1887

Abstract

Sequence variations are seen in the JC virus promoter/enhancer in virus taken from progressive multifocal leukoencephalopathy (PML) brains and it has been hypothesized that the variations arise in the host at some point in the development of PML. These rearrangements may be adaptations for enhanced growth in glial cells; if so, transcription or replication levels should differ between archetypal and rearranged PML-type promoters. The archetype and four PML-type promoters were analysed in human glial cells for early and late transcriptional activity in the absence or presence of virus T antigen, and for DNA replication. CAT reporter expression differed within a fivefold range and the archetype was intermediate in strength to the PML-type regulatory regions. The archetype differed from rearranged promoters in that the late promoter was less responsive to T antigen and the shift from early to late activity with T antigen was less pronounced. All five regulatory regions demonstrated similar levels of DNA replicating activity. Rearrangement of the archetype was not required for activity in glial cells, but the potential for differences in the regulation of the late capsid genes was found.

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1997-01-01
2024-04-20
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References

  1. Ahmed S., Rappaport J., Tada H., Kerr D., Khalili K. 1990; A nuclear protein derived from brain cells stimulates transcription of the human neurotropic virus promoter, JCVE, in vitro. Journal of Biological Chemistry 265:13899–13905
    [Google Scholar]
  2. Amemiya K., Traub R., Durham L., Major E. O. 1989; Interaction of a nuclear factor-1-like protein with the regulatory region of the human polyomavirus JC virus. Journal of Biological Chemistry 264:7025–7032
    [Google Scholar]
  3. Arthur R. R., Shah K. V. 1989; Occurrence and significance of papovaviruses BK and JC in the urine. Progress in Medical Virology 36:42–61
    [Google Scholar]
  4. Atwood W. J., Amemiya K., Traub R., Harms J., Major E. O. 1992; Interaction of the human polyomavirus, JCV, with human B-lymphocytes. Virology 190:716–723
    [Google Scholar]
  5. Atwood W. J., Wang L., Durham L. C., Amemiya K., Traub R. G., Major E. O. 1995; Evaluation of the role of cytokine activation in the multiplication of JC virus (JCV) in human fetal glial cells. Journal of Neurovirology 1:40–49
    [Google Scholar]
  6. Ault G. S., Stoner G. L. 1992; Two major types of JC virus defined in progressive multifocal leukoencephalopathy brain by early and late coding region DNA sequences. Journal of General Virology 73:2669–2678
    [Google Scholar]
  7. Ault G. S., Stoner G. L. 1993; Human polyomavirus JC promoter/ enhancer rearrangement patterns from progressive multifocal leuko-encephalopathy brain are unique derivatives of a single archetypal structure. Journal of General Virology 74:1499–1507
    [Google Scholar]
  8. Ault G. S., Stoner G. L. 1994; Brain and kidney of progressive multifocal leukoencephalopathy patients contain identical rearrangements of the JC virus promoter/enhancer. Journal of Medical Virology 44:298–304
    [Google Scholar]
  9. Cassill J. A., Subramani S. 1989; A naturally occurring deletion in the enhancer repeats of the human papovavirus BK optimizes early enhancer function at the expense of late promoter activity. Virology 170:296–298
    [Google Scholar]
  10. Chowdhury M., Kundu M., Khalili K. 1993; GA/GC-rich sequence confers Tat responsiveness to human neurotropic virus promoter, JCVL, in cells derived from central nervous system. Oncogene 8:887–892
    [Google Scholar]
  11. Coleman D. V., Wolfendale M. R., Daniel R. A., Dhanjal N. K., Gardner S. D., Gibson P. E., Field A. M. 1980; A prospective study of human polyomavirus infection in pregnancy. Journal of Infectious Diseases 142:1–8
    [Google Scholar]
  12. Daniel A. M., Swenson J. J., Mayreddy R. P. R., Khalili K., Frisque R. J. 1996; Sequences within the early and late promoters of archetype JC virus restrict viral DNA replication and infectivity. Virology 216:90–101
    [Google Scholar]
  13. Daniel A. M., Frisque R. J. 1993; Transcription initiation sites of prototype and variant JC virus early and late messenger RNAs. Virology 194:97–109
