1887

Abstract

Introduction. The genus , family , is the largest genus of plant viruses with 180 members or possible members (Brunt, 1992). Potyviruses are flexuous filamentous particles which contain a single-stranded RNA genome of positive polarity possessing a covalently linked 5′-terminal viral protein (VPg) and a 3′-terminal poly(A) tail (reviewed in Riechmann , 1992). They are transmitted from plant to plant by aphids in a non-persistent manner, and this process is dependent on the presence of two virus-encoded proteins (reviewed in Pirone, 1991). One of these, the helper component-proteinase (HC-Pro) has attracted renewed attention during the last few years due to its multifunctionality and to it being implicated in different steps of the potyvirus life cycle. The properties, as well as the established and postulated functions of this protein, are reviewed.

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1996-07-01
2024-11-05
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References

  1. Ammar E. D., Jarlfors U., Pirone T. P. 1994; Association of potyvirus helper component protein with virions and the cuticle lining the maxillary food canal and foregut of an aphid vector. Phytopathology 84:1054–1060
    [Google Scholar]
  2. Atreya C. D., Pirone T. P. 1993; Mutational analysis of the helper component-proteinase gene of a potyvirus: effects of amino acid substitutions, deletions, and gene replacement on virulence and aphid transmissibility. Proceedings of the National Academy of Sciences, USA 90:11919–11923
    [Google Scholar]
  3. Atreya C. D., Raccah B., Pirone T. P. 1990; A point mutation in the coat protein abolishes aphid transmissibility of a potyvirus. Virology 178:161–165
    [Google Scholar]
  4. Atreya P. L., Atreya C. D., Pirone T. P. 1991; Amino acid substitutions in the coat protein result in loss of insect transmissibility of a plant virus. Proceedings of the National Academy of Sciences, USA 88:7887–7891
    [Google Scholar]
  5. Atreya C. D., Atreya P. L., Thombury D. W., Pirone T. P. 1992; Site-directed mutations in the potyvirus HC-PRO gene affect helper component activity, virus accumulation, and symptom expression in infected tobacco plants. Virology 191:106–111
    [Google Scholar]
  6. Berger P. H., Pirone T. P. 1986; The effect of helper component on the uptake and localization of potyviruses in Myzus persicae. Virology 153:256–261
    [Google Scholar]
  7. Brunt A. A. 1992; The general properties of potyviruses. Archives of Virology Supplementum 53–16
    [Google Scholar]
  8. Canto T., Lopez-Moya J. J., Serra-Yoldi M. T., Diaz-Ruiz J. R., Lopez-Abella D. 1995; Different helper component mutations associated with lack of aphid transmissibility in two isolates of potato virus. Phytopathology 85:1519–1524
    [Google Scholar]
  9. Carrington J. C., Herndon K. L. 1992; Characterization of the potyviral HC-Pro autoproteolytic cleavage site. Virology 187:308–315
    [Google Scholar]
  10. Carrington J. C., Cary S. M., Parks T. D., Dougherty W. G. 1989a; A second proteinase encoded by a plant potyvirus genome. EMBO Journal 8:365–370
    [Google Scholar]
  11. Carrington J. C., Freed D. D., Sanders T. C. 1989b; Autocatalytic processing of the potyvirus helper component proteinase in Escherichia coli and in vitro. Journal of Virology 63:4459–4463
    [Google Scholar]
  12. Carrington J. C., Freed D. D., Oh C.-S. 1990; Expression of potyviral polyproteins in transgenic plants reveals three proteolytic activities required for complete processing. EMBO Journal 9:1347–1353
    [Google Scholar]
  13. Choi G. H., Pawlyk D. M., Nuss D. L. 1991; The autocatalytic protease p29 encoded by a hypovirulence-associated virus of the chestnut blight fungus resembles the poty virus-encoded protease HC-Pro. Virology 183:747–752
    [Google Scholar]
  14. Cronin S., Verchot J., Haldeman-Cahill R., Schaad M. C., Carrington J. C. 1995; Long-distance movement factor: a transport function of the potyvirus helper component proteinase. Plant Cell 7:549–559
