The adenovirus 12 E1A proteins can bind directly to proteins of the p300 transcription co-activator family, including the CREB-binding protein CBP and p300.

References

1. Arany Z., Sellers W. R., Livingston D. M., Eckner R. 1994; ElA-associated p300 and CREB-associated CBP belong to a conserved family of coactivators. Cell 77:799–800
   [Google Scholar]
2. Arany Z., Newsome D., Oldread E., Livingston D. M., Eckner R. 1995; A family of transcriptional adaptor proteins targeted by the ElA oncoprotein. Nature 374:81–84
   [Google Scholar]
3. Arias J., Alberts A. S., Brindle P., Claret F. X., Smeal T., Karin M., Feramisco J., Montminy M. 1994; Activation of cAMP and mitogen responsive genes relies on a common nuclear factor. Nature 370:226–229
   [Google Scholar]
4. Boulukos K. E., Ziff E. B. 1993; Adenovirus 5 ElA proteins disrupt the neuronal phenotype and growth factor responsiveness of PC12 cells by a conserved region 1-dependent mechanism. Oncogene 8:237–248
   [Google Scholar]
5. Chrivia J. C., Kwok R. P. S., Lamb N., Hagiwara M., Montminy M. R., Goodman R. H. 1993; Phosphorylated CREB binds specifically to the nuclear protein CBP. Nature 365:855–859
   [Google Scholar]
6. Dorsman J. C., Hagmeyer B. M., Veenstra J., Elfferich P., Nabben N., Zantema A., van der Eb A. J. 1995; The N-terminal region of the adenovirus type 5 ElA proteins can repress expression of cellular genes via two distinct but overlapping domains. Journal of Virology 69:2962–2967
   [Google Scholar]
7. Eckner R., Ewen M. E., Newsome D., Gerdes M., de Caprio J. A., Bentley Lawrence J., Livingston D. M. 1994; Molecular cloning and functional analysis of the adenovirus ElA-associated 300-kD protein (p300) reveals a protein with properties of a transcriptional adaptor. Genes and Development 8:869–884
   [Google Scholar]
8. Graham F. L., van der Eb A. J. 1973; A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456–467
   [Google Scholar]
9. Guarente L. 1995; Transcriptional coactivators in yeast and beyond. Trends in Biochemical Science 20:5l7–52l
   [Google Scholar]
10. Hagmeyer B. M., Angel P., van Dam H. 1995; Modulation of AP-l/ATF transcription factor activity by the adenovirus -ElA oncogene products. BioEssays 17:621–629
    [Google Scholar]
11. Harlow E., Lane D. 1988 Antibodies: A Laboratory Manual Cold Spring Harbor, NY: Cold Spring Harbor Laboratory;
    [Google Scholar]
12. Horikoshi N., Maguire K., Kralli A., Maldonado E., Reinberg D., Weinmann R. 1991; Direct interaction between adenovirus ElA protein and the TATA box binding transcription factor IID. Proceedings of the National Academy of Sciences, USA 88:5124–5l28
    [Google Scholar]
13. Jelinek T., Pereira D. S., Graham F. L. 1994; Tumorigenicity of adenovirus-transformed rodent cells is influenced by at least two regions of adenovirus type l2 early region lA. Journal of Virology 68:888–896
    [Google Scholar]
14. Kaelin W. G., Krek W., Sellers W. R., de Caprio J. A., Ajchenbaum F., Fuchs C. S., Chittenden T., Li Y., Farnham P. J., Blanar M. A., Livingston D. M., Flemington E. K. 1992; Expression cloning of a cDNA encoding a retinoblastoma-binding protein with E2F-like properties. Cell 70:35l–364
    [Google Scholar]
15. Kwok R. P. S., Lundblad J. R., Chrivia J. C., Richards J. P., Bächinger H. P., Brennan R. G., Roberts S. G. E., Green M. R., Goodman R. H. 1994; Nuclear protein CBP is a coactivator for the transcription factor CREB. Nature 370:223–226
    [Google Scholar]
16. Lundblad J. R., Kwok R. P. S., Laurance M. E., Harter M. L., Goodman R. H. 1995; Adenoviral ElA-associated protein p300 as a functional homologue of the transcriptional co-activator CBP. Nature 374:85–88
    [Google Scholar]
17. Meijer I., van Dam H., Boot A. J. M., Bos J. L., Zantema A., van der Eb A. J. 1991; Co-regulated expression ofjunB and MHC class I genes in adenovirus-transformed cells. Oncogene 6:911–9l6
    [Google Scholar]
18. Moran E. 1994; Mammalian cell growth controls reflected through protein interactions with the adenovirus ElA gene products. Seminars in Virology 5:327–340
    [Google Scholar]
19. Peeper D. S., Zantema A. 1993; Adenovirus-ElA proteins transform cells by sequestering regulatory proteins. Molecular Biology Reports 17:197–207
    [Google Scholar]
20. Peeper D. S., Zantema A., Dowdy S. F., van der Eb A. J. 1992; Expression, purification, and functional characterization of adenovirus 5 and l2 ElA proteins produced in insect cells. Virology 190:733–745
    [Google Scholar]
21. Petrij F., Giles R. H., Dauwerse H. G., Saris J. J., Hennekam R. C., Masuno M., Tommerup N., van Ommen G. J., Goodman R. H., Peters D., Breuning M. H. 1995; Rubinstein-Taybi syndrome is caused by mutations in the transcriptional co-activator CBP. Nature 376:348–35l
    [Google Scholar]
22. Smith D. B., Johnson K. S. 1988; Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S- transferase. Gene 67:31–40
    [Google Scholar]
23. van Dam H., Offringa R., Meijer I., Stein B., Smits A. M., Herrlich P., Bos J. L., van der Eb A. J. 1990; Differential effects of the adenovirus ElA oncogene on members of the AP-l transcription factor family. Molecular and Cellular Biology 10:5857–5864
    [Google Scholar]
24. Wang H. -G. H., Yaciuk P., Ricciardi R. P., Green M., Yokoyama K., Moran E. 1993; The ElA products of oncogenic adenovirus serotype l2 include amino-terminally modified forms able to bind the retinoblastoma protein but not p300. Journal of Virology 67:4804–48l3
    [Google Scholar]