    [Google Scholar]
  14. Feigenbaum L., Khalili K., Major E. O., Khoury G. 1987; Regulation ofthe host range ofhuman papovavirus JCV. Proceedings ofthe National Academy of Sciences, USA 84:3695–3698
    [Google Scholar]
  15. Flaegstad T., Sundsfjord A., Arthur R. R., Pedersen M., Traavik T., Subramani S. 1991; Amplification and sequencing of the control regions of BK and JC virus from human urine by polymerase chain reaction. Virology 180:553–560
    [Google Scholar]
  16. Frisque R. J., Bream G. L., Cannella M. T. 1984; Human polyomavirus JC virus genome. Journal of Virology 51:458–469
    [Google Scholar]
  17. Frisque R. J., White F. A. III 1992; The molecular biology of JC virus, causative agent of progressive multifocal leukoencephalopathy. In Neurovirology - Pathogenesis of Viral CNS Infections pp. 25–158 Roos R. P., Totowa N. J. Edited by New York: Humana;
    [Google Scholar]
  18. Heilbronn R., Albrecht I., Stephan S., Burkle A., zur Hausen H. 1993; Human cytomegalovirus induces JC virus DNA replication in human fibroblasts. Proceedings ofthe National Academy of Sciences, USA 90:11406–11410
    [Google Scholar]
  19. Henson J., Saffer J., Furneaux H. 1992; The transcription factor Sp1 binds to the JC virus promoter and is selectively expressed in glial cells in human brain. Annals of Neurology 32:72–77
    [Google Scholar]
  20. Hirt B. 1967; Selective extraction of polyoma DNA from infected mouse cell cultures. Journal of Molecular Biology 26:365–369
    [Google Scholar]
  21. Hogan T. F., Padgett B. L., Walker D. L. 1991; Human polyoma- viruses. In Textbook of Human Virology pp. 970–1000 Belshe R. B. Edited by St Louis: Mosby;
    [Google Scholar]
  22. Houff S. A., Major E. O., Katz D. A., Kufta C. V., Sever J. L., Pittaluga S., Roberts J. R., Gitt J., Saini N., Lux W. 1988; Involvement of JC virus-infected mononuclear cells from the bone marrow and spleen in the pathogenesis of progressive multifocal leukoencephalopathy. New England Journal of Medicine 318:301–305
    [Google Scholar]
  23. Iida T., Kitamura T., Guo J., Taguchi F., Aso Y., Nagashima K., Yogo Y. 1993; Origin of JC polyomavirus variants associated with progressive multifocal leukoencephalopathy. Proceedings of the National Academy of Sciences, USA 90:5062–5065
    [Google Scholar]
  24. Kenney S., Natarajan V., Strike D., Khoury G., Salzman N. P. 1984; JC virus enhancer-promoter active in human brain cells. Science 226:1337–1339
    [Google Scholar]
  25. Kenney S., Natarajan V., Salzman N. P. 1986; Mapping 5′ termini of JC virus late RNA. Journal of Virology 58:216–219
    [Google Scholar]
  26. Kitamura T., Aso Y., Kuniyoshi N., Hara K., Yogo Y. 1990; High incidence of urinary JC virus excretion in nonimmunosuppressed older patients. Journal of Infectious Diseases 161:1128–1133
    [Google Scholar]
  27. Kitamura T., Yogo Y., Kunitake T., Suzuki K., Tajima A., Kawabe K. 1994; Effect of immunosuppression on the urinary excretion of BK and JC polyomaviruses in renal allograft recipients. International Journal of Urology 1:28–32
    [Google Scholar]
  28. Krebs C. J., McAvoy M. T., Kumar G. 1995; The JC virus minimal core promoter is glial cell specific in vivo. Journal of Virology 69:2434–2442
    [Google Scholar]
  29. Lashgari M. S., Tada H., Amini S., Khalili K. 1989; Regulation of JCVL promoter function: transactivation of JCVL promoter by JCV and SV40 early proteins. Virology 170:292–295
    [Google Scholar]
  30. Loeber G., Dörries K. 1988; DNA rearrangements in organ-specific variants of polyomavirus JC strain GS. Journal of Virology 62:1730–1735
    [Google Scholar]
  31. Lynch K. J., Frisque R. J. 1990; Identification of critical elements within the JC virus DNA replication origin. Journal of Virology 64:5812–5822
    [Google Scholar]
  32. Major E. O., Ault G. S. 1995; Progressive multifocal leuko- encephalopathy: clinical and laboratory observations on a viral induced demyelinating disease in the immunodeficient patient. Current Opinion in Neurology 8:184–190
    [Google Scholar]
