1887

Abstract

In a recent serological survey among 143 excaptive orang-utans two individuals were found that reacted positive in an ELISA detecting antibodies which cross-react with human T-lympho- tropic virus type I (HTLV-I) antigens. Infection of both animals with an HTLV-I or simian T-lympho- tropic virus (STLV)-like virus was confirmed by Western blot analysis. A third wild-caught animal, which was not part of the original serological survey, was also found to be infected with an HTLV- related virus in a diagnostic PCR assay and Western blot assay. Nucleotide sequence analysis of the 709 bp PCR fragment from the region of the HTLV/STLV genome confirmed infection of orangutans with an STLV similar to but clearly distinct from other Asian STLVs.

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/content/journal/jgv/10.1099/0022-1317-79-1-51
1998-01-01
2022-05-19
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References

  1. Digilio L., Giri A., Cho N., Slattery J., Markham P., Franchini G. 1997; The simian T-lymphotropic|leukemia virus from Pan paniscus belongs to the type 2 family and infects Asian macaques. Journal of Virology 71:3684–3692
    [Google Scholar]
  2. Gessain A., Gallo R. C., Franchini G. 1992; Low degree of human T-cell leukemia|lymphoma virus type I genetic drift in vivo as a means of monitoring viral transmission and movement of ancient human populations. Journal of Virology 66:2288–2295
    [Google Scholar]
  3. Gessain A., Boeri E., Yanagihara R., Gallo R. C., Franchini G. 1993; Complete nucleotide sequence of a highly divergent human T-cell leukemia (lymphotropic) virus type I (HTLV-I) variant from Melanesia: genetic and phylogenetic relationship to HTLV-I strains from other geographical regions. Journal of Virology 67:1015–1023
    [Google Scholar]
  4. Giri A., Markham P., Digilio L., Hurteau G., Gallo R. C., Franchini F. 1994; Isolation of a novel simian T-cell lymphotropic virus from Pan panicus that is distantly related to the human T-cell leukemia/lymphotropic virus types I and II. Journal of Virology 68:8392–8395
    [Google Scholar]
  5. Giri A., Slattery J. P., Heneine W., Gessain A., Rivadeneira E., Desrosiers R. C., Rosen L., Anthony R., Pamungkas J., Iskandriati D., Richards A. L., Herve V., McClure H., O’Brien S. J., Franchini G. 1997; The tax gene sequences form two divergent monophyletic lineages corresponding to types I and II of simian and human T-cell leukemia/lymphotropic viruses. Virology 231:96–104
    [Google Scholar]
  6. Ibrahim F., de The G., Gessain A. 1995; Isolation and characterization of a new simian T-cell leukemia virus type 1 from naturally infected Celebes macaques (Macaca tonkeana): complete nucleotide sequence and phylogenetic relationship with the Australo-Melanesian human T-cell leukemia virus type I. Journal of Virology 69:6980–6993
    [Google Scholar]
  7. Koralnik I. J., Boeri E., Saxinger W. C., Monico A. L., Fullen J., Gessain A., Guo H.-G., Gallo R. C., Markham P., Kalyanaraman V., Hirsch V., Allan J., Murthy K., Alford P., Slattery J. P., O’Brien S. J., Franchini G. 1994; Phylogenetic associations of human and simian T-cell leukemia/lymphotropic virus type I strains : evidence for interspecies transmission. Journal of Virology 68:2693–2707
    [Google Scholar]
  8. Kumar S., Tamura K., Nei M. 1993; MEGA: molecular evolutionary genetics analysis. version 1.0 Pennsylvania State University, University Park, Penn., USA:
    [Google Scholar]
  9. Liska V., Fultz P. N., Su L., Ruprecht R. M. 1997; Detection of simian T-cell leukemia virus type I infection in seronegative macaques. AIDS Research and Human Retroviruses 13:1147–1153
    [Google Scholar]
  10. Mahieux R., Ibrahim F., Mauclere P., Herve V., Michel P., Tekaia F., Chappey C., Garin B., van der Ryst E., Guillemain B., Ledru E., Delaporte E., de The G., Gessain A. 1997; Molecular epidemiology of 58 new African human T-cell leukemia virus type 1 (HTLV-1) strains: identification of a new and distinct HTLV-1 molecular subtype in Central Africa and in pygmies. Journal of Virology 71:1317–1333
    [Google Scholar]
  11. Maloney E. M., Biggar R. J., Neel J. V., Taylor M. E., Hahn B. H., Shaw G. M., Blattner W. A. 1992; Endemic human T cell lymphotropic virus type II infection among isolated Brazilian Amerindians. Journal of Infectious Diseases 166:100–107
    [Google Scholar]
  12. Saksena N. K., Herve V., Durand J. P., Leguenno B., Diop O. M., Digoutte J. P., Mathiot C., Muller M. C., Love J. L., Dube S., Sherman M. P., Benz P. M., Erensoy S., Galat-Luong A., Galat G., Paul B., Dube D. K., Barre-Sinoussi F., Poiesz B. 1994; Seroepidemiologic, molecular, and phylogenetic analyses of simian T-cell leukemia viruses (STLV-I) from various naturally infected monkey species from Central and Western Africa. Virology 198:297–310
    [Google Scholar]
  13. Shaw G. M., Gonda M. A., Flickinger G. H., Hahn B. H., Gallo R. C., Wong-Staal F. 1984; Genomes of evolutionarily divergent members of the human T-cell leukemia virus family (HTLV-I and HTLV-II) are highly conserved, especially in pX. Proceedings of the National Academy of Sciences, USA 81:4544–4548
    [Google Scholar]
  14. Sherman M. P., Saksena N. K., Dube D. K., Yanagihara R., Poiesz B. J. 1992; Evolutionary insights on the origin of human T-cell lymphoma/leukemia virus type I (HTLV-I) derived sequence analysis of a new HTLV-I variant from Papua New Guinea. Journal of Virology 66:2556–2563
    [Google Scholar]
  15. Song K.-J., Nerurkar V. R., Saitou N., Lazo A., Blakeslee J. R., Miyoshi I., Yanagihara R. 1994; Genetic analysis and molecular phylogeny of simian T-cell lymphotropic virus evolution in Asia and Africa. Virology 199:56–66
    [Google Scholar]
  16. Vandamme A.-M., Liu H.-F., van Brussel M., de Meurichy W., Desmyter J., Goubeau P. 1996; The presence of a divergent T-lymphotropic virus in a wild-caught pygmy chimpanzee (Pan paniscus) supports an African origin for the human T-lymphotropic/simian T-lymphotropic group ofviruses. Journal of General Virology 77:1089–1099
    [Google Scholar]
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