    [Google Scholar]
  15. De Mejia M. V. G., Hiebert E., Purcifull D. E., Thombury D. W., Pirone T. P. 1985; Identification of potyviral amorphous inclusion protein as a nonstructural, virus-specific protein related to helper component. Virology 142:34–43
    [Google Scholar]
  16. Dolja V. V., Herndon K. L., Pirone T. P., Carrington J. C. 1993; Spontaneous mutagenesis of a plant potyvirus genome after insertion of a foreign gene. Journal of Virology 67:5968–5975
    [Google Scholar]
  17. Dolja V. V., Haldeman R., Robertson N. L., Dougherty W. G., Carrington J. C. 1994; Distinct functions of capsid protein in assembly and movement of tobacco etch potyvirus in plants. EMBO Journal 13:1482–1491
    [Google Scholar]
  18. Dolja V. V., Haldeman-Cahill R., Montgomery A. E., Vandenbosch K. A., Carrington J. C. 1995; Capsid protein determinants involved in cell-to-cell and long distance movement of tobacco etch potyvirus. Virology 206:1007–1016
    [Google Scholar]
  19. Dornier L. L., Franklin K. M., Shahaduddin M., Hellmann G. M., Overmeyer J. H., Hiremath S. T., Siaw M. F. E., Lomonossoff G. P., Shaw J. G., Rhoads R. E. 1986; The nucleotide sequence of tobacco vein mottling virus RNA. Nucleic Acids Research 14:5417–5430
    [Google Scholar]
  20. Gal-On A., Antignus Y., Rosner A., Raccah B. 1992; A zucchini yellow mosaic virus coat protein gene mutation restores aphid transmissibility but has no effect on multiplication. Journal of General Virology 73:2183–2187
    [Google Scholar]
  21. Govier D. A., Kassanis B. 1974a; Evidence that a component other than the virus particle is needed for aphid transmission of potato virus Y. Virology 57:285–286
    [Google Scholar]
  22. Govier D. A., Kassanis B. 1974b; A virus-induced component of plant sap needed when aphids acquire potato virus Y from purified preparations. Virology 61:420–426
    [Google Scholar]
  23. Govier D. A., Kassanis B., Pirone T. P. 1977; Partial purification and characterization of the potato virus Y helper component. Virology 78:306–314
    [Google Scholar]
  24. Granier F., Durand-Tardif M., Casse-Delbart F., Lecoq H., Robaglia C. 1993; Mutations in zucchini yellow mosaic virus helper component protein associated with loss of aphid transmissibility. Journal of General Virology 74:2737–2742
    [Google Scholar]
  25. Grumet R., Bada R., Hammar S. 1992; Analysis of the zucchini yellow mosaic virus (ZYMV) potyviral helper component, possible identification of an aphid-interaction domain. Phytopathology. 82:1176
    [Google Scholar]
  26. Harrison B. D., Robinson D. J. 1988; Molecular variation in vector-borne plant viruses: epidemiological significance. Philosophical Transactions of the Royal Society of London Series B 321:447–462
    [Google Scholar]
  27. Hellmann G. M., Thombury D. W., Hiebert E., Shaw J. G., Pirone T. P., Rhoads R. E. 1983; Cell-free translation of tobacco vein mottling virus RNA. II. Immunoprecipitation of products by antisera to cylindrical inclusion, nuclear inclusion, and helper component proteins. Virology 124:434–444
    [Google Scholar]
  28. Hellmann G. M., Hiremath S. T., Shaw J. G., Rhoads R. E. 1986; Cistron mapping of tobacco vein mottling virus. Virology 151:159–171
    [Google Scholar]
  29. Huet H., Gal-On A., Meir E., Lecoq H., Raccah B. 1994; Mutations in the helper component protease gene of zucchini yellow mosaic virus affect its ability to mediate aphid transmissibility. Journal of General Virology 75:1407–1414
    [Google Scholar]
  30. Kassanis B. 1961; The transmission of potato aucuba mosaic virus by aphids from plants also infected by potato viruses A or Y. Virology 13:93–97
    [Google Scholar]
  31. Kassanis B., Govier D. A. 1971a; New evidence on the mechanism of aphid transmission of potato C and potato aucuba mosaic viruses. Journal of General Virology 10:99–101
    [Google Scholar]
