1887

Abstract

Following orf virus reinfection in sheep, CD8 T cells were recruited to the lesion site in the skin during the period of viral replication and appeared in increased numbers in afferent lymph draining the infection site. A proportion of the CD8 T cells were activated, particularly in the skin, as determined by their expression of the cytolytic cell-associated serine protease, BLT-esterase. This was a useful marker for activated cytolytic cells as there was a good correlation between afferent lymph CD8 T cell-mediated lysis of autologous orf virus-infected skin cells and their expression of BLT-esterase . The majority of the cells that expressed BLT-esterase in the skin and lymph were CD8 T cells and cytolysis was predominately by the MHC class I antigen presentation pathway. The conclusion is that orf virus reinfection is characterized by limited viral replication and stimulation of an activated CTL response in the skin.

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/content/journal/jgv/10.1099/0022-1317-77-5-953
1996-05-01
2019-11-22
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http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-77-5-953
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