1887

Abstract

DBA/2 mice treated with anti-Mac1 monoclonal antibody (MAb) failed to develop encephalomyocarditis virus (EMCV)-induced diabetes and myocarditis. Virus concentrations and the number of viral RNA-positive cells in the pancreas and heart were significantly reduced in mice treated with anti-Mac1 MAb. Mac1-positive macrophages seem to be involved in EMCV-induced disease and to affect the replication of EMCV in target organs.

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1996-04-01
2024-06-20
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References

  1. Babu P. G., Huber S. A., Craighead J. E. 1986; Contrasting features of T-lymphocyte-mediated diabetes in encephalomyocarditis virus-infected BALB/cBy and BALB/cCum mice. American Journal of Pathology 124:193–198
    [Google Scholar]
  2. Baek H. S., Yoon J. W. 1990; Direct involvement of macrophages in destruction of β-cells leading to development of diabetes in virus-infected mice. Diabetes 40:1586–1597
    [Google Scholar]
  3. Barger M. T., Craighead J. E. 1991; Immunomodulation of encephalomyocarditis virus-induced disease in A/J mice. Journal of Virology 65:2676–2681
    [Google Scholar]
  4. Bergelson J. M., Shepley M. P., Chan B. M., Hemler M. E., Finberg R. W. 1992; Identification of the integrin VLA-2 as receptor for echovirus 1. Science 225:1718–1720
    [Google Scholar]
  5. Craighead J. E. 1966; Pathogenicity of the M and E variants of encephalomyocarditis (EMC) virus. I. Myocardiotropic and neurotropic properties. American Journal of Pathology 48:333–345
    [Google Scholar]
  6. Craighead J. E., McLean M. F. 1968; Diabetes mellitus. Induction in mice by encephalomyocarditis virus. Science 162:913–914
    [Google Scholar]
  7. Hirasawa K., Takeda M., Matsuzaki H., Doi K. 1991; Encephalomyocarditis (EMC) virus-induced orchitis in Syrian hamsters. International Journal of Experimental Pathology 72:617–622
    [Google Scholar]
  8. Hirasawa K., Takeda M., Itagaki S., Doi K. 1996; Involvement of macrophages in the development of encephalomyocarditis virus (EMC)-induced diabetes in mice. Experimental Animals 45:77–80
    [Google Scholar]
  9. Hirota S., Ito A., Morii E., Wanaka A., Tohyama M., Kitamura Y., Nomura S. 1992; Localization of mRNA for c-kit receptor and its ligand in the brain of adult rats: an analysis using in situ hybridization. Molecular Brain Research 15:47–54
    [Google Scholar]
  10. Huber S. A. 1994; VCAM-1 is a receptor for encephalomyocarditis virus on murine vascular endothelial cells. Journal of Virology 68:3453–3458
    [Google Scholar]
  11. Matsuzaki H., Doi K., Mitsuoka T., Tsuda T., Onodera T. 1989; Experimental encephalomyocarditis virus infection in Mongolian gerbils (Meriones unguiculatus). Veterinary Pathology 26:11–17
    [Google Scholar]
  12. Prober J. S., Cotran R. S. 1991; What can be learned from the expression of endothelial adhesion molecules in tissues?. Laboratory Investigation 64:301–305
    [Google Scholar]
  13. Racaniello V. R. 1990; Cell receptors for picornaviruses. Current Topics in Microbiology and Immunology 161:1–22
    [Google Scholar]
  14. Sriram R. L., Topham D. J., Huang S. K., Rodriguez M. 1989; Treatment of encephalomyocarditis virus induced demyelination with monoclonal anti-T-cell antibodies. Journal of Virology 63:4242–4248
    [Google Scholar]
  15. Thornhill M. H., Wellicome S. M., Mahiouz D. L., Lanchbury J. S., Kyan-Aung U., Haskard D. O. 1991; Tumor necrosis factor combines with IL-4 or IFN-y to selectively enhance endothelial cell adhesiveness for T cells. Journal of Immunology 146:592–598
    [Google Scholar]
  16. Tomassini J. E., Graham D., Dewitt C. M., Lineberger J. A., Rodkey J. A., Colonno R. J. 1989; cDNA cloning reveals the major group rhinovirus receptor on HeLa cells is intercellular adhesion molecule 1. Proceedings of the National Academy of Sciences, USA 86:4907–4911
    [Google Scholar]
  17. Yamada T., Matsumori A., Sasayama S. 1993; Therapeutic effect of anti-tumor necrosis factor-α antibody on the murine model of viral myocarditis induced by encephalomyocarditis virus. Circulation 89:846–851
    [Google Scholar]
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