5075–5082
    [Google Scholar]
  29. Sanchez A., Banerjee A. K., Furuichi Y., Richardson M. A. 1986; Conserved structures among the nucleocapsid proteins of the para- myxoviridae: complete nucleotide sequence of human parainfluenza virus type 3 NP mRNA. Virology 152:171–180
    [Google Scholar]
  30. Sheshberadaran H., Lamb R. A. 1990; Sequence characterization of the membrane protein gene of paramyxovirus simian virus 5. Virology 176:234–243
    [Google Scholar]
  31. Shioda T., Iwaski K., Shibuta H. 1986; Determination of the complete nucleotide sequence of the Sendai virus genome RNA and the predicted amino acid sequences of the F, HN and L proteins. Nucleic Acids Research 14:1545–1563
    [Google Scholar]
  32. Sidhu M. S., Husar W., Cook S. D., Dowling P. C., Udem S. A. 1993; Canine distemper terminal and intergenic non-protein coding nucleotide sequences: completion of the entire CDV genome sequence. Virology 193:66–72
    [Google Scholar]
  33. Sidhu M. S., Chan J., Kaelin K., Spielhofer P., Radecke F., Schneider H., Masureker M., Dowling P. C., Billeter M. A., Udem S. A. 1995; Rescue of synthetic measles virus minireplicons:measles genomic termini direct efficient expression and propagation of a reporter gene. Virology 208:800–807
    [Google Scholar]
  34. Stewad M., Vipond I. B., Millar N. S., Emmerson P. T. 1993; RNA editing in Newcastle disease virus. Journal of General Virology 74:2539–2547
    [Google Scholar]
  35. Yusoff K., Millar N. S., Chambers P., Emmerson P. T. 1987; Nucleotide sequence analysis of the L gene of NDV : homologies with Sendai and vesicular stomatitis virus. Nucleic Acids Research 15:3961–3976
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-79-10-2419
Loading
/content/journal/jgv/10.1099/0022-1317-79-10-2419
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error