1887

Abstract

T lymphocytes obtained from pigs infected with a lethal dose of classical swine fever virus were analysed for phenotypic changes in the composition of T-cell subpopulations and for alterations in their immune responsiveness during the course of disease. Viral antigen detected in all subpopulations and the selective depletion of CD4 CD8 T cells showed that peripheral blood T lymphocytes were affected in the terminal stage (14–19 days postinfection) of classical swine fever whereas no implications for T lymphocytes were obvious during the first 10 days after infection. Furthermore, a depletion of CD1 CD4 CD8 ‘common thymocytes’ was characteristic for the infected animals. Studies on immune functions of peripheral T lymphocytes revealed an abrogation of cellular immune responses as early as 3–5 days after infection and thus before detection of viral antigens in these cells. The data suggest that early immunosuppression represents a crucial event for the manifestation of classical swine fever.

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1998-01-01
2022-05-19
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