@article{mbs:/content/journal/jgv/10.1099/0022-1317-78-4-821, author = "Geretti, Anna-Maria and Hulskotte, Ellen G. J. and Dings, Marlinda E. M. and van Baalen, Carel A. and van Amerongen, Geert and Osterhaus, Albert D. M. E.", title = "CD8 cytotoxic T lymphocytes of a cynomolgus macaque infected with simian immunodeficiency virus (SIV) mac32H-J5 recognize a nine amino acid epitope in SIV Gag p26", journal= "Journal of General Virology", year = "1997", volume = "78", number = "4", pages = "821-824", doi = "https://doi.org/10.1099/0022-1317-78-4-821", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-78-4-821", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "A detailed analysis of simian immunodeficiency virus (SIV)-specific cytotoxic T lymphocyte (CTL) responses and the identification of the proteins and epitopes they target may improve the design of immunotherapeutic interventions and provide insights into AIDS pathogenesis. Here, we identified a new CTL epitope in the SIV Gag protein, recognized by CD8 and MHC class I-restricted CTL clones from a long-term asymptomatic cynomolgus macaque (Macaca fascicularis) infected with SIVmac32H-J5. Using overlapping synthetic peptides, the optimal minimal epitope was characterized as a nine amino acid peptide representing amino acids 242–250 of p26 (SVDEQIQWM). CTL recognition was shown to be abolished by amino acid substitutions observed within homologous human immunodeficiency virus (HIV)-1 and HIV-2 sequences.", }