1887

Abstract

Ross River virus (RRV) is the aetiological agent of epidemic polyarthritis (EPA) a predominantly rheumatic disease afflicting up to 5000 Australians annually. We show here for the first time that macrophages can be productively infected by RRV. Subneutralizing titres of anti-RRV IgG (but not IgM) also showed classical antibody-dependent enhancement (ADE) of RRV infection in macrophage and monocyte cell lines. No correlation between development of EPA and the preexistence of ADE titres was apparent, nor could sera raised against a related arbovirus, Barmah Forest, enhance RRV infection. Tumour necrosis factor-α, implicated in the immunopathogenesis of rheumatoid arthritis, was not secreted by RRV-infected monocytes or macrophages. Macrophage cell lines infected with RRV were, however, capable of producing virus for over 50 days. RRV-induced arthritis may therefore be due to the persistent productive infection of macrophages, perhaps established by a brief period of ADE early in infection.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-77-3-407
1996-03-01
2023-02-01
Loading full text...

Full text loading...

/deliver/fulltext/jgv/77/3/JV0770030407.html?itemId=/content/journal/jgv/10.1099/0022-1317-77-3-407&mimeType=html&fmt=ahah

References

  1. Aaskov J. G., Doherty R. L. 1994; Arboviral zoonosis of Australasia. In Handbook of Zoonoses 2nd edn. pp 289–304 Edited by Beran G. W. CRC Press:Boca Raton.:
    [Google Scholar]
  2. Cardosa M. J., Porterfield J. S., Gordon S. 1983; Complement receptor mediates enhanced Flavivirus replication in macrophages. Journal of Experimental Medicine 158:258–263
    [Google Scholar]
  3. Chang D. H., Shaio M. F. 1994; Production of interleukin-1 (IL-1) and IL-1 inhibitor by human monocytes exposed to dengue virus. Journal of Infectious Diseases 170:811–817
    [Google Scholar]
  4. Elliott M. J., Maini R. N., Feldmann M., Long-Fox A., Charles P., Katsikis P., Brennan F. M., Walker J., Bijl H., Ghrayeb J., Woody J. N. 1993; Treatment of rheumatoid arthritis with chimeric monoclonal antibodies to tumor necrosis factor α. Arthritis and Rheumatism 36:1681–1690
    [Google Scholar]
  5. Fraser J. R. E. 1986; Epidemic polyarthritis and Ross River virus disease. Clinics in Rheumatic Diseases 12:369–388
    [Google Scholar]
  6. Hogan M. M., Vogel S. N. 1994; Measurement of tumour necrosis factor α and β. In Current Protocols in Immunology vol 1 pp 6.10.1–6.10.5 Edited by Coligan J. E., Kruisbeek A. M., Margulies D. H., Shevach E. M., Strober W. E. New York: John Wiley & Sons;
    [Google Scholar]
  7. Kanno H., Wolfinbarger J. B., Bloom M. E. 1993; Aleutian mink disease parvovirus infection of mink macrophages and human macrophage cell line U937: Demonstration of antibody-dependent enhancement of infection. Journal of Virology 67:7017–7024
    [Google Scholar]
  8. Keat A. C. S., Hughes R. 1993; Infectious agents in reactive arthritis. Current Opinion in Rheumatology 5:414–419
    [Google Scholar]
  9. Kurane L., Kontny U., Janus J., Ennis F. A. 1990; Dengue-2 virus infection of human mononuclear cell lines and establishment of persistent infections. Archives of Virology 110:91–101
    [Google Scholar]
  10. Levine B., Hardwick J. M., Griffin D. E. 1994; Persistence of alphaviruses in vertebrate hosts. Trends in Microbiology 2:25–28
    [Google Scholar]
  11. May C., Carter S. D., Bell S. C., Bennett D. 1994; Immune responses to canine distemper virus in joint diseases in dogs. British Journal of Rheumatism 33:27–31
    [Google Scholar]
  12. Morens D. M., Halstead S. B. 1990; Measurement of antibody-dependent infection enhancement of four dengue virus serotypes by monoclonal and polyclonal antibodies. Journal of General Virology 71:2909–2914
    [Google Scholar]
  13. Narayan O., Zink M. C., Gorrell M., Mcentee M., Sharma D., Adams R. 1992; Lentivirus induced arthritis in animals. Journal of Rheumatology 19:25–32
    [Google Scholar]
  14. Porterfield J. S. 1986; Antibody-dependent enhancement of viral infectivity. Advances in Virus Research 31:335–355
    [Google Scholar]
  15. Seay A. R., Griffin D. E., Johnson R. T. 1981; Experimental viral polymyositis: age dependency and immune responses to Ross River virus infection in mice. Neurology 31:656–661
    [Google Scholar]
  16. Simon A. K., Seipelt E., Sieper J. 1994; Divergent T-cell cytokine patterns in inflammatory arthritis. Proceedings of the National Academy of Sciences, USA 91:8562–8566
    [Google Scholar]
  17. Thomsom S. A., Khanna R., Gardner J., Burrows S. B., Coupar B., Moss D., Suhrbier A. 1995; Minimal epitopes expressed in a recombinant polyepitope protein are processed and presented to CD8+ cytotoxic T cells: implication to vaccine design. Proceedings of the National Academy of Sciences, USA 92:5845–5849
    [Google Scholar]
  18. White J. M. 1993; Integrins as virus receptors. Current Biology 3:596–599
    [Google Scholar]
  19. Ziegler-Heitbrock H. W. L., Thiel E., Fuetterer A., Herzog V., Wirtz A., Riethmueller U. 1988; Establishment of a human cell line (Mono Mac 6) with characteristics of mature monocytes. International Journal of Cancer 41:456–461
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-77-3-407
Loading
/content/journal/jgv/10.1099/0022-1317-77-3-407
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error