1887

Abstract

Epstein-Barr virus (EBV) CD8 cytotoxic T lymphocyte (CTL) epitopes are currently being considered for inclusion into subunit vaccines. Here we describe the characterization of live new CTL epitopes within EBV nuclear antigen 3 (EBNA3), confirming EBNA3 as a major target for CTL recognition.

Loading

Article metrics loading...

/content/journal/jgv/10.1099/0022-1317-75-9-2489
1994-09-01
2022-01-24
Loading full text...

Full text loading...

/deliver/fulltext/jgv/75/9/JV0750092489.html?itemId=/content/journal/jgv/10.1099/0022-1317-75-9-2489&mimeType=html&fmt=ahah

References

  1. Andersson M. L., Siam N. J., Klein G., Pleogh H. L., Masucci M. G. 1991; Aberrant expression of HLA class I antigens in Burkitt lymphoma cells. International Journal of Cancer 47:544–550
    [Google Scholar]
  2. Apolloni A., Moss D., Stumm R., Burrows S., Suhrbier A., Misko I., Schmidt C., Sculley T. 1992; Sequence variation of cytotoxic T ceil epitopes in different isolates of Epstein-Barr virus. European Journal of Immunology 22:183–189
    [Google Scholar]
  3. Bodmer J. G., Marsh S. G. E., Albert E. D., Bodmer W. F., Dupont B., Erlich H. A., Mach B., Mayr W. R., Parham P., Sasazuki T., Schreuder G. M. TH., Strominger J. L., Svejgaard A., Terasaki P. I. 1991; Nomenclature for factors of the HLA system, 1991. Vox sanguinis 63:142–157
    [Google Scholar]
  4. Brooks J. M., Murray R. J., Thomas W. A., Kurii.LA M. G., Rickinson A. B. 1993; Different HLA-B27 subtypes present the same immunodominant Epstein-Barr virus peptide. Journal of Experimental Medicine 178:879–887
    [Google Scholar]
  5. Burrows S. R., Suhrbier A., Khanna R., Moss D. J. 1992; Rapid visual assay of cytotoxic T-cell specificity utilizing synthetic peptide induced T-cell-T-cell killing. Immunology 76:174–175
    [Google Scholar]
  6. Culmann B., Gomard E., Kieny M., Guy B., Dreyfus F., Saimot A., Sereni D., Sicard D., Levy J. 1991; Six epitopes reacting with human cytotoxic CD8+T cells in the central region of the HIV- 1 NEF protein. Journal of Immunology 146:1560–1565
    [Google Scholar]
  7. Dhar V., Schildkraut C. L. 1991; Role of EBNA-1 in arresting replication forks at the Epstein-Barr virus oriP family of tandem repeats. Molecular and Cellular Biology 11:6268–6278
    [Google Scholar]
  8. Falk K., Rotzschke O., Stevanovic S., Jung G., Rammensee H. 1991; Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC molecules. Nature; London: 351290–295
    [Google Scholar]
  9. Gammon G., Geysen H. M., Apple R. J., Pickett E., Palmer M., Ametani A., Sercarz E. E. 1991; T cell determinant structure: cores and determinant envelopes in three mouse major histocompatibility complex haplotypes. Journal of Experimental Medicine 173:609–617
    [Google Scholar]
  10. Gratama J. W., Oosterveer M. A. P., Klein G., Ernberg I. 1990; EBNA size polymorphism can be used to trace Epstein-Barr virus spread within families. Journal of Virology 64:4703–4708
    [Google Scholar]
  11. Heinig J., Radka S. F., Kompf J., Fonatsch C. 1985; Monosomy 6 in a human lymphoma line induced by selection with a monoclonal antibody. Immunobiology 169:455–160
    [Google Scholar]
  12. Hill A. V. S., Elvin J., Willis A. C., Aidoo M., Allsopp C. E. M., Gotch F. M., Minggao X., Takiguchi M., Greenwood B. M., Townsend A. R. M., Mcmichael A. J., Whittle H. C. 1992; Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature; London: 360434–439
    [Google Scholar]
  13. Khanna R., Burrows S. R., Kurilla M. G., Jacob C. A., Misko I. S., Sculley T. B., Kieff E., Moss D. J. 1992; Localization of Epstein-Barr virus cytotoxic T cell epitopes using recombinant vaccinia: implications for vaccine development. Journal of Experimental Medicine 176:169–176