  32. Kassanis B., Govier D. A. 1971b; The role of the helper virus in aphid transmission of potato aucuba mosaic virus and potato virus C. Journal of General Virology 13:221–228
    [Google Scholar]
  33. Kasschau K. D., Carrington J. C. 1995; Requirement for HC-Pro processing during genome amplification of tobacco etch potyvirus. Virology 209:268–273
    [Google Scholar]
  34. Klein P. G., Klein R. R., Rodn’guez-Cerezo E., Hunt A. G., Shaw J. G. 1994; Mutational analysis of the tobacco vein mottling virus genome. Virology 204:759–769
    [Google Scholar]
  35. Lecoq H., Pitrat M. 1985; Specificity of the helper-component-mediated aphid transmission of three potyviruses infecting muskmelon. Phytopathology 75:890–893
    [Google Scholar]
  36. Lecoq H., Bourdin D., Raccah B., Hiebert E., Purcifull D. E. 1991; Characterization of a zucchini yellow mosaic virus isolate with a deficient helper component. Phytopathology 81:1087–1091
    [Google Scholar]
  37. Legavre T., Maia I. G., Casse-Delbart F., Bernardi F., Robaglia C. 1996; Switches in the mode of transmission select for or against a poorly aphid-transmissible strain of potato virus Y with reduced helpercomponent and virus accumulation. Journal of General Virology 77:1343–1347
    [Google Scholar]
  38. Maia I. G., Bernardi F. 1996; Nucleic acid-binding properties of a bacterially expressed potato virus Y helper component-proteinase. Journal of General Virology 77:869–877
    [Google Scholar]
  39. Oh C.-S., Carrington J. C. 1989; Identification of essential residues in potyvirus proteinase HC-Pro by site-directed mutagenesis. Virology 173:692–699
    [Google Scholar]
  40. Pirone T. P. 1981; Efficiency and selectivity of the helper-component-mediated aphid transmission of purified potyviruses. Phytopathology 71:922–924
    [Google Scholar]
  41. Pirone T. P. 1991; Viral genes and gene products that determine insect transmissibility. Seminars in Virology 2:81–87
    [Google Scholar]
  42. Raccah B., Pirone T. P. 1984; Characteristics of factors affecting helper-component mediated aphid transmission of a potyvirus. Phytopathology 74:305–308
    [Google Scholar]
  43. Riechmann J. L., Lain S., Garcia J. A. 1992; Highlights and prospects of potyvirus molecular biology. Journal of General Virology 73:1–16
    [Google Scholar]
  44. Robaglia C., Durand-Tardif M., Tronchet M., Boudazin G., Astier-Manifacier S., Casse-Delbart F. 1989; Nucleotide sequence of potato virus Y (N strain) genomic RNA. Journal of General Virology 70:935–947
    [Google Scholar]
  45. Sako N., Ogata K. 1981; Different helper factors associated with aphid transmission of some potyviruses. Virology 112:762–765
    [Google Scholar]
  46. Salomon R., Bernardi F. 1995; Inhibition of viral aphid transmission by the N-terminus of the maize dwarf mosaic virus coat protein. Virology 213:676–679
    [Google Scholar]
  47. Thombury D. W., Pirone T. P. 1983; Helper components of two potyviruses are serologically distinct. Virology 125:487–490
    [Google Scholar]
  48. Thombury D. W., Hellmann G. M., Rhoads R. E., Pirone T. P. 1985; Purification and characterization of potyvirus helper component. Virology 144:260–267
    [Google Scholar]
  49. Thombury D. W., Patterson C. A., Dessens J. T., Pirone T. P. 1990; Comparative sequence of the helper component (HC) region of potato virus Y and a HC-defective strain, potato virus C. Virology 178:573–578
    [Google Scholar]
  50. Thombury D. W., Van Den Heuvel J. F. J. M., Lesnaw J. A., Pirone T. P. 1993; Expression of potyvirus proteins in insect cells infected with a recombinant baculovirus. Journal of General Virology 74:2731–2735
    [Google Scholar]
  51. Wang R. Y., Ammar E. D., Thombury D. W., Lopez-Moya J. J., Pirone T. P. 1996; Loss of potyvirus transmissibility and helpercomponent activity correlates with non-retention of virions in aphid stylets. Journal of General Virology 77:861–867
    [Google Scholar]
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