Recent H3N2 swine influenza virus with haemagglutinin and nucleoprotein genes similar to 1975 human strains Free

Abstract

Of the four pandemic strains of human influenza A virus observed this century, the 1977 virus strain was very similar in all genes to a 1950 isolate. Since mammalian influenza A viruses change annually by genetic drift, this reappearance could only be attributed at that time to conservation of the virus in a frozen state. We report here the isolation of swine influenza A viruses with haemagglutinin and nucleoprotein genes which are virtually identical to those of the human virus that circulated in 1975. We have also found serological evidence that this virus is circulating extensively in Quebec swine herds. We propose that human-like H3N2 influenza A strains may remain invariant for long periods in swine, which may serve as a reservoir for human pandemics.

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1995-03-01
2024-03-29
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References

  1. Bean W. J., Schell M., Katz J., Kawaoka Y., Naeve C., Gorman O. T., Webster R. G. 1992; Evolution of the H3 influenza virus hemagglutinin from human and nonhuman hosts. Journal of Virology 66:1129–1138
    [Google Scholar]
  2. Bikour M. H., Cornaglia E., Weber J. M., Elazhary Y. 1994; Antigenic characterization of an H3N2 swine influenza virus isolated from pigs with proliferative and necrotizing pneumonia in Quebec. Canadian Journal of Veterinary Research 58:287–290
    [Google Scholar]
  3. Castrucci M. R., Donatelli I., Sidoli L., Barigazzi G., Kawaoka Y., Webster R. G. 1993; Genetic reassortment between avian and human influenza A viruses in Italian pigs. Virology 193:503–506
    [Google Scholar]
  4. Castrucci M. R., Campitelli L., Ruggieri A., Barigazzi G., Sidoli L., Daniels R., Oxford J. S., Donatelli I. 1994; Antigenic and sequence analysis of H3 influenza virus haemag-glutinins from pigs in Italy. Journal of General Virology 75:371–379
    [Google Scholar]
  5. Chomczynski P., Sacchi N. 1987; Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol chloroform extraction. Analytical Biochemistry 162:156–159
    [Google Scholar]
  6. Devereux J., Haberli P., Smithies O. 1984; A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Research 12:387–395
    [Google Scholar]
  7. Elazhary M. A. S. Y., Dea S., Mittal K. R., Higgins R. 1985; Prevalence of antibodies to swine influenza virus, porcine adenovirus type 4 and Haemophilus pleuropneumoniae in Quebec pig farms with respiratory problems. Canadian Veterinary Journal 26:190–192
    [Google Scholar]
  8. Gammelin M., Mandler J., Scholtissek C. 1989; Two subtypes of nucleoproteins (NP) of influenza A viruses. Virology 170:71–80
    [Google Scholar]
  9. Girard C., Morin M., Elazhary Y. 1992; Experimentally induced porcine proliferative and necrotising penumonia with an influenza A virus. Veterinary Record 130:206–207
    [Google Scholar]
  10. Gorman O. T., Bean W. J., Kawaoka Y., Webster R. G. 1990; Evolution of the nucleoprotein gene of influenza A virus. Journal of Virology 64:1487–1497
    [Google Scholar]
  11. Gorman O. T., Bean W. J., Kawaoka Y., Donatelli I., Guo Y., Webster R. G. 1991; Evolution of influenza A virus nucleoprotein genes: Implications for the origins of HINI human and classical swine viruses. Journal of Virology 65:3704–3714
    [Google Scholar]
  12. Harkness J. W., Schild G. C., Lamont P. H., Brand C. M. 1972; Studies on relationships between human and porcine influenza. I. Serological evidence of infection in swine in Great Britain with an influenza A virus antigenically like human Hong Kong/68 virus. Bulletin of the World Health Organization 46:709–719
    [Google Scholar]
  13. Hinshaw V. S., Bean W. J., Webster R. G., Easterday B. C. 1978; The prevalence of influenza viruses in swine and the antigenic and genetic relatedness of influenza viruses from man and swine. Virology 84:51–62
    [Google Scholar]
  14. Kida H., Shortridge K. F., Webster R. G. 1988; Origin of the hemagglutinin gene of H3N2 influenza viruses from pigs in China. Virology 162:160–166
