1887

Abstract

A Vero E6 cell culture isolate of Tula virus (TUL), a hantavirus first detected in European common voles ( and ) by RT-PCR was obtained after initial passaging of TUL-infected vole lung samples in laboratory-colonized . TUL was defined as a classical serotype by a cross-focus-reduction neutralization test (FRNT) and was also shown to be distinct from other hantaviruses by haemagglutination inhibition assay. The sequences of S, M and partial L genome segments of the isolate were determined: the S segment was 99.9% identical to the original rodent-derived sequence. Serological evidence for a previous TUL infection was obtained from the serum of a blood donor living near a TUL focus in Moravia, Czech Republic, showing at least a 16-fold higher FRNT titre to TUL as compared to Puumala or other hantaviruses.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-77-12-3063
1996-12-01
2024-03-28
Loading full text...

Full text loading...

/deliver/fulltext/jgv/77/12/JV0770123063.html?itemId=/content/journal/jgv/10.1099/0022-1317-77-12-3063&mimeType=html&fmt=ahah

References

  1. Antic D., Yong Kang C., Spik K., Schmaljohn C., Vapalahti O., Vaheri A. 1992; Comparison of the deduced gene products of the L, M and S genome segments of hantaviruses. Virus Research 24:35–46
    [Google Scholar]
  2. Avsic-Zupanc T., Toney A., Anderson K., Chu Y.-K., Schmaljohn C. 1995; Genetic and antigenic properties of Dobrava virus; a unique member of the Hantavirus genus, family Bunyaviridae . Journal of General Virology 76:2801–2808
    [Google Scholar]
  3. Brummer-Korvenkontio M., Vaheri A., Hovi T., Von Bonsdorff C. H., Vuorimies J., Manni T., Penttinen K., OkerBlom N., Lahdevirta J. 1980; Nephropathia epidemica: detection of antigen in bank voles and serologic diagnosis of human infections. Journal of Infectious Diseases 141:131–134
    [Google Scholar]
  4. Brummer-Korvenkontio M., Manni T., Ukkonen S., Vaheri A. 1986; Detection of hemagglutination-inhibiting antibodies in patients with nephropathia epidemica and Korean hemorrhagic fever by using Puumala virus cell culture antigen. Journal of Infectious Diseases 153:997–998
    [Google Scholar]
  5. Chu Y. K., Rossi C., Leduc J. W., Lee H. W., Schmaljohn C. S., Dalrymple J. M. 1994; Serological relationships among viruses in the Hantavirus genus, family Bunyaviridae . Virology 198:196–204
    [Google Scholar]
  6. Chu Y. K., Jennings G., Schmaljohn A., Elgh F., Hjelle B., Lee H. W., Jenison S., Ksiazek T., Peters C. J., Rollin P., Schmaljohn C. S. 1995; Cross-neutralization of hantaviruses with immune sera from experimentally infected animals and from hemorrhagic fever with renal syndrome and hantavirus pulmonary syndrome patients. Journal of Infectious Diseases 172:1581–1584
    [Google Scholar]
  7. Hörling J., Chizhikov V., Lundkvist A., Jonsson M., Ivanov L., Dekonenko A., Niklasson B., Dzagurova T., Peters C. J., Tkachenko E., Nichol S. 1996; Khabarovsk virus: a phylogenetically and serologically distinct Hantavirus isolated from Microtus fortis trapped in far-east Russia. Journal of General Virology 77:687–694
    [Google Scholar]
  8. Khan A. S., Ksiazek T. G., Peters C. J. 1996; Hantavirus pulmonary syndrome. Lancet 347:739–741
    [Google Scholar]
  9. Lee H. W., Lee P. W. 1978; Isolation of the etiologic agent of Korean hemorrhagic fever. Journal of Infectious Diseases 137:289–308
    [Google Scholar]
  10. Lee P. W., Amyx H. L., Gajdusek D. C., Yanagihara R. T., Goldgaber D., Gibbs C. J. J. 1982; New hemorrhagic fever with renal syndrome- related virus in indigenous wild rodents in the United States. Lancet ii:1405
    [Google Scholar]
  11. Lundkvist Å, Niklasson B. 1994; Haemorrhagic fever with renal syndrome and other hantavirus infections. Reviews in Medical Virology 4:177–184