  33. Markowitz R. B., Eaton B. A., Kubik M. F., Latorra D., McGregor J. A., Dynan W. S. 1991; BK virus and JC virus shed during pregnancy have predominantly archetypal regulatory regions. Journal of Virology 65:4515–4519
    [Google Scholar]
  34. Markowitz R. B., Thompson H. C., Mueller J. F., Cohen J. A., Dynan W. S. 1993; Incidence of BK virus and JC virus viruria in human immunodeficiency virus-infected and -uninfected subjects. Journal of Infectious Diseases 167:13–20
    [Google Scholar]
  35. Nakshatri H., Pater A., Pater M. M. 1990; Activity and enhancer binding factors for JC virus regulatory elements in differentiating embryonal carcinoma cells. Virology 177:784–789
    [Google Scholar]
  36. Padgett B. L., Walker D. L. 1973; Prevalence of antibodies in human sera against JC virus, an isolate of progressive multifocal leukoencephalopathy. Journal of Infectious Diseases 127:467–470
    [Google Scholar]
  37. Raj G. V., Khalili K. 1995; Transcriptional regulation: lessons from the human neurotropic polyomavirus, JCV. Virology 213:283–291
    [Google Scholar]
  38. Renner K., Leger H., Wegner M. 1994; The POU domain protein Tst-1 and papovaviral large tumor antigen function synergistically to stimulate glia-specific gene expression of JC virus. Proceedings of the National Academy of Sciences, USA 91:6433–6437
    [Google Scholar]
  39. Sock E., Wegner M., Grummt F. 1991; DNA replication of human polyomavirus JC is stimulated by NF-I in vivo. Virology 182:298–308
    [Google Scholar]
  40. Sock E., Wegner M., Fortunato E. A., Grummt F. 1993; Large T-antigen and sequences within the regulatory region of JC virus both contribute to the features of JC virus DNA replication. Virology 197:537–548
    [Google Scholar]
  41. Sock E., Renner K., Feist D., Leger H., Wegner M. 1996; Functional comparison of PML-type and archetype strains of JC virus. Journal of Virology 70:1512–1520
    [Google Scholar]
  42. Tada H., Lashgari M. S., Rappaport J., Khalili K. 1989; Cell type- specific expression of JC virus early promoter is determined by positive and negative regulation. Journal of Virology 63:463–466
    [Google Scholar]
  43. Tada H., Rappaport J., Lashgari M. S., Amini S., Wong-Staal F., Khalili K. 1990; Trans-activation of the JC virus late promoter by the tat protein of type 1 human immunodeficiency virus in glial cells. Proceedings of the National Academy of Sciences, USA 87:3479–3483
    [Google Scholar]
  44. Tamura T., Inoue T., Nagata K., Mikoshiba K. 1988; Enhancer of human polyoma JC virus contains nuclear factor I-binding sequences; analysis using mouse brain nuclear extracts. Biochemical and Biophysical Research Communications 157:419–425
    [Google Scholar]
  45. Tominaga T., Yogo Y., Kitamura T., Aso Y. 1992; Persistence of archetypal JC virus DNA in normal renal tissue derived from tumorbearing patients. Virology 186:736–741
    [Google Scholar]
  46. Tornatore C., Berger J. R., Houff S. A., Curfman B., Meyers K., Winfield D., Major E. O. 1992; Detection of JC virus DNA in peripheral lymphocytes from patients with and without progressive multifocal leukoencephalopathy. Annals of Neurology 31:454–462
    [Google Scholar]
  47. Tornatore C., Amemiya K., Atwood W. J., Conant K., Major E. O. 1994; JC virus : current concepts and controversies in the molecular virology and pathogenesis of progressive multifocal leukoencephalo- pathy. Reviews in Medical Virology 4:197–219
    [Google Scholar]
  48. Wegner M., Drolet D. W., Rosenfeld M. G. 1993; Regulation of JC virus by the POU-domain transcription factor Tst-1 : implications for progressive multifocal leukoencephalopathy. Proceedings of the National Academy of Sciences, USA 90:4743–4747
    [Google Scholar]
  49. Yogo Y., Kitamura T., Sugimoto C., Ueki T., Aso Y., Hara K., Taguchi F. 1990; Isolation of a possible archetypal JC virus DNA sequence from nonimmunocompromised individuals. Journal of Virology 64:3139–3143
    [Google Scholar]
  50. Yogo Y., Guo J., Iida T., Satoh K.-I., Taguchi F., Takahashi H., Hall W. W., Nagashima K. 1994; Occurrence of multiple JC virus variants with distinctive regulatory sequences in the brain of a single patient with progressive multifocal leukoencephalopathy. Virus Genes 8:99–105
    [Google Scholar]
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