    [Google Scholar]
  15. KundiN W. D. 1970; Hong Kong A-2 influenza virus infection among swine during human epidemic in Taiwan. Nature 228:857
    [Google Scholar]
  16. Luoh S. M., McGregor M. W., Hinshaw V. S. 1992; Hemagglutinin mutations related to antigenic variation in HI swine influenza viruses. Journal of Virology 66:1066–1073
    [Google Scholar]
  17. Morin M., Girard C., Elazhary Y., Fajardo R., Drolet R., Lagace A. 1990; Severe proliferative and necrotizing pneumonia in pigs: A newly recognized disease. Canadian Veterinary Journal 31:837–839
    [Google Scholar]
  18. Naeve C. W., Hinshaw V. S., Webster R. G. 1984; Mutations in the hemagglutinin receptor-binding site can change the biological properties of an influenza virus. Journal of Virology 51:567–569
    [Google Scholar]
  19. Nakajima K., Desselberger U., Palese P. 1978; Recent human influenza A (H1N1) viruses are closely related genetically to strains isolated in 1950. Nature 274:334–339
    [Google Scholar]
  20. Nakajima K., Nakajima S., Shortridge K. F., Kendal A. P. 1982; Further genetic evidence for maintenance of early Hong Kong-like influenza A(H3N2) strains in swine until 1976. Virology 116:562–572
    [Google Scholar]
  21. Olsen C. W., McGregor M. W., Cooley A. J., Schantz B., Hotze B., Hinshaw V. S. 1993; Antigenic and genetic analysis of a recently isolated H1N1 swine influenza virus. American Journal of Veterinary Research 54:1630–1636
    [Google Scholar]
  22. Palmer D. F., Coleman M. T., Dowdle W. R., Schild G. C. 1975 Advanced laboratory techniques for the influenza diagnosis Atlanta: US Department of Health, Education and Welfare, Center for Disease Control;
    [Google Scholar]
  23. Raymond F. L., Caton A. J., Cox N. J., Kendal A. P., Brownlee G. G. 1986; The antigenicity and evolution of influenza HI haemagglutinin, from 1950–1957 and 1977–1983: two pathways from one gene. Virology 148:275–287
    [Google Scholar]
  24. Rocha E. P., Xu X., Hall H. E., Allen J. R., Regnery H. L., Cox N. J. 1993; Comparison of 10 influenza A (H1N1 and H3N2) haemagglutinin sequences obtained directly from clinical specimens to those of MDCK cell- and egg-grown viruses. Journal of General Virology 74:2513–2518
    [Google Scholar]
  25. Scholtissek C., von Hoyningen V., Rott R. 1978; Genetic relatedness between the new 1977 epidemic strains (H1N1) of influenza and human influenza strains isolated between 1947 and 1957 (H1N1). Virology 89:613–617
    [Google Scholar]
  26. Shortridge K. F., Webster R. G., Butterfield W. K., Campbell C. H. 1977; Persistence of Hong Kong influenza virus variants in pigs. Science 196:1454–1455
    [Google Scholar]
  27. Shortridge K. F., King A. P., Webster R. G. 1987; Monoclonal antibodies for characterizing H3N2 influenza viruses that persist in pigs in China. Journal of Infectious Diseases 155:577–581
    [Google Scholar]
  28. Shu L. L., Bean W. J., Webster R. G. 1993; Analysis of the evolution and variation of the human influenza A virus nucleoprotein gene from 1933 to 1990. Journal of Virology 67:2723–2729
    [Google Scholar]
  29. Van Dreumel A. A., Ditchfield W. J. 1968; An outbreak of swine influenza in Manitoba. Canadian Veterinary Journal 9:275–278
    [Google Scholar]
  30. Webster R. G., Bean W. J., Gorman O. T., Chambers T. M., Kawaoka Y. 1992; Evolution and ecology of influenza A viruses. Microbiological Reviews 56:152–179
    [Google Scholar]
  31. Wiley D. C., Wilson I. A., Skehel J. J. 1981; Structural identification of the antibody-binding sites of Hong Kong influenza haemagglutinin and their involvement in antigenic variation. Nature 289:373–378
    [Google Scholar]
  32. Yamada A., Nobusawa E., Cao M.-S., Imanishi J., Oyama S., Abe A., Katagiri S., Kim D. W., Nakajima K., Nakajima S. 1991; Epitope changes on the haemagglutinin molecule of recently isolated H1N1 influenza viruses. Journal of General Virology 72:97–102
    [Google Scholar]
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