1887

Abstract

It was previously reported that administration of cadmium (Cd) to CBA mice latently infected with herpes simplex virus (HSV) results in a high incidence of virus reactivation . In the present study, Cd-inducible reactivation was used to compare CBA with four other laboratory mouse strains. HSV reactivation, as measured by the recovery of infectious particles from latently infected trigeminal ganglia following Cd treatment, occurred predominantly in the CBA strain and was almost entirely absent from other strains tested. There was no correlation of strain-dependent Cd toxicity with the recovery of infectious virus. examination of Cd-treated ganglia from latently infected CBA and BALB/c mice revealed that viral antigens were expressed exclusively in CBA specimens, but that viral replicative transcripts were expressed in both strains, although more strongly in CBA than in BALB/c specimens. We conclude that Cd treatment had induced reactivation of HSV from both mouse strains, and that the reactivation process was completed in CBA but not in BALB/c mice.

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1996-11-01
2022-09-25
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References

  1. Arvidson B., Tjälve H. 1986; Distribution of 109Cd in the nervous system of rats after intravenous injection. Acta Neuropathologica 69:111–116
    [Google Scholar]
  2. Bloom D. C., Devi-Rao G. B., Hill J. M., Stevens J. G., Wagner E. K. 1994; Molecular analysis of herpes simplex virus type 1 during epinephrine-induced reactivation of latently infected rabbits in vivo. journal of Virology 68:1283–1292
    [Google Scholar]
  3. Deatly A. M., Spivack J. G., Lavi E., Fraser N. W. 1987; RNA from an immediate early region of the HSV-1 genome is present in the trigeminal ganglia of latently infected mice. Proceedings of the National Academy of Sciences, USA 84:3204–3208
    [Google Scholar]
  4. Fawl R. L., Roizman B. 1993; Induction of reactivation of herpes simplex virus in murine sensory ganglia in vivo by cadmium. Journal of Virology 67:7025–7031
    [Google Scholar]
  5. Fraser N. W., Spivack J. G., Wroblewska Z., Block T., Deshmane S. L., Valyi-Nagy T., Natarajan R., Gesser R. M. 1990; A review of the molecular mechanism of HSV-1 latency. Current Eye Research10 (Suppl.) 1–13
    [Google Scholar]
  6. Gesser R. M., Valyi-Nagy T., Altshuler S. M., Fraser N. W. 1994; Oral-oesophageal inoculation of mice with herpes simplex virus type 1 causes latent infection of the vagal sensory ganglia (nodose ganglia). Journal of General Virology 75:2379–2386
    [Google Scholar]
  7. Hata A., Tsunoo H., Nakajima H., Shintaku K., Kimura M. 1980; Acute cadmium intoxication in inbred strains of mice: a study on strain differences. Chemico-Biological Interactions 32:29
    [Google Scholar]
  8. Kastrukoff L. F., Lau A. S., Puterman M. L. 1986; Genetics of natural resistance to herpes simplex virus type 1 latent infection of the peripheral nervous system in mice. Journal of General Virology 67:613–621
    [Google Scholar]
  9. Laycock K. A., Lee S. F., Brady R. H., Pepose J. S. 1991; Characterization of a murine model of recurrent herpes simplex viral keratitis induced by ultraviolet B radiation. Investigative Ophthalmology Visual Science 32:2741–2746
    [Google Scholar]
  10. Liu J., Kershaw W. C., Liu Y. P., Klaassen C. D. 1992; Cadmium-induced hepatic endothelial cell injury in inbred strains of mice. Toxicology 75:51–62
    [Google Scholar]
  11. Lopez C. 1975; Genetics of natural resistance to herpesvirus infections in mice. Nature 258:152–153
    [Google Scholar]
  12. Maitani T., Suzuki K. T. 1986; Effect of cadmium on essential metal concentrations in testis, liver and kidney of five inbred strains of mice. Toxicology 42:121–130
    [Google Scholar]
  13. Nolan C. V., Shaikh Z. A. 1986; An evaluation of tissue metallo-thionein and genetic resistance to cadmium toxicity in mice. Toxicology and Applied Pharmacology 85:135–144
    [Google Scholar]
  14. Openshaw H., Puga A., Notkins A. L. 1979a; Herpes simplex virus infection in sensory ganglia: immune control, latency, and reactivation. Federation Proceedings 38:2660–2664
    [Google Scholar]
  15. Openshaw H., Shavrina Asher L. V., Wohlenberg C., Sekizawa T., Notkins A. L. 1979b; Acute and latent infection of sensory ganglia with herpes simplex virus: immune control and virus reactivation. Journal of General Virology 44:205–215
    [Google Scholar]
  16. Price R. W., Schmitz J. 1978; Reactivation of latent herpes simplex virus infection of the autonomic nervous system by postganglionic neurectomy. Infection and Immunity 19:523–532
    [Google Scholar]
  17. Quaife C., Durnam D., Mottet N. K. 1984; Cadmium hypersusceptibility in the C3H mouse liver: cell specificity and possible role of metallothionein. Toxicology and Applied Pharmacology 76:9–14
    [Google Scholar]
  18. Rock D., Fraser N. 1983; Detection of HSV-1 genome in central nervous system of latently infected mice. Nature 302:523–525
    [Google Scholar]
  19. Roizman B., Sears A. 1993; Herpes simplex viruses and their replication. In The Human Herpesviruses pp 11–68 Edited by Roizman B., Whitley R. J., Lopez C. New York: Raven Press;
    [Google Scholar]
  20. Sawtell N. M., Thompson R. L. 1992; Rapid in vivo reactivation of herpes simplex virus in latently infected murine ganglionic neurons after transient hyperthermia. Journal of Virology 66:2150–2156
    [Google Scholar]
  21. Shaikh Z. A., Jordan S. A., STewari P. C. 1993; Cadmium disposition and metallothionein induction in mice: strain-, sex-, age- and dose-dependent differences. Toxicology 80:51–70
    [Google Scholar]
  22. Tsunoo H., Nakajima H., Hata A., Kimura M. 1979; Genetic influence on induction of metallothionein and mortality from cadmium intoxication. Toxicology Letters 4:253
    [Google Scholar]
  23. Willey D. E., Trousdale M. D., Nesburn A. B. 1984; Reactivation of murine latent HSV infection by epinephrine iontophoresis. Investigative Ophthalmology& Visual Science 25:945–950
    [Google Scholar]
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