1887

Abstract

Recognition of a host cell receptor by a virus is the first and perhaps the most crucial step in initiating the disease process. This study was undertaken to identify the cellular receptor(s) for bovine herpesvirus 1 (BHV-1). Previously, we reported the development and characterization of bovine anti-idiotypic antibodies (anti-ids) that induce neutralizing antibodies to BHV-1. These anti-ids inhibit BHV-1 penetration of permissive cells. We have used these anti-ids, which mimic an epitope on the virus glycoprotein IV (gIV), and gradient-purified virus in immunoprecipitation (IP) as well as photoaffinity labelling (PAL) assays. In the IP assays, both bovine anti-ids and BHV-1 virions coupled to Sepharose precipitated a 60K protein from I-labelled BHV-1 permissive cell membrane extracts. Normal bovine IgG or an irrelevant virus, transmissible gastroenteritis virus (TGEV), used as negative controls failed to precipitate this protein. Similarly, in the PAL assays, the 60K cell surface protein was identified on cells permissive for BHV-1 infection, but not on non-permissive cells when I-labelled ligands, the anti-ids or BHV-1 were used as probes. The iodinated ligands failed to identify the 60K protein if they had been pretreated with the antibody 1. Pretreatment of the iodinated ligands with an isotype-matched control antibody had no effect on the identification of the 60K protein present on cells permissive for BHV-1 infection. The negative controls, i.e. normal bovine IgG and TGEV, failed to identify this 60K protein on permissive or non-permissive cells. These results suggest that the 60K protein is a cellular receptor recognized by BHV-1 during the infection process.

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1994-09-01
2021-10-22
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References

  1. Breau W. C., Atwood W. J., Norkin L. C. 1992; Class I major histocompatibility proteins are an essential component of the simian virus 40 receptor. Journal of Virology 66:2037–2045
    [Google Scholar]
  2. Campadelli-Fiume G., Arsenakis M., Farabegoli F., Roizman B. 1988; Entry of herpes simplex virus 1 in BJ cells that constitutively express viral glycoprotein D is by endocytosis and results in degradation of the virus. Journal of Virology 62:159–167
    [Google Scholar]
  3. Campadelli-Fiume G. A., Qi S., Avitabile E., Foa-Tomasi L., Brandimarti R., Roizman B. 1990; Glycoprotein D of herpes simplex virus encodes a domain which precludes penetration of cells expressing the glycoprotein by superinfecting herpes simplex virus. Journal of Virology 64:6070–6079
    [Google Scholar]
  4. Chase C. C. L., Letchworth G. J. 1994; Bovine herpesvirus 1 gIV-expressing cells resist virus penetration. Journal of General Virology 15:177–181
    [Google Scholar]
  5. Chase C. C. L., Carter-Allen K., Lohff C., Letchworth G. J. 1990; Bovine cells expressing bovine herpesvirus 1 (BHV-1) glycoprotein IV resist infection by BHV-1, herpes simplex virus, and pseudorabies virus. Journal of Virology 64:4866–4872
    [Google Scholar]
  6. Clark C. G., Armstrong G. D. 1990; Lymphocyte receptors for pertussis toxin. Infection and Immunity 58:3840–3846
    [Google Scholar]
  7. Co M. S., Gaulton G. N., Fields B. N., Green M. I. 1985; Isolation and biochemical characterization of the mammalian reovirus type 3 cell-surface receptor. Proceedings of National Academy of Sciences U.S.A: 821494–1498
    [Google Scholar]
  8. Coligan J. E., Kruisbeek A. M., Margulies D. H., Shevach E. M., Strober W. 1991 editor Isolation and analysis of proteins. In Current Protocols in Immunology, 1 pp 8.0.1–8.12.9 John Wiley & Sons, Inc., NY; U.S.A.:
