1887

Abstract

Introduction. Accurate maintenance of the translational reading frame by ribosomes is essential for the production of functional proteins and unsurprisingly, errors in frame maintenance have been estimated to occur at rates probably lower than 5 × 10 per codon (Kurland, 1992). However, an increasing number of examples have been documented where a purposeful shift in reading frame is programmed into the mRNA and serves an essential function (Gesteland , 1992; Atkins & Gesteland, 1995). Highly efficient ribosomal frameshifting is an example of such a programmed frameshift site. In response to certain signals in the mRNA, ribosomes are induced to move into the -1 reading frame (in a 5′ direction) at a specific point and continue translation in the new reading frame. The phenomenon was first described in 1985 as the way in which the Gag-Pol polyprotein of the retrovirus Rous sarcoma virus (RSV) is expressed from the overlapping and open reading frames (ORFs) (Jacks & Varmus, 1985) and to date, most examples of frameshifting come from virus systems.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-76-8-1885
1995-08-01
2019-11-19
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-76-8-1885
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error