1887

Abstract

The complete nucleotide sequence of the RNA genome of Jembrana disease virus (JDV), a lentivirus that causes an acute disease syndrome in Bali cattle (), is reported. In addition to the and genes and flanking long terminal repeats (LTRs) that characterize all retroviruses, a number of accessory genes represented by small multiply spliced ORFs in the central and 3′-terminal regions of the genome, including and that are typical of lentiviruses, were identified. The genome of JDV was 7732 bp in length, 750 bp smaller than the genome of bovine immunodeficiency virus (BIV) strain BIV127. A striking feature of the genome was the many deletions relative to BIV127, the largest of which were 471 bp from the gene and 157 bp from the U3 (promoter) region in the LTR. There were also several insertions of up to 33 bp in the JDV genome relative to BIV127 found in the gene and small ORFs that overlap . Other significant genomic differences between JDV and BIV127 included changes to -acting sequences throughout the genome such as promoter and enhancer sequences in the LTR, the -activation response region, splice sites and frameshift sequences; alterations to the precursor protein cleavage sites and thus the processed products; loss of the and ORFs; and amino acid changes in all coding regions. The significance of these changes is discussed in relation to the differences in pathogenicity between JDV and BIV.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-76-7-1637
1995-07-01
2021-10-25
Loading full text...

Full text loading...

/deliver/fulltext/jgv/76/7/JV0760071637.html?itemId=/content/journal/jgv/10.1099/0022-1317-76-7-1637&mimeType=html&fmt=ahah