    [Google Scholar]
  9. Crowell R. L. 1987; Cellular receptors in virus infections. American Society for Microbiology News 53:422–425
    [Google Scholar]
  10. Dalgleish A. G., Beverly P. C. L., Clapham P. R., Crawford D. H., Greaves M. F., Weiss R. A. 1984; The CD4 (T4) antigen is an essential component of the receptor for the AIDS retrovirus. Nature; London: 312763–767
    [Google Scholar]
  11. Delmas B., Gelfi J., L’Haridon R., Vogel L. K., Sjostrom H., Noren O., Laude H. 1992; Aminopeptidase N is a major receptor for the enteropathogenic coronavirus TGEV. Nature; London: 357417–420
    [Google Scholar]
  12. Fehler F., Herrmann J. M., Saalmoller A., Mettenletter T. C., Keil G. M. 1992; Glycoprotein IV of bovine herpesvirus 1- expressing cell line complements and rescues a conditionally lethal viral mutant. Journal of Virology 66:831–839
    [Google Scholar]
  13. Fitzpatrick D. R., Redmond M. J., Attah-Poku S. K., Van Drunen Littel-Van Den Hurk S., Babiuk L. A., Zamb T. J. 1990; Mapping of 10 epitopes of bovine herpesvirus 1 gl and gill. Virology 176:145–157
    [Google Scholar]
  14. Hariharan K., Hariharan M. J., Zamb T. J., Krueger R. J., Srikumaran S. 1991; Bovine monoclonal anti-idiotypes induce antibodies specific for a synthetic peptide bearing a neutralizing epitope of bovine herpesvirus 1 glycoprotein gl (gB). Journal of Immunology 146:3489–3495
    [Google Scholar]
  15. Highlander S. L., Cai W., Pearson S., Levine M., Glorioso J. C. 1988; Monoclonal antibodies define a domain on herpes simplex virus glycoprotein B involved in virus penetration. Journal of Virology 62:1881–1888
    [Google Scholar]
  16. Hughes G., Babiuk L. A., Van Drunen Littel-Van Den Hurk S. 1988; Functional and topographical analyses of epitopes on bovine herpesvirus type 1 glycoprotein IV. Archives of Virology 103:47–60
    [Google Scholar]
  17. Johnson D. C., Ligas M. W. 1988; Herpes simplex viruses lacking glycoprotein D are unable to inhibit virus penetration: quantitative evidence for virus-specific cell surface receptors. Journal of Virology 62:4605–4612
    [Google Scholar]
  18. Johnson D. C., Wittels M., Spear P. G. 1984; Binding to cells of virosomes containing herpes simplex virus type 1 glycoproteins and evidence for fusion. Journal of Virology 52:238–247
    [Google Scholar]
  19. Klatzmann D., Champagne E., Chamaret S., Gruest J., Guetard D., Hercend T., Gluckman J. C., Montagnier L. 1984; T lymphocyte T4 molecule behaves as the receptor for human retrovirus LAV. Nature; London: 312767–768
    [Google Scholar]
  20. Lentz T. L. 1990; The recognition event between virus and host cell receptor: a target for antiviral agents. Journal of General Virology 71:751–766
    [Google Scholar]
  21. Liang X., Babiuk L. A., Van Drunen Littel-Van Den Hurk S., Fitzpatrick D. R., Zamb T. J. 1991; Bovine herpesvirus 1 attachment to permissive cells is mediated by its major glycoproteins gI, gIII and gIV. Journal of Virology 65:1124–1132
    [Google Scholar]
  22. Liang X., Babiuk L. A., Zamb T. J. 1992; An in vitro study of a glycoprotein gill-negative bovine herpesvirus 1 (BHV-1) mutant expressing beta-galactosidase: evaluation of the role of gill in virus infectivity and its use as a vector for mucosal immunization. Virology 189:629–639
    [Google Scholar]
  23. Markwell M. A. K., Svennerholm L., Paulson J. C. 1981; Specific gangliosides function as host cell receptors for Sendai virus. Proceedings of the National Academy of Sciences U.S.A: 785406–5410
    [Google Scholar]
