RT Journal Article SR Electronic(1) A1 Rozinov, Michael N. A1 Fields, Bernard N.YR 1996 T1 Interference of reovirus strains occurs between the stages of uncoating and dsRNA accumulation JF Journal of General Virology, VO 77 IS 7 SP 1425 OP 1429 DO https://doi.org/10.1099/0022-1317-77-7-1425 PB Microbiology Society, SN 1465-2099, AB Interference of wild-type reovirus growth by some temperature-sensitive (ts) mutant viruses under non-permissive conditions or by other wild-type isolates has been demonstrated; however, the stage of the virus replication cycle at which interference occurs has not been defined. Examination of the time-course of the yields of T1 Lang (T1L) dsRNA in the progeny of mixed infections of T1L with T3 Dearing (T3D) or with a panel of T3D ts mutants at a non-permissive temperature revealed that interference takes place by 8–10 h post-infection and occurs prior to or at the same time as accumulation of reovirus dsRNA. Taken together with our previous results, these data indicate that interference occurs during a window between virus uncoating and synthesis of dsRNA in the reovirus replication cycle, probably at the stage of assembly of primary reovirus particles., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-77-7-1425