%0 Journal Article %A Colas, Sandrine %A Bourge, Jean-François %A Wybier, Janine %A Chelbi-Alix, Mounira K. %A Paul, Pascale %A Emanoil-Ravier, Rodica %T Human foamy virus infection activates class I major histocompatibility complex antigen expression %D 1995 %J Journal of General Virology, %V 76 %N 3 %P 661-667 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-76-3-661 %I Microbiology Society, %X We examined the effect of human foamy virus (HFV) infection on the expression of human major histocompatibility complex molecules. Our data show that in vitro HFV infection of U373-MG glioblastoma cells results in increased expression of class I human leukocyte antigen (HLA) and transcripts. Transient transfection assays of plasmids containing the reporter gene chloramphenicol acetyl transferase driven by different 5′ deletions of the HLA-A11 class I promoter allowed identification of cis-acting elements involved in this regulation. HFV infection has two opposite effects on the HLA class I promoter: transactivation of the HLA-A11 promoter through a positive regulatory element located in the -525 to -335 region upstream of exon 1 and down-regulation of transcriptional activity driven by the -335 to -205 class I promoter region. Additional experimental data indicate that the effect of HFV on HLA class I expression is not mediated by the interferon pathway. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-76-3-661