1887

Abstract

Cells infected with two closely related isolates of bovine viral diarrhoea virus (BVDV), one cytopathic (CP) and one non-cytopathic (NCP), were examined for signs of apoptosis. The results from labelling DNA using terminal transferase and biotinylated dUTP and by observing oligonucleosomal-sized DNA fragmentation indicated that the CP strain of BVDV induced apoptosis in cell culture but the NCP strain did not. Induction of apoptosis correlated with infected cells undergoing apoptosis rather than interactions between infected and uninfected cells and the induction of apoptosis by CP BVDV was a dominant trait in cells co-infected with both types of virus.

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1996-08-01
2022-01-16
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References

  1. Brownlie J. 1991; The pathway for bovine virus diarrhoea virus biotypes in the pathogenesis of disease. Archives of Virology Supplementum 3:79–96
    [Google Scholar]
  2. Clem R. J., Feehheimer M., Miller L. K. 1991; Prevention of apoptosis by a baculovirus gene during infection of insect cells. Science 254:1388–1390
    [Google Scholar]
  3. Collett M. S., Larson R., Gold C., Strick D., Anderson D. K., Purchio A. F. 1988; Molecular cloning and nucleotide sequence of the pestivirus bovine viral diarrhea virus. Virology 165:191–199
    [Google Scholar]
  4. De Moerlooze L., Lecomte C., Brown-Shimmer S., Schmetz D., Guiot C., Vandenbergh D., Allaer D., Rossius M., Chappuis G., Dina D., Renard A., Martial J. A. 1993; Nucleotide sequence of the bovine viral diarrhoea virus Osloss strain: comparison with related viruses and identification of specific DNA probes in the 5′ untranslated region. Journal of General Virology 74:1433–1438
    [Google Scholar]
  5. Deng T., Brock K. V. 1992; Molecular cloning and nucleotide sequence of a pestivirus genome, noncytopathic bovine viral diarrhea virus strain SD-1. Virology 191:867–879
    [Google Scholar]
  6. Donis R. O., Dubovi E. J. 1987; Differences in virus-induced polypeptides in cells infected by cytopathic and noncytopathic biotypes of bovine virus diarrhea-mucosal disease virus. Virology 158:168–173
    [Google Scholar]
  7. Gavrieli Y., Sherman Y., Ben-Sasson S. A. 1992; Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation. Journal of Cell Biology 119:493–501
    [Google Scholar]
  8. Gregory C. D., Dive C., Henderson S., Smith C. A., Williams G. T., Gordon I., Rickinson A. B. 1991; Activation of Epstein–Barr virus latent genes protects human B-cells from death by apoptosis. Nature 349:612–614
    [Google Scholar]
  9. Laurent-Crawford A. G., Krust B., Muller S., Riviere Y., Rey-Cuille M.-A., Bechet J.-M., Montagnier L., Hovanessian A. G. 1991; The cytopathic effect of HIV is associated with apoptosis. Virology 185:829–839
    [Google Scholar]
  10. Lazebnik Y. A., Kaufman S. H., Desnoyers S., Poirier G. G., Earnshaw W. C. 1995; Cleavage of poly(ADP-Robose) polymerase by a proteinase with properties like ICE. Nature 371:346–347
    [Google Scholar]
  11. Levine B., Huang Q., Isaacs J. T., Reed J. C., Griffin D. E., Hardwick J. M. 1993; Conversion of lytic to persistent alphavirus infection by the bcl-2 cellular oncogene. Nature 361:739–742
    [Google Scholar]
  12. Meyers G., Tautz N., Stark R., Brownlie J., Dubovi E. J., Collett M. S., Thiel H. -J. 1992; Rearrangement of viral sequences in cytopathogenic pestiviruses. Virology 191:368–386
    [Google Scholar]
  13. Miura M., Zhu H., Rotelio R., Hartwieg E. A., Yuan J. -Y. 1993; Induction of apoptosis in fibroblasts by IL-l-beta-converting enzyme, a mammalian homolog of the C. elegans cell-death gene ced-3. Cell 75:653–660
    [Google Scholar]
  14. Pocock D. H., Howard C. J., Clarke M. C., Brownlie J. 1987; Variation in the intracellular polypeptide profiles from different isolates of BVDV. Archives of Virology 94:43–53
    [Google Scholar]
  15. Rao L., Debbas M., Sabbatini P., Hockenbery D., Korsmeyer S., White E. 1992; The adenovirus Ela proteins induce apoptosis, which is inhibited by the Elb 19-kda and bcl-2 proteins. Proceedings of the National Academy of Sciences, USA 89:7742–7746
    [Google Scholar]
  16. Takizawa T., Matsukawa S., Higuchi Y., Nakamura S., Nakanishi Y., Fukuda R. 1993; Induction of programmed cell death (apoptosis) by influenza vims infection in tissue culture cells. Journal of General Virology 74:2347–2355
    [Google Scholar]
  17. Tamura J. K., Warrener P., Collett M. S. 1993; RNA-stimulated NTPase activity associated with the p80 protein of the pestivirus bovine viral diarrhea vims. Virology 193:1–10
    [Google Scholar]
  18. Tautz N., Thiel H. -J., Dubovi E. J., Meyers G. 1994; Pathogenesis of mucosal disease: a cytopathogenic pestivirus generated by an internal deletion. Journal of Virology 68:289–329
    [Google Scholar]
  19. Warrener P., Collett M. S. 1995; Pestivims NS3 (p80) protein possesses RNA helicase activity. Journal of Virology 69:1720–1726
    [Google Scholar]
  20. Wiskerchen M., Collett M. S. 1991; Pestivims gene expression: protein p80 of bovine viral diarrhea vims is a proteinase involved in polyprotein processing. Virology 184:341–350
    [Google Scholar]
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