@article{mbs:/content/journal/jgv/10.1099/0022-1317-78-5-1059, author = "Hatada, Eriko and Saito, Sakura and Okishio, Nobuyuki and Fukuda, Ryuji", title = "Binding of the influenza virus NS1 protein to model genome RNAs", journal= "Journal of General Virology", year = "1997", volume = "78", number = "5", pages = "1059-1063", doi = "https://doi.org/10.1099/0022-1317-78-5-1059", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-78-5-1059", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "We have previously shown that the influenza virus NS1 protein exhibits stable binding to a model mini vRNA which is stronger than its binding to dsRNA. In this study, we confirmed that the binding depended on a higher-order structure of the model RNA, probably the panhandle structure formed by pairing between the 5′ - and 3′ -terminal common sequences. The formation of the structure was enhanced by the NS1 protein itself. We propose that an A bulge in a stretch of double helix results in a binding site with greater affinity for the NS1 protein.", }