RT Journal Article SR Electronic(1) A1 FoĆ -Tomasi, Laura A1 Fiorilli, Maria Pia A1 Avitabile, Elisa A1 Campadelli-Fiume, GabriellaYR 1996 T1 Identification of an 85 kDa phosphoprotein as an immunodominant protein specific for human herpesvirus 7-infected cells JF Journal of General Virology, VO 77 IS 3 SP 511 OP 518 DO https://doi.org/10.1099/0022-1317-77-3-511 PB Microbiology Society, SN 1465-2099, AB The reactivity of human cord blood sera was directed most frequently in Western blot assays to a protein with an apparent molecular mass of 85 kDa that belongs to the p85 complex, a family of antigenically related proteins identified previously in our laboratory with the aid of two MAbs. We show that the 85 kDa protein is phosphorylated. As antibodies present in the human sera were directed in part to proteins carrying cross-reactive epitopes between human herpesvirus 6 (HHV-6) and 7 (HHV-7), it is remarkable that reactivity to the 85 kDa phosphoprotein was maintained after preabsorption of the sera with HHV-6 antigen, but abolished after preabsorption with HHV-7 antigen. Therefore, the 85 kDa phosphoprotein may be considered a major determinant of the human immune response to HHV-7, discriminating HHV-6 from HHV-7 infection., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-77-3-511