    [Google Scholar]
  14. Lopez De Castro J. A. 1989; HLA-B27 and HLA-A2 subtypes: structure, evolution and function. Immunology Today 10:239–246
    [Google Scholar]
  15. Misko I. S., Pope J. H., Huetter R., Soszynski T. D., Kane R. G. 1984; HLA-DR-antigen-associated restriction of EBV-specific cytotoxic T-cell colonies. International Journal of Cancer 33:239–243
    [Google Scholar]
  16. Moss D. J., Suhrbier A. 1993; Epstein-Barr virus vaccines - prospects and limitations. Today’s Life Science 5:30–34
    [Google Scholar]
  17. Moss D. J., Burrows S. R., Khanna R., Misko I. S., Sculley T. B. 1992; Immune surveillance against Epstein-Barr virus. Seminars in Immunology 4:97–104
    [Google Scholar]
  18. Murray R. J., Kurrilla M. G., Brooks J. M., Thomas W. A., Rowe M., Kief E., Rickinson A. B. 1992; Identification of target antigens for the human cytotoxic T cell response to Epstein- Barr virus (EBV): implications for the immune control of EBV- positive malignancies. Journal of Experimental Medicine 176:157–168
    [Google Scholar]
  19. Rosenberg S. A., Grimm E. A., McGrogan M., Doyle M., Kawasaki E., Koths K., Mark D. F. 1984; Biological activity of recombinant human interleukin-2 produced in Escherichia coli . Science 223:1412–1414
    [Google Scholar]
  20. Sample J., Young L., Martin B., Chatman T., Kieff E., Rickinson A., Kieff E. 1990; Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes. Journal of Virology 64:4084–4092
    [Google Scholar]
  21. Sinigaglia F., Guttinger M., Kilgus J., Doran D. M., Matile H., Etlinger H., Trzeciak A., Gillessen D., Pink J. R. L. 1988; A malaria T-cell epitope recognized in association with most mouse and human MHC class II molecules. Nature; London: 336778–780
    [Google Scholar]
  22. Suhrbier A., Schmidt C., Fernan A. 1993; Prediction of an HLA B8-restricted influenza epitope by motif. Immunology 79:171–173
    [Google Scholar]
  23. Szekely L., Selivanova G., Magnusson K. P., Klein G., Wiman K. G. 1993; EBNA-5, an Epstein Barr virus-encoded nuclear antigen, binds to the retinoblastoma and p53 proteins. Proceedings of the National Academy of Sciences U.S.A.: 905455–5459
    [Google Scholar]
  24. Valerio R. M., Benstead M., Bray A. M., Campbell R. A., Maeji N. J. 1991; Synthesis of peptide analogues using the multipin peptide synthesis method. Analytical Biochemistry 197:168–177
    [Google Scholar]
  25. Wang A., Lu S. D., Mark D. F. 1984; Site-specific mutagenesis of the human interleukin-2 gene: structure-function analysis of the cysteine residues. Science 224:1431–1433
    [Google Scholar]
  26. Wang D., Liebowitz D., Kieff E. 1985; An EBV membrane protein expressed in immortalized lymphocytes transforms established rodent cells. Cell 43:831–840
    [Google Scholar]
  27. Widmann C., Maryanski J. L., Romero P., Corradin G. 1991; Differential stability of antigenic MHC class I-restricted synthetic peptides. Journal of Immunology 147:3745–3751
    [Google Scholar]
  28. Zhang Q., Gavioli R., Klein G., Masucci M. G. 1993; An HLA-A11-specific motif in nonamer peptides derived from viral and cellular proteins. Proceedings of the National Academy of Sciences U.S.A.: 902217–2221
    [Google Scholar]
http://instance.metastore.ingenta.com/content/journal/jgv/10.1099/0022-1317-75-9-2489
Loading
/content/journal/jgv/10.1099/0022-1317-75-9-2489
Loading

Data & Media loading...

Most cited this month Most Cited RSS feed

This is a required field
Please enter a valid email address
Approval was a Success
Invalid data
An Error Occurred
Approval was partially successful, following selected items could not be processed due to error