%0 Journal Article %A Willcocks, M. M. %A Brown, T. D. K. %A Madeley, C. R. %A Carter, M. J. %T The complete sequence of a human astrovirus %D 1994 %J Journal of General Virology, %V 75 %N 7 %P 1785-1788 %@ 1465-2099 %R https://doi.org/10.1099/0022-1317-75-7-1785 %I Microbiology Society, %X We have determined the complete genomic sequence of human astrovirus serotype 1 isolated in Newcastle upon Tyne. The genome is 6813 nucleotides long and contains three sequential open reading frames (ORFs). The two closest to the 5′ end are linked by a ribosomal frameshifting motif and contain sequence motifs indicative of non-structural virus proteins: serine protease and RNA-dependent RNA polymerase. A nuclear addressing sequence is also located here. The 3′ ORF encodes the virion structural polypeptides as a polyprotein precursor. This genomic organization resembles that of the plant virus family Luteoviridae. Nucleotide sequence data described in this paper appear in the EMBL database under accession no. Z25771. %U https://www.microbiologyresearch.org/content/journal/jgv/10.1099/0022-1317-75-7-1785