1887

Abstract

Nucleotide sequences of the envelope protein genes of 19 geographically and temporally distinct dengue (DEN)-4 viruses were determined. Nucleic acid sequence comparison revealed that the identity among the DEN-4 viruses was greater than 92%. Similarity among deduced amino acids was between 96 and 100%; in most cases identical amino acid substitutions occurred among viruses from similar geographical regions. Alignment of nucleic acid sequences followed by parsimony analysis generated phylogenetic trees, which indicated that geographically independent evolution of DEN-4 viruses had occurred. DEN-4 viruses were separated into two genetically distinct subtypes (genotypes). Genotype-1 contains viruses from the Philippines, Thailand and Sri Lanka; genotype-2 consists of viruses from Indonesia, Tahiti, the Caribbean Islands (Puerto Rico, Dominica) and Central and South America.

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1997-09-01
2024-12-02
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References

  1. Blok J., Samuel S., Gibbs A. J., Vitarana U. T. 1989; Variation of the nucleotide and encoded amino acid sequences of the envelope gene from eight dengue-2 viruses. Archives of Virology 105:39–53
    [Google Scholar]
  2. Blok J., Gibbs A. J., McWilliam S. M., Vitarana U. T. 1991; NS1 gene sequences from eight dengue-2 viruses and their evolutionary relationships with other dengue-2 viruses. Archives of Virology 118:209–223
    [Google Scholar]
  3. Buonagurio D. H., Nakada S., Parvin J. D., Krystal M., Palese P., Fitch W. A. 1986; Evolution of human influenza A viruses over 50 years: rapid, uniform rate of change in Ns gene. Science 232:980–982
    [Google Scholar]
  4. Chungue E., Cassar O., Drouet M. T., Guzman M. G., Laille M., Rosen L., Deubel V. 1995; Molecular epidemiology of dengue-1 and dengue-4 viruses. Journal of General Virology 76:1877–1884
    [Google Scholar]
  5. Duebel V., Kinney R. M., Trent D. W. 1990; Nucleotide sequence and deduced amino acid sequence of the structural proteins of dengue type 2 virus, Jamaica genotype. Virology 155:365–377
    [Google Scholar]
  6. Gubler D. J. 1988; Dengue. In The Arboviruses: Epidemiology and Ecology 2 pp. 223–260 Monath T. P. Edited by Boca Raton, Fla: CRC Press;
    [Google Scholar]
  7. Gubler D. J. 1991; Dengue haemorrhagic fever: a global update. Virus Information Exchange Newsletter 8:2–3
    [Google Scholar]
  8. Gubler D. J., Trent D. W. 1994; Emergence of epidemic Dengue/ Dengue hemorrhagic fever as a public health problem in the Americas. Infectious Agents and Disease 2:383–393
    [Google Scholar]
  9. Halstead S. B. 1988; Pathogenesis of dengue: challenges to molecular biology. Science 239:476–481
    [Google Scholar]
  10. Henchal E. A., Putnak J. R. 1990; The dengue viruses. Clinical Microbiology Reviews 3:376–396
    [Google Scholar]
  11. Henchal E. A., Repik P. M., McCown J. M., Brandt W. E. 1986; Identification of an antigenic and genetic variant of dengue-4 virus from the Caribbean. American Journal of Tropical Medicine and Hygiene 35 (2):393–400
    [Google Scholar]
  12. Lanciotti R. S., Calisher C. H., Gubler D. J., Chang G.-J., Vorndam A. V. 1992; Rapid detection and typing of dengue viruses from clinical samples by using reverse transcriptase-polymerase chain reaction. Journal of Clinical Microbiology 30:545–551
    [Google Scholar]
  13. Lanciotti R. S., Lewis J. G., Gubler D. J., Trent D. W. 1994; Molecular evolution and epidemiology of dengue-3 viruses. Journal of General Virology 75:65–75
    [Google Scholar]
  14. Lewis J. G., Chang G.-J., Lanciotti R. S., Kinney R. K., Mayer L. W., Trent D. W. 1993; Phylogenetic relationships of dengue 2 viruses: correlation with epidemiology. Virology 197:216–224
    [Google Scholar]
  15. Mason P. W., McAda P. C., Mason T. W., Fournier M. J. 1987; Sequence of the dengue-1 virus genome in the region encoding the three structural proteins and the major nonstructural protein NS1. Virology 161:262–267
    [Google Scholar]
  16. Rey F. A., Heinz F. X., Mandl C., Kunz C., Harrison S. C. 1995; The envelope glycoprotein from tick-borne encephalitis virus at 2Å resolution. Nature 375:291–298
    [Google Scholar]
  17. Rico-Hesse R. 1990; Molecular evolution and distribution of dengue viruses type 1 and 2 in nature. Virology 174:479–493
    [Google Scholar]
  18. Rosen L. 1977; The emperor’s new clothes revisited, or reflections on the pathogenesis of dengue hemorrhagic fever. American Journal of Tropical Medicine and Hygiene 26:337–343
    [Google Scholar]
  19. Zanotto P. M., Gould E. A., Gao G. F., Harvey P. H., Holmes E. C. 1996; Population dynamics of flaviviruses revealed by molecular phylogenies. Proceedings of the National Academy of Sciences, USA 93:548–553
    [Google Scholar]
  20. Zhao B., Mackow E., Buckler-White A., Markoff L., Chanock R. M., Lai C., Makino Y. 1986; Cloning full length dengue type 4 viral DNA sequences : analysis of genes coding for structural proteins. Virology 155:77–88
    [Google Scholar]
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