Previously, we have shown that E5a can induce ex pression of the c- gene in human papillomavirus (HPV)-11 E5a transformed NIH 3T3 cells and human epidermal keratinocytes. In this study, we investigated the relationship between expression of the E5a gene and c- in pathologically confirmed condylomata specimens using mRNA hybridization . The c- RNA concentration was significantly higher in condylomata specimens with E5a mRNA expression than in specimens without E5a mRNA expression, or in normal cervical specimens. The cells with c- expression were located predominantly in the basal and parabasal cell layers. These layers were also the primary location of E5a-expressing cells. This is the first demonstration of a strong correlation (74%) between expression of the E5a and c- genes in condylomata specimens. This correlation might reflect regulation by HPV-11 E5a of c- gene expression in condyloma.


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