RT Journal Article SR Electronic(1) A1 Phelan, Anne A1 Clements, J. BarklieYR 1997 T1 Herpes simplex virus type 1 immediate early protein IE63 shuttles between nuclear compartments and the cytoplasm JF Journal of General Virology, VO 78 IS 12 SP 3327 OP 3331 DO https://doi.org/10.1099/0022-1317-78-12-3327 PB Microbiology Society, SN 1465-2099, AB Herpes simplex virus type 1 (HSV-1) immediate early protein IE63, an essential nuclear protein, is pleiotropic in function and, at the post-transcriptional level, inhibits RNA splicing, interacts with cellular splicing small nuclear ribonucleoprotein particles (snRNPs), binds RNA and prevents the nucleocytoplasmic transport of intron-containing mRNAs. Here it is reported that IE63 is a nucleo-cytoplasmic shuttle protein able to travel from snRNP-and RNA-rich nuclear foci to the cytoplasm, where it accumulates during actinomycin D treatment. This newly identified property suggests that IE63 facilitates nuclear export of HSV-1 transcripts, in addition to retaining intron-containing transcripts in the nucleus. The mechanism by which IE63 controls RNA export has yet to be defined., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-78-12-3327