1887

Abstract

Transient transfections of tissue culture cells with plasmids encoding the transactivating factors MHBs and HBx of hepatitis B virus result in transcriptional stimulation of multiple target genes. Our experiments show that the NF-κB-binding enhancer element of simian virus 40 (SV40) and the AP-1-binding enhancer element of the human metallothionein IIA gene mediate the transactivating function of MHBs and HBx. In contrast, the elements GT(IIC+I) and Sph(II+I) of the SV40 enhancer, that, as a common feature, require binding of transcription factor TEF-1 for activity, efficiently mediate transactivation only by HBx but not by MHBs. This finding suggests that at least one regulatory pathway exists that can only be activated by HBx but not by MHBs.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-76-4-1033
1995-04-01
2019-11-12
Loading full text...

Full text loading...

http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-76-4-1033
Loading

Most Cited This Month

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error