    [Google Scholar]
  12. Lundkvist Å., Kallio-Kokko H., Brus Sjolander K., Lankinen H., Niklasson B., Vaheri A., Vapalahti O. 1996a; Characterization of Puumala virus nucleocapsid protein: identification of B-cell epitopes and domains involved in protective immunity. Virology 216:397–406
    [Google Scholar]
  13. Lundkvist Å., Vapalahti O., Plyusnin A., Brus Sjolander K., Niklasson B., Vaheri A. 1996b; Tula hantavirus nucleocapsid protein: characterization of antigenic determinants defined by monoclonal antibodies raised against baculovirus-expressed protein. Virus Research (in press)
    [Google Scholar]
  14. Nichol S. T., Spiropoulou C. F., Morzunov S., Rollin P. E., Ksiazek T. G., Feldmann H., Sanchez A., Childs J., Zaki S., Peters C. J. 1993; Genetic identification of a novel hantavirus associated with an outbreak of acute respiratory illness in the southwestern United States. Science 262:914–917
    [Google Scholar]
  15. Niethammer J., Krapp F. 1982; Microtus aroalis (Pallas, 1779)-Feldmaus. In Handbuch der Sdugetiere Europas pp 284–318 Edited by Niethammer J., Krapp F. Wiesbaden: Akademische Verlagsgesellschaft;
    [Google Scholar]
  16. Niklasson B., Jonsson M., Lundkvist Å., Hörling J., Tkachenko E. 1991; Comparison of European isolates of viruses causing hemorrhagic fever with renal syndrome by a neutralization test. American Journal of Tropical Medicine and Hygiene 45:660–665
    [Google Scholar]
  17. Plyusnin A., Vapalahti O., Lankinen H., Lehväslaiho H., Apekina N., Myasnikov Y., Kallio-Kokko H., Henttonen H., Lundkvist Å., Brummer-Korvenkontio M., Gavrilovskaya I., Vaheri A. 1994; Tula virus: a newly detected hantavirus carried by European common voles. Journal of Virology 68:7833–7839
    [Google Scholar]
  18. Plyusnin A., Cheng Y., Vapalahti O., Pejoch M., Unar J., Jelinkova Z., Lehvaslaiho H., Lundkvist A., Vaheri A. 1995; Genetic variation in Tula hantaviruses: sequence analysis of the S and M segments of strains from Central Europe. Virus Research 39:237–250
    [Google Scholar]
  19. Plyusnin A., Lehväslaiho H., Vaheri A. 1996a; Unique and conserved features of Tula hantavirus M gene encoding envelope glycoproteins G1 and G2. Virus Genes 12:259–266
    [Google Scholar]
  20. Plyusnin A., Vapalahti O., Vaheri A. 1996b; Hantaviruses: genome structure, expression and evolution. Journal of General Virology 77:2677–2687
    [Google Scholar]
  21. Schmaljohn C. S. 1996; Molecular biology of Hantaviruses. In The Bunyaviridae pp 63–90 Edited by Elliott R. M. New York & London: Plenum Press;
    [Google Scholar]
  22. Schmaljohn A., Li D., Negley D. L., Bressler D. S., Turell M. J., Korch G. W., Ascher M. S., Schmaljohn C. S. 1995; Isolation and initial characterization of a newfound hantavirus from California. Virology 206:963–972
    [Google Scholar]
  23. Sibold C., Sparr S., Schulz A., Labuda M., Kozuch O., Lysy J., Kruger D. H., Meisel D. H. 1995; Genetic characterisation of a new hantavirus detected in Microtus arvalis from Slovakia. Virus Genes 10:276–281
    [Google Scholar]
  24. Vapalahti O., Kallio-Kokko H., Närvänen A., Julkunen I., Lundkvist A., Plyusnin A., Lehvaslaiho H., Brummer-Korvenkontio M., Vaheri A., Lankinen H. 1995; Human B-cell epitopes of Puumala virus nucleocapsid protein, the major antigen in early serological response. Journal of Medical Virology 46:293–303
    [Google Scholar]
  25. Yanagihara R., Gajdusek D. C., Gibbs C. J. 1984; Serologic evidence for infection in mammalogists. New England Journal of Medicine 310:1325–1326
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-77-12-3063
Loading
/content/journal/jgv/10.1099/0022-1317-77-12-3063
Loading

Data & Media loading...

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error