RT Journal Article SR Electronic(1) A1 Haagmans, Bart L A1 Teerds, Katja J A1 van den Eijnden-van Raaij, Adriana J. M A1 Horzinek, Marian C A1 Schijns, Virgil E. C. JYR 1997 T1 Transforming growth factor beta production during rat cytomegalovirus infection. JF Journal of General Virology, VO 78 IS 1 SP 205 OP 213 DO https://doi.org/10.1099/0022-1317-78-1-205 PB Microbiology Society, SN 1465-2099, AB We analysed the production of transforming growth factor β (TGF-β) during a cytomegalovirus (CMV) infection in a rat model system. Splenocytes from immunocompetent rats infected with rat CMV (RCMV) released increased amounts of TGF-β 1. TGF- β production was also evident in RCMV-infected radiation-immunosuppressed rats; their sera inhibited the interleukin 2-induced proliferation of T cells, which could be restored by anti-TGF-β anti bodies. In addition, TGF-β production could be visualized immunohistologically in the lungs, spleen, liver and bone marrow of radiation-immunosuppressed infected rats. The virus directly induced this cytokine since TGF-β was produced upon RCMV infection in vitro. The induction of TGF-β production may contribute to immunosuppression during CMV infection., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-78-1-205