@article{mbs:/content/journal/jgv/10.1099/0022-1317-77-3-413, author = "Sapats, S. I. and Ashton, F. and Wright, P. J. and Ignjatovic, J.", title = "Sequence analysis of the S1 glycoprotein of infectious bronchitis viruses: identification of a novel genotypic group in Australia", journal= "Journal of General Virology", year = "1996", volume = "77", number = "3", pages = "413-418", doi = "https://doi.org/10.1099/0022-1317-77-3-413", url = "https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-77-3-413", publisher = "Microbiology Society", issn = "1465-2099", type = "Journal Article", abstract = "Sequencing of the S1 genes of nine Australian strains of infectious bronchitis virus (IBV) identified two genotypically distinct groups of strains. The strains Vic S, V5/90, N1/62, N3/62, N9/74 and N2/75 comprised group I, sharing 80.7–98.3% identity in their deduced amino acid sequences. All group I strains were able to replicate in the trachea and kidney but only four strains, Vic S, N1/62, N9/74 and N2/75, were nephropathogenic, the latter three causing mortalities ranging from 32 to 96%. Group II contained strains N1/88, Q3/88 and V18/91 which only replicated in the trachea, inducing no mortalities. These viruses showed 72.3–92.8% amino acid identity to each other and only 53.8–61.7% identity to viruses of the first group. They were also distinct from the Massachusetts 41 and D1466 strains (47.5–55.7% amino acid identity). Thus N1/88, Q3/88 and V18/91 form a new group of viruses which are genotypically distinct from all previously characterized IBV strains. No definite correlations were established between the S1 amino acid sequences and the nephropathogenicity of strains.", }