1887

Abstract

We analysed the production of transforming growth factor (TGF-) during a cytomegalovirus (CMV) infection in a rat model system. Splenocytes from immunocompetent rats infected with rat CMV (RCMV) released increased amounts of TGF- . TGF- production was also evident in RCMV-infected radiation-immunosuppressed rats; their sera inhibited the interleukin 2-induced proliferation of T cells, which could restored by anti-TGF- anti bodies. In addition, TGF- production could be visualized immunohistologically in the lungs, spleen, liver and bone marrow of radiation-immunosuppressed infected rats. The virus directly induced this cytokine since TGF- was produced upon RCMV infection . The induction of TGF- production may contribute to immunosuppression during CMV infection.

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1997-01-01
2024-06-20
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