1887

Abstract

is an endogenous defective murine leukaemia virus (MuLV) which expresses high levels of an envelope protein (Env) closely related to that of the ecotropic class of MuLVs. Mice bearing the natural gene or a transgenic version are resistant to infection by ecotropic MuLVs. mice secrete the surface peptide (SU) of the Env in their serum and this secreted Env can block infection of NIH3T3 cells. To study the secretion of Fv4, we metabolically labelled cells expressing Env or Env from infectious MuLVs and followed synthesis, glycosyl- ation, proteolytic processing and secretion of Env species. We found no difference in the kinetics of synthesis or processing of Env compared to the envelopes of infectious MuLVs, but Env associated more weakly with its transmembrane anchor and was shed from the surface of cells.

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1997-04-01
2022-08-11
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