1887

Abstract

The Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper we report the nucleotide sequences of S RNA of Candid #1 and its more virulent ancestors XJ#44 and XJ (prototype). Their relationship to Junin virus wild-type MC2 strain and other closely and distantly related arenaviruses was also examined. Comparisons of the nucleotide and amino acid sequences of N and GPC genes from Candid #1 and its progenitor strains revealed some changes that are unique to the vaccine strain. These changes could be provisionally associated with the attenuated phenotype.

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1997-07-01
2024-04-20
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References

  1. Auperin D., Romanowski V., Galinski M. S., Bishop D. H. L. 1984; Sequencing studies of Pichindé arenavirus S RNA indicate a novel coding strategy, an ambisense viral S RNA. Journal of Virology 52:897–904
    [Google Scholar]
  2. Bowen M. D., Peters C. J., Mills J. M., Nichols S. T. 1996a; Oliveros virus: a novel arenavirus from Argentina. Virology 217:362–366
    [Google Scholar]
  3. Bowen M. D., Peters C. J., Nichols S. T. 1996b; The phylogeny of New World (Tacaribe complex) arenaviruses. Virology 219:285–290
    [Google Scholar]
  4. Clegg J. C. S. 1993; Molecular phylogeny of the arenaviruses and guide to published sequence data. In The Arenaviridae pp 175–187 Salvato M. S. Edited by New York: Plenum Press;
    [Google Scholar]
  5. Davis N. L., Brown K. W., Greenwald G. F., Zajac A. J., Zacny V. L., Smith J. F., Johnston R. E. 1995; Attenuatedmutants ofVenezuelan equine encephalitis virus containing lethal mutations in the PE2 cleavage signal combined with a second-site suppressor mutation in E1. Virology 212:102–110
    [Google Scholar]
  6. Deshpande K. L., Fried V. A., Ando M., Webster R. G. 1987; Glycosylation affects cleavage of an H5N2 influenza virus hemagglutinin and regulates virulence. Proceedings of the National Academy of Sciences USA: 8436–40
    [Google Scholar]
  7. Endres M. J., Griot C., Gonzalez-Scarano F., Nathanson N. 1991; Neuroattenuation of an avirulent bunyavirus variant maps to the L RNA segment. Journal of Virology 65:5465–5470
    [Google Scholar]
  8. Franze-Fernandez M. T., Iapalucci S., Lopez N., Rossi C. 1993; Subgenomic RNAs of Tacaribe virus. In The Arenaviridae pp 113–132 Salvato M. S. Edited by New York: Plenum Press;
    [Google Scholar]
  9. Garcin D., Kolakofsky D. 1992; Tacaribe arenavirus RNA synthesis in vitro is primer dependent and suggests an unusual model for the initiation of genome replication. Virology 66:1370–1376
    [Google Scholar]
  10. Ghiringhelli P. D., Rivera-Pomar R. V., Lozano M. E., Grau O., Romanowski V. 1991; Molecular organization of Junin virus S RNA: complete nucleotide sequence, relationship with the other members of the Arenaviridae and unusual secondary structures. Journal of General Virology 72:2129–2141
    [Google Scholar]
  11. Ghiringhelli P. D., Albariño C. G., Piboul M., Romanowski V. 1996; The glycoprotein precursor gene of the attenuated Junin virus vaccine strain (Candid #1). American Journal of Tropical Medicine and Hygiene in press
    [Google Scholar]
  12. Griffiths C. M., Wilson S. M., Clegg J. C. S. 1992; Sequence of the nucleocapsid protein gene of Machupo virus: close relationship with another South American pathogenic arenavirus, Junin. Archives of Virology 124:371–377
    [Google Scholar]
  13. Maiztegui J. I., Feuillade M., Briggiler A. 1986; Progressive extension of the endemic area and changing incidence of AHF. Medical Microbiology and Immunology 175:73–78
    [Google Scholar]
  14. Maiztegui J. I., BarreraOro J. G., Feuillade M. R., Peters C. J., Vallejos D., McKee K. T. 1990; Inoculation of human volunteers with Candid #1, a live attenuated Junin virus vaccine candidate. Vlllth International Congress of Virology Berlin, Germany: Abstracts Book pp 111
    [Google Scholar]
  15. Parodi A. S., Greenway D. J., Rugiero H. R., Rivero E., Frigerio M. J., Mettler N. E., Garzon F., Boxaca M., Guerrero L. B., Nota N. R. 1958; Sobre la etiología del brote epidémico en Junín. Día Médico (Buenos Aires) 30:2300–2302
    [Google Scholar]
  16. Riviere Y., Ahmed R., Southern P. J., Buchmeier M. J., Oldstone M. B. A. 1985; Genetic mapping oflymphocytic choriomeningitis virus pathogenicity: virulence in guinea pigs is associated with the L RNA segment. Journal of Virology 55:704–709
    [Google Scholar]
  17. Romanowski V. 1993; Genetic organization of Junin virus, the etiological agent of argentine hemorrhagic fever. In The Arenaviridae pp 51–83 Salvato M. S. Edited by New York: Plenum Press;
    [Google Scholar]
  18. Salvato M., Shimomaye E. M. 1989; The completed sequence of lymphocytic choriomeningitis virus reveals a unique RNA structure and a gene for a zinc finger protein. Virology 173:1–10
    [Google Scholar]
  19. Salvato M., Shimomaye E., Oldstone M. B. A. 1989; The primary structure of the lymphocytic choriomeningitis virus L gene encodes a putative RNA polymerase. Virology 169:377–384
    [Google Scholar]
  20. Snyder M. H., Betts R. F., DeBorde D., Tierney E. L., Clements M. L., Herrington D., Sears S. D., Dolin R., Maassab H. F., Murphy B. R. 1988; Four viral genes independently contribute to attenuation of live influenza A/Ann Arbor/6/60 (H2N2) cold-adapted reassortant virus vaccines. Journal of Virology 62:488–495
    [Google Scholar]
  21. Tatem J. M., Weeks-Levy C., Georgiu A., DiMichele S. J., Gorgacz E. J., Racaniello V. R., Cano F. R., Mento S. J. 1992; A mutation present in the amino terminus of Sabin 3 poliovirus VP1 protein is attenuating. Journal of Virology 66:3194–3197
    [Google Scholar]
  22. Wilson S. M., Clegg J. C. S. 1991; Sequence analysis of the S RNA of the African arenavirus Mopeia : an unusual secondary structure feature in the intergenic region. Virology 180:543–552
    [Google Scholar]
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