A cellular form of prion protein (PrPC) exists in many non-neuronal tissues of sheep

References

1. Alpers M. 1987; Epidemiology and clinical aspects of kuru. In Prion –Novel Infectious Pathogens causing Scrapie and Creutzfeldt–Jakob Disease pp 451–465 Edited by Prusiner S. B., McKinley M. P. Orlando: Academic Press;
   [Google Scholar]
2. Bendheim P. E., Brown H. R., Rudelli R. D., Scala L. J., Goller N. L., Wen G. Y., Kascsak R. J., Cashman N. R., Bolton D. C. 1992; Nearly ubiquitous tissue distribution of the scrapie agent precursor protein. Neurology 42:149–156
   [Google Scholar]
3. Bolton D. C., McKinley M. P., Prusiner S. B. 1982; Identification of a protein that purifies with the scrapie prion. Science 218:1309–1311
   [Google Scholar]
4. Büeler H., Aguzzi A., Sailer A., Greiner R.-A., Autenried P., Aguet M., Weissmann C. 1993; Mice devoid of PrP are resistant to scrapie. Cell 73:1339–1347
   [Google Scholar]
5. Caughey B., Raymond G. J. 1991; The scrapie-associated form of PrP is made from a cell surface precursor that is both protease-and phospholipase-sensitive. Journal of Biological Chemistry 266:18217–18223
   [Google Scholar]
6. Caughey B., Race R. E., Chesebro B. 1988; Detection of prion protein mRNA in normal and scrapie-infected tissues and cell lines. Journal of General Virology 69:711–716
   [Google Scholar]
7. Chomczynski P., Sacchi N. 1987; Single-step method of RNA isolation by acid guanidinium thiocyanate–phenol–chloroform extraction. Analytical Biochemistry 162:156–159
   [Google Scholar]
8. Collinge J., Whittington M. A., Sidle K. C. L., Smith C. J., Palmer M. S., Clarke A. R., Jefferys J. G. R. 1994; Prion protein is necessary for normal synaptic function. Nature 370:295–297
   [Google Scholar]
9. Danner K. 1993; BSE–a risk for man through pharmaceutical products? Position and politics of the German pharmaceutical industry. In Transmissible Spongiform Encephalopathies – Impact on Animal and Human Health pp 199–205 edited by Brown. F. Basel: Karger.;
   [Google Scholar]
10. Hadlow W. J., Race R. E., Kennedy R. C., & Eklund C. M. 1979; Natural infection of sheep with scrapie virus. In Slow Transmissible Diseases of the Nervous System vol 2 pp 3–12 Edited by Prusiner S. B., Hadlow W. J. New York: Academic Press;
    [Google Scholar]
11. Hadlow W. J., Kennedy R. C., Race R. E. 1982; Natural infection of Suffolk sheep with scrapie virus. Journal of Infectious Diseases 146:657–664
    [Google Scholar]
12. Hartsough G. R., Burger D. 1965; Encephalopathy of mink. I. Epizootiologic and clinical observations. Journal of Infectious Diseases 115:387–392
    [Google Scholar]
13. Ikeda T., Onodera A., Horiuchi M., Ishiguro N., Muramatsu Y., Shinagawa M. 1995; Amino acid polymorphisms of PrP with reference to RFLP-haplotypes of the PrP gene and onset of scrapie in Suffolk and Corriedale sheep in Japan. Journal of General Virology 76:2577–2581
    [Google Scholar]
14. Ikegami Y., Ito M., Isomura H., Momotani E., Sasaki K., Muramatsu Y., Ishiguro N., Shinagawa M. 1991; Preclinical and clinical diagnosis of scrapie by detection of PrP protein in tissues of sheep. Veterinary Record 128:271–275
    [Google Scholar]
15. Rubenstein R., Merz P. A., Kascsak R. J., Carp R. I., Scalici C. L., Fama C. L., Wisniewski H. M. 1987; Detection of scrapie-associated fibrils (SAP) and SAF proteins from scrapie-affected sheep. Journal of Infectious Diseases 156:36–42
    [Google Scholar]
16. Sambrook J., Fritsch E. F., Maniatis T. 1989 Molecular Cloning: A Laboratory Manual 2nd edn New York: Cold Spring Harbor Laboratory;
    [Google Scholar]
17. Tokunaga K., Taniguchi H., Yoda K., Shimizu M., Sakiyama S. 1986; Nucleotide sequence of a full-length cDNA for mouse cytoskeletal β-actin mRNA. Nucleic Acids Research 16:2829
    [Google Scholar]
18. Westaway D., Zuliani V., Cooper C. M., Costa M. D., Neuman S., Jenny A. L., Detwiler L., Prusiner S. B. 1994; Homozygosity for prion protein alleles encoding glutamine-171 renders sheep susceptible to natural scrapie. Genes & Development 8:959–969
    [Google Scholar]
19. Wilesmith J. W., Wells G. A. H., Cranwell M. P., Ryan J. B. M. 1988; Bovine spongiform encephalopathy: epidemiological studies. Veterinary Record 123:638–644
    [Google Scholar]