  24. Marriott S. J., Roeder D. J., Consigli R. A. 1987; Antiidiotypic antibodies to a polyomavirus monoclonal antibody recognize cell surface components of mouse kidney cells and prevent polyomavirus infection. Journal of Virology 61:2747–2753
    [Google Scholar]
  25. Misra V., Bluementhal R. M., Babiuk L. A. 1981; Proteins specified by bovine herpesvirus type 1 (infectious bovine rhino- tracheitis virus). Journal of Virology 40:367–378
    [Google Scholar]
  26. Nettleton P. F., Sharp J. M. 1980; Infectious bovine rhino- tracheitis virus excretion after vaccination. Veterinary Record 10 7:379
    [Google Scholar]
  27. Noseworthy J. H., Fields B. N., Diohter M. A., Sobotka C., Pizer E., Perry L. L., Nepom J. T., Greene M. I. 1983; Cell receptors for the mammalian reovirus: I. Syngeneic monoclonal anti-idiotypic antibody identifies a cell surface receptor for reovirus. Journal of Immunology 131:2533–2538
    [Google Scholar]
  28. Okazaki K., Matsuzaki T., Sugahara Y., Okada J., Hasebe M., Iwamura Y., Ohnishi M., Kanno T., Shimizu M., Honda E., Kono Y. 1991; BHV-1 adsorption is mediated by the interaction of glycoprotein gIII with heparin-like moiety on the cell surface. Virology 181:666–670
    [Google Scholar]
  29. Pastoret P. P., Babiuk L. A., Misra V., Griebel P. 1980; Reactivation of temperature-sensitive and non-temperature sensitive infectious bovine rhinotracheitis virus with dexamethasone. Infection and Immunity 29:483–488
    [Google Scholar]
  30. Roizman B., Sears A. E. 1990; Herpes simplex viruses and their replication. In Virology,, 2nd edn.. pp 1795–1841 Fields B. N., Knipe D. M. Edited by New York: Raven Press;
    [Google Scholar]
  31. Rouse B. T., Babiuk L. A. 1978; Mechanisms of recovery from herpesvirus infections. A review. Canadian Journal of Comparative Medicine 42:414–427
    [Google Scholar]
  32. Srikumaran S., Onisk D. V., Borca M. V., Nataraj C., Zamb T. J. 1990; Anti-idiotypic antibodies induce neutralizing antibodies to bovine herpesvirus 1. Immunology 70:284–289
    [Google Scholar]
  33. Wang K. S., Schmaljohn A. L., Kuhn R. J., Strauss J. H. 1991; Anti-idiotypic antibodies as probes for the Sindbis virus receptor. Virology 181:694–702
    [Google Scholar]
  34. Ward G. M. 1984; Labeling of cell membrane proteins. In Membranes, Detergents and Receptor Solubilization, pp 109–118 Venter J. C., Harrison L. C. Edited by New York: A. R. Liss;
    [Google Scholar]
  35. Weis W., Brown J. H., Cusack S., Paulson J. C., Skehel J. J., Wiley D. C. 1988; Structure of the influenza virus haemagglutinin complexed with its receptor sialic acid. Nature; London: 333426–431
    [Google Scholar]
  36. Wohlgemuth K., Herrich J. B. 1987; Bovine respiratory disease: an overview of costs, causes and control. Norden News 62:32–36
    [Google Scholar]
  37. Xue W., Minocha H. C. 1993; Identification of the cell surface receptor for bovine viral diarrhoea virus by using anti-idiotypic antibodies. Journal of General Virology 74:73–79
    [Google Scholar]
  38. Yates W. D. G. 1982; A review of infectious bovine rhinotracheitis, shipping fever pneumonia and viral-bacterial synergism in respiratory diseases of cattle. Canadian Journal of Comparative Medicine 46:225–263
    [Google Scholar]
  39. Yates W. D. G., Babiuk L. A., Jerico K. W. F. 1983; Viral- bacterial pneumonia in calves: duration of the interaction between bovine herpesvirus 1 and Pasteurella haemolytica. Canadian Journal of Comparative Medicine 47:257–264
    [Google Scholar]
  40. Yeager C. L., Ashmun R. A., Williams R. K., Cardellichio C. B., Shapiro L. H., Look A. T., Holmes K. V. 1992; Human aminopeptidase N is a receptor for human coronavirus TGEV. Nature; London: 357420–422
    [Google Scholar]
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