References

  1. Battles J. K., Hu M. Y., Rasmussen L., Tobin G. J., Gonda M. A. 1992; Immunological characterization of the gag gene products of bovine immunodeficiency virus. Journal of Virology 66:6868–6877
    [Google Scholar]
  2. Beisel C. E., Edwards J. F., Dunn L. L., Rice N. R. 1993; Analysis of multiple mRNAs from pathogenic equine infectious anemia virus (EIAV) in an acutely infected horse reveals a novel protein, Ttm, derived from the carboxy terminus of the EIAV transmembrane protein. Journal of Virology 67:832–842
    [Google Scholar]
  3. Benveniste R. E., Morton W. R., Clark E. A., Tsai C. C., Ochs H. D., Ward J. M., Kuller L., Knott W. B., Hill R. W., Gale M. J., Thouless M. E. 1988; Inoculation of baboons and macaques with simian immunodeficiency virus/Mne, a primate lentivirus closely related to human immunodeficiency virus type 2. Journal of Virology 62:2091–2101
    [Google Scholar]
  4. Budiarso I. T., Rikihisa Y. 1992; Vascular lesions in lungs of Bali cattle with Jembrana disease. Veterinary Pathology 29:210–215
    [Google Scholar]
  5. Carpenter S., Miller L. D., Alexandersen S., Whetstone C. A., Van Der maaten M. J., Viuff B., Wannemuehler Y., Miller J. M., Roth J. A. 1992; Characterization of early pathogenic effects after experimental infection of calves with bovine immunodeficiency-like virus. Journal of Virology 66:1074–1083
    [Google Scholar]
  6. Carpenter S., Nadin-davis S. A., Wannemuehler Y., Roth J. A. 1993; Identification of transactivation-response sequences in the long terminal repeat of bovine immunodeficiency-like virus. Journal of Virology 61:4399–4403
    [Google Scholar]
  7. Chadwick B. J., Coelen R. J., Sammels L. M., Kertayadnya G., Wilcox G. E. 1995; Genomic sequence analysis identifies Jembrana disease virus as a new bovine lentivirus. Journal of General Virology 16:189–192
    [Google Scholar]
  8. Chamorro M., Parkin N., Varmus H. E. 1992; An RNA pseudoknot and an optimal heptameric shift site are required for highly efficient ribosomal frameshifting on a retroviral messenger RNA. Proceedings of the National Academy of Sciences, USA 89:713–717
    [Google Scholar]
  9. Chirmule N., Kalyanaraman V. S., Saxinger C., Wong-staal F. 1990; Localization of B-cell stimulatory activity of HIV-1 to the carboxy terminus of gp41. AIDS Research and Human Retroviruses 6:299–305
    [Google Scholar]
  10. Courgnard V., Laure F., Fultz P. N., Montagnier L., Brechot C., Sonigo P. 1992; Genetic differences accounting for evolution and pathogenicity of simian immunodeficiency virus from sooty mangabey monkey after cross-species transmission to a pig-tailed macaque. Journal of Virology 66:414–419
    [Google Scholar]
  11. Dharma D. M. N., Budiantono A., Campbell R. S. F., Ladds P. W. 1991; Studies on experimental Jembrana disease in Bali cattle. III. Pathology. Journal of Comparative Pathology 105:397–414
    [Google Scholar]
  12. Dollard S. C., Gummuluru S., Tsang S. L., Fultz P. N., Dewhurst S. 1994; Enhanced responsiveness to nuclear factor kappa B contributes to the unique phenotype of simian immunodeficiency virus variant SIVSMMPBjl4. Journal of Virology 68:7800–7809
    [Google Scholar]
  13. Elder J. H., Lerner D. L., Hasselkus-light C. S., Fontenot D. J., Hunter E., Luciw P. A., Montelaro R. C., Phillips T. R. 1992; Distinct subsets of retroviruses encode dUTPase. Journal of Virology 66:1791–1794
    [Google Scholar]
  14. Fultz P. N. 1991; Replication of an acutely lethal simian immunodeficiency virus activates and induces proliferation of lymphocytes. Journal of Virology 65:4902–4909
    [Google Scholar]
  15. Fultz P. N. 1994; SIVSMMPBjl4: an atypical lentivirus. Current Topics in Microbiology and Immunology 188:65–76
    [Google Scholar]
  16. Garvey K. J., Oberste M. S., Elser J. E., Braun M. J., Gonda M. A. 1990; Nucleotide sequence and genome organization of biologically active proviruses of the bovine immunodeficiency-like virus. Virology 175:391–409
    [Google Scholar]
  17. Gonda M. A. 1992; Bovine immunodeficiency virus. AIDS 6:759–776
    [Google Scholar]
  18. Johnston P. B., Dubay J. W., Hunter E. 1993; Truncations of the simian immunodeficiency virus transmembrane protein confer expanded virus host range by removing a block to virus entry into cells. Journal of Virology 61:3077–3086
    [Google Scholar]
  19. Jones K. A., Kadonaga J. T., Lucrw P. A., Than R. 1986; Activation of the AIDS retrovirus promoter by the cellular transcription factor, Sp 1. Science 232:755–759
    [Google Scholar]
  20. Kawakami T., Sherman L., Dahlberg J., Gazit A., Yaniv A., Tronick S. R., Aaronson S. A. 1987; Nucleotide analysis of equine infectious anemia virus proviral DNA. Virology 158:300–312
    [Google Scholar]
  21. Kertayadnya G., Wilcox G. E., Soeharsono S., Hartaningsih N., Coelen R. J., Cook R. D., Collins M. E., Brownlie J. 1993; Characteristics of a retrovirus associated with Jembrana disease in Bali cattle. Journal of General Virology 74:1765–1773
    [Google Scholar]
  22. Lairmore M. D., Poulson J. M., Adducci T. A., Demartini J. C. 1988; Lentivirus-induced lymphoproliferative disease. American Journal of Pathology 130:80–90
    [Google Scholar]
  23. Lenardo M. J., Kuang A., Gifford A., Baltimore D. 1988; nf-kb protein purification from bovine spleen: nucleotide stimulation and binding site specificity. Proceedings of the National Academy of Sciences, USA 85:8825–8829
    [Google Scholar]
  24. Lewis M. G., Zack P. M., Elkins W. R., Jahrling P. B. 1992; Infection of rhesus and cynomolgus macaques with a rapidly fatal SIV (SIVSMM/PBj) isolate from sooty mangabeys. AIDS Research and Human Retroviruses 8:1631–1639
    [Google Scholar]
  25. Liu Z., Sheridan D., Wood C. 1992; Identification and characterization of the bovine immunodeficiency-like virus tat gene. Journal of Virology 66:5137–5140
    [Google Scholar]
  26. Martarano L., Stephens R., Rice N., Derse D. 1994; Equine infectious anemia virus Irani-regulatory protein Rev controls viral mRNA stability, accumulation, and alternative splicing. Journal of Virology 68:3102–3111
    [Google Scholar]
  27. Mazarin V., Gourdou I., Querat G., Sauze N., Vigne R. 1988; Genetic structure and function of an early transcript of visna virus. Journal of Virology 62:4813–4818
    [Google Scholar]
  28. Mermod N., Williams T. J., Tuan R. 1988; Enhancer binding factors AP-4 and AP-1 act in concert to activate SV40 late transcription in vitro. Nature 332:557–561
    [Google Scholar]
  29. Nair M. P. N., Pottathil R., Heimer E. P., Schwartz S. A. 1988; Immunoregulatory activities of human immunodeficiency virus (HIV) proteins: effect of HIV recombinant and synthetic peptides on immunoglobulin synthesis and proliferative peptides on immunoglobulin synthesis and proliferative responses by normal lymphocytes. Proceedings of the National Academy of Sciences, USA 85:6498–6502
    [Google Scholar]
  30. Neuveut C., Vigne R., Clements J. E., Sire J. 1993; The visna transcriptional activator TAT: effects on the viral LTR and on cellular genes. Virology 197:236–244
    [Google Scholar]
  31. Nevins J. R. 1983; The pathway of eukaryotic mRNA formation. Annual Review of Biochemistry 52:441–446
    [Google Scholar]
  32. Novembre F. J., Johnson P. R., Lewis M. G., Anderson D. C., Klumpp S., Mcclure H. M., Hirsch V. M. 1993; Multiple viral determinants contribute to pathogenicity of the acutely lethal simian immunodeficiency virus SIVSMMPBj variant. Journal of Virology 67:2466–2474
    [Google Scholar]
  33. Oberste M. S., Williamson J. C., Greenwood J. D., Nagashima K., Copeland T. D., Gonda M. A. 1993; Characterization of bovine immunodeficiency virus rev cDNAs and identification and subcellular localization of the rev protein. Journal of Virology 67:6395–6405
    [Google Scholar]
  34. Purcell D. F. J., Martin M. A. 1993; Alternative splicing of human immunodeficiency virus type 1 mRNA modulates viral protein expression, replication, and infectivity. Journal of Virology 61:6365–6378
    [Google Scholar]
  35. Querat G., Audoly G., Sonigo P., Vigne R. 1990; Nucleotide sequence analysis of SA-OMVV, a visna-related ovine lentivirus: phylogenetic history of lentiviruses. Virology 175:434–447
    [Google Scholar]
  36. Saltarelli M., Querat G., Konings D. A. M., Vigne R., Clements J. E. 1990; Nucleotide sequence and transcriptional analysis of molecular clones of CAEV which generate infectious virus. Virology 179:347–364
    [Google Scholar]
  37. Sinicco A., Palestro G., Caramello P., Giacobbi D., Giuliani G., Sciandra M., Giannini P. 1990; Acute HIV infection: clinical and biologic study of 12 patients. Journal of Acquired Immune Deficiency Syndrome 3:260–265
    [Google Scholar]
  38. Soeharsono S., Hartaningsih N., Soetrisno M., Kertayadnya G., Wilcox G. E. 1990; Studies of experimental Jembrana disease in Bali cattle. I. Transmission and persistence of the infectious agent in ruminants and pigs, and resistance of recovered cattle to reinfection. Journal of Comparative Pathology 103:49–59
    [Google Scholar]
  39. Soesanto M., Soeharsono S., Budiantono A., Sulistyana K., Tenaya M., Wilcox G. E. 1990; Studies on experimental Jembrana disease in Bali cattle. II. Clinical signs and haematological changes. Journal of Comparative Pathology 103:61–71
    [Google Scholar]
  40. Suarez D. L., Van der maaten M. J., Wood C., Whetstone C. A. 1993; Isolation and characterization of new wild-type isolates of bovine lentivirus. Journal of Virology 61:5051–5055
    [Google Scholar]
  41. Threadgill D. S., Steagall W. K., Flaherty M. T., Fuller F. J., Perry S. T., Rushlow K. E., Le grice S. F. J., Payne S. L. 1993; Characterization of equine infectious anemia virus dUTPase: growth properties of a dUTPase-deficient mutant. Journal of Virology 61:2592–2600
    [Google Scholar]
  42. Tobin G. J., Sowder R. C. >II, Fabris D., Hu M. Y., Battles J. K., Fenselau C., Henderson L. E., Gonda M. A. 1994; Amino acid sequence analysis of the proteolytic cleavage products of the bovine immunodeficiency virus gag precursor polypeptide. Journal of Virology 68:7620–7627
    [Google Scholar]
  43. Tomonaga K., Shin Y.-S., Fukasawa M., Miyazawa T., Adachi A., Mikami T. 1993; Feline immunodeficiency virus gene expression: analysis of the RNA splicing pattern and the mono-cistronic rev mRNA. Journal of General Virology 74:2409–2417
    [Google Scholar]
  44. Vellutini C., Philippon V., Gambarelli D., Horschowski N., Nave K., Navarro J. M., Auphan M., Courcoul M., Filippi P. 1994; The maedi-visna virus tat protein induces multiorgan lymphoid hyperplasia in transgenic mice. Journal of Virology 68:4955–4962
    [Google Scholar]
  45. Viglianti G. A., Sharma P. L., Mullins J. I. 1990; Simian immunodeficiency virus displays complex patterns of RNA splicing. Journal of Virology 64:4207–4216
    [Google Scholar]
  46. Weiher H., Konig M., Gruss P. 1983; Multiple point mutations affecting the simian virus 40 enhancer. Science 219:626–631
    [Google Scholar]
  47. Westendorp M. O., Li-weber M., Frank R. W., Krammer P. H. 1983; Human immunodeficiency virus type 1 tat upregulates interleukin-2 secretion in activated T cells. Journal of Virology 68:4177–4185
    [Google Scholar]
  48. Westervelt P., Trowbridge D. B., Epstein L. G., Blumberg B. M., Li Y., Hahn B. H., Shaw G. M., Price R. W., Ratner L. 1992; Macrophage tropism determinants of human immunodeficiency virus type 1 in vivo . Journal of Virology 66:2577–2582
    [Google Scholar]
  49. Wilcox G. E., Kertayadnya G., Hartaningsih N., Dharma D. M. N., Soeharsono S., Robertson T. 1992; Evidence for a viral aetiology of Jembrana disease in Bali cattle. Veterinary Microbiology 33:367–374
    [Google Scholar]
  50. Yamamoto J. K., Sparger E., Ho E. W., Andersen P. R., O’connor T. P., Mandell C. P., Lowenstine L., Munn R., Pedersen N. C. 1988; Pathogenesis of experimentally induced feline immunodeficiency virus infection in cats. American Journal of Veterinary Research 49:1246–1258
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-76-7-1637
Loading
/content/journal/jgv/10.1099/0022-1317-76-7-1637
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error