1887

Abstract

Undifferentiated U937 cells were not susceptible to herpes simplex virus type 1 (HSV-1) infection, but after differentiation with phorbol 12-myristate 13- acetate an increase in the permissivity to the virus was observed accompanied by the production of significant levels of viral particles. High levels of nitric oxide (NO) were produced in differentiated U937 cells infected with HSV-1. This production was comparable to that observed after addition of the NO donor glycerine trinitrate. The levels of NO drastically decreased when the cells were incubated with -monomethyl arginine (-NMA), an inhibitor of NO synthase. Although similar levels of NO were sufficient to decrease susceptibility of U937 cells to other viruses, neither incubation with NO donors nor addition of -NMA altered the permissiveness to HSV-1 infection. Thus, these results suggest that NO does not interfere with the replication of HSV-1 in U937 cells.

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1997-08-01
2022-08-15
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References

  1. Akaike T., Noguchi Y., Sumiko I., Setoguchi K., Suga M., Zheng Y. M., Dietzschold B., Maeda H. 1996; Pathog enesis of influenza virus-induced pneumonia: involvement of both nitric oxide and oxygen radicals. Proceedings of the National Academy of Sciences, USA 93:2448–2453
    [Google Scholar]
  2. Albers I., Kirchner H., Domke-Opitz I. 1989; Resistance of human blood monocytes to infection with herpes simplex virus. Virology 169:466–469
    [Google Scholar]
  3. Braun R. W., Teute H. K., Kirchner H., Munk K. 1984; Replication of herpes simplex virus in human T lymphocytes: characterization of the viral target cell. Journal of Immunology 132:914–919
    [Google Scholar]
  4. Bukrinsky M. I., Nottet H. S., Schmidtmayerova H., Dubrovsky L., Flanagan C. R., Mullins M. E., Lipton S. A., Gendelman H. E. 1995; Regulat ion of nitric oxide synthase activity in human immunodeficiency virus type 1 (HIV-1)-infected monocytes: implications for HIV-associated neurological disease. Journal of Experimental Medicine 181:735–745
    [Google Scholar]
  5. Croen K. D. 1993; Evidence for an antiviral effect of nitric oxide: inhibition of herpes simplex virus type 1 replication. Journal of Clinical Investigation 91:2446–2452
    [Google Scholar]
  6. Guillemard E., Geniteau-Legendre M., Kergot R., Lemaire G., Petit J. F., Labarre C., Quero A. M. 1996; Activity of nitric oxidegenerating compounds against encephalomyocarditis virus. Antimicrobial Agents and Chemotherapy 40:1057–1059
    [Google Scholar]
  7. Halford W. P., Gebhardt B. M., Carr D. J. J. 1996; Mechanisms of herpes simplex virus type 1 reactivation. Journal of Virology 70:5051–5060
    [Google Scholar]
  8. Hammer S. M., Carney W. P., Iacoviello V. R., Lowe B., Hirsh M. S. 1982; Herpes simplex virus infection of human T-cell subpopulations. Infection and Immunity 38:795–797
    [Google Scholar]
  9. Hammer S. M., Gillis J. M., Groopman J. E., Rose R. M. 1986; In vitro modification of human immunodeficiency virus infection by granulocyte-macrophage colony-stimulating factor and gamma interferon. Proceedings ofthe NationalAcademy ofSciences, USA 83:8734–8738
    [Google Scholar]
  10. Karupiah G., Xie Q. W., Buller R. M. L., Nathan C., Duarte C., MacMicking J. D. 1993; Inhibition of viral replication by interferon-γ- induced nitric oxide synthase. Science 261:1445–1448
    [Google Scholar]
  11. Kreil T. R., Eibl M. M. 1996; Nitric oxide and viral infection: No antiviral activity against a flavivirus ‘in vitro’, and evidence for contribution to pathogenesis in experimental infection ‘in vivo’. Virology 219:304–306
    [Google Scholar]
  12. López-Guerrero J. A., Cabañas C., Bernabeu C., Fresno M., Alonso M. A. 1989; Poliovirus infection interferes with the phorbol ester-induced differentiation of the monocytic U937 cell line. Virus Research 14:65–72
    [Google Scholar]
  13. López-Guerrero J. A., Carrasco L., Martínez-Abarca F., Fresno M., Alonso M. A. 1990; Restriction of poliovirus RNA translation in a human monocytic cell line. European Journal ofBiochemistry 186:577–582
    [Google Scholar]
  14. López-Guerrero J. A., Rayet B., Tuynder M., Rommelaere J., Dinsart C. 1997; Constitutive activation of U937 promonocytic cell clones selected for their resistance to parvovirus H-1 infection. Blood 89:1642–1653
    [Google Scholar]
  15. Lowenstein C. J., Hill S. L., Lafond-Walker A., Wu J., Allen G., Landavere M., Rose N. R., Herskowitz A. 1996; Nitric oxide inhibits viral replication in murine myocarditis. Journal of Clinical Investigation 97:1837–1843
    [Google Scholar]
  16. Mannick J. B., Asano K., Izumi K., Kieff E., Stamler J. S. 1994; Nitric oxide produced by human B lymphocytes inhibits apoptosis and Epstein-Barr virus reactivation. Cell 79:1137–1146
    [Google Scholar]
  17. Mikami S., Kawashima S., Kanazawa K., Hirata K., Katayama Y., Hotta H., Hayashi Y., Ito H., Yokoyama M. 1996; Expression of nitric oxide synthase in a murine model of viral myocarditis induced by Coxsackievirus B3. Biochemical and Biophysical Research Communications 220:983–989
    [Google Scholar]
  18. Peiris J. S., Porterfield J. S. 1979; Antibody-mediated enhancement of flavivirus replication in macrophage-like cell lines. Nature 282:509–511
    [Google Scholar]
  19. Peluso R., Haase A., Stowring L., Edwards M., Ventura P. 1985; A Trojan Horse mechanism for the spread of visna virus in monocytes. Virology 147:231–236
    [Google Scholar]
  20. Stewart D. R., Anaraki F., Leary K. 1992; Analysis of the basis for persistence of herpes simplex virus type 1 in undifferentiated U937 cells. Viral Immunology 5:173–184
    [Google Scholar]
  21. Tenney D. J., Morahan P. S. 1987; Effects of differentiation of human macrophage-like U937 cells on intrinsic resistance to herpes simplex virus type 1. Journal of Immunology 139:3076–3083
    [Google Scholar]
  22. Tenney D. J., Morahan P. S. 1991; Differentiation of the U937 macrophage cell line removes an early block of HSV-1 infection. Viral Immunology 4:91–102
    [Google Scholar]
  23. Tucker P. C., Griffin D. E., Choi S., Bui N., Wesselingh S. 1996; Inhibition of nitric oxide synthesis increases mortality in Sindbis virus encephalitis. Journal of Virology 70:3972–3977
    [Google Scholar]
  24. Valentin A., Albert J., Fenyö E. M., Asjo B. 1990; HIV-1 infection of normal human macrophages cultures : implication for silent infection. Virology 177:790–794
    [Google Scholar]
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