RT Journal Article SR Electronic(1) A1 McKeating, Jane A.YR 1996 T1 Biological consequences of human immunodeficiency virus type 1 envelope polymorphism: does variation matter? JF Journal of General Virology, VO 77 IS 12 SP 2905 OP 2919 DO https://doi.org/10.1099/0022-1317-77-12-2905 PB Microbiology Society, SN 1465-2099, AB Human immunodeficiency virus type 1 (HIV-1) establishes persistent infections in humans, in most cases leading to the development of AIDS. HIV-1 infects CD4+ lymphocytes, monocytes and dendritic cells in the peripheral blood and lymphoid organs, and microglia in the central nervous system (Gartner et al., 1986; Koenig et al., 1986; Pope et al., 1994). This virus tropism correlates with expression of the cell surface antigen CD4, which has been shown to be the principal receptor interacting with the virus surface glycoprotein, gp 120 (Dalgleish et al., 1984; Klatzmann et al., 1984). However, cell surface expression of CD4 alone is not sufficient to confer susceptibility to infection by HIV-1. Recently, several members of the chemokine receptor family of G-protein coupled seven transmembrane spanning proteins were identified as additional coreceptors (Alkhatib et al., 1996; Choe et al., 1996; Deng et al., 1996; Doranz et al., 1996; Dragic et al., 1996; Feng et al., 1996)., UL https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